Cleome rutidosperma (White Mouzanmbé) : medicinal properties in alcoholic extraction

Cleome rutidosperma (White Mouzanmbé, Crawling Mouzanmbé, White Acaya, Little White Mouzambé, Crawling Mouzambé, Little White Acaya, Mouzanmbé blan, Ti Mouzanmbé ranpan, Ti kaya blan, Petit Mouzambé Blanc, Mouzambé rampant, petit Acaya blanc) — family Capparacées.

Scientific synonyms : Cleome ciliata Schumach. & Thonn., C guineensis-Hook I, C thyrisiflora-De Wild & TD, Sieruela rutidosperma –(DC.) Roalson & J. C. Hall.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 44 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Root.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mondal S (2009)

     Excerpt In the present study, the ethanolic extract of the roots of Cleome rutidosperma was tested for hypoglycaemic activity in normoglycaemic & alloxan induced hyperglycaemic rats at doses levels of 200 & 400 mg/kg p.o respectively. The study revealed that the root extract of CR caused significant reduction in the blood glucose level in both normoglycaemic & alloxan induced diabetic rats at the tested dose levels in a dose dependant manner.

   • According to Okoro IO (2014)

     Excerpt The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leaves & Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity & hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. The aqueous extract of both plants at different doses (125mg/Kg, 250mg/Kg & 500mg/Kg) administered orally to the diabetic rats for 28 days, produced significant (p < 0.05) decrease in the level of blood glucose, feed & water intake as well as serum cholesterol, triacylglycerols, low density lipoprotein (LDL), creatinine, urea, bilirubin & activity of liver marker enzymes such as AST, ALT, ALP & TBARS in liver and kidney.

   • According to Oridupa OA (2017)

     Excerpt The hypoglycaemic & antihyperglycaemic effects of methanol extract of leaves of Cleome rutidosperma (Cr) DC (Family: Capparidaceae) was investigated in Wistar rats. Fasting blood glucose levels (FBGL) were determined & alloxan-treated rats with BGL >200 mg/dl 48 h post-induction were considered diabetic.

   • According to Okoro I (2014)

     Excerpt the present study aimed to investigate the acute antihyperglycemic effects of four different solvent extracts (Petroleum ether, acetone, absolute ethanol & water) of two plants: Cleome rutidosperma (leaves) & Senecio biafrae (root) in STZ-induced diabetic mice & their in vitro antioxidant activities as well as their phytoconstituents. All extracts as well as the standard drug, glibenclamide (at 600 μg/kg body weight) significantly lowered blood glucose level (p<0.05) of the diabetic mice by 28.784±15.46-40.866±15.61% for CR & 10.652±6.36-19.858±7.65% for Senecio biafrae within 6 hrs of extracts administration.

   • According to Khuntia A (2022)

     Excerpt By centralizing medical data provided by the scientific literature, we offer in the present work a comprehensive perspective on a wide range of bioactive compounds identified from diverse Cleome species, emphasizing the correlation of natural active substances with potential pharmacological activities that can contribute to the improvement of therapeutic management for a range of pathologies. The potential biological actions & pharmacological effects, such as analgesic, anti-inflammatory, antipyretic, anti-diabetic, antidepressant, antibacterial, anti-arthritic, anticancer, & hepatoprotective are closely related to the active substances contained in various parts of the plants.

2. 2

   Pain: hyperalgesia, fever

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bose A (2007)

     Excerpt Oral administration of the ethanolic extract (200 a&400 mg/kg, p.o) & its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma produced significant analgesic activity in acetic acid-induced writhing & tail immersion tests, anti-inflammatory effect against carrageenin induced inflammation & adjuvant induced polyarthritis & antipyretic activity against yeast-induced pyrexia.

   • According to Khuntia A (2022)

     Excerpt The potential biological actions & pharmacological effects, such as analgesic, anti-inflammatory, antipyretic, anti-diabetic, antidepressant, antibacterial, anti-arthritic, anticancer, & hepatoprotective are closely related to the active substances contained in various parts of the plants. By centralizing medical data provided by the scientific literature, we offer in the present work a comprehensive perspective on a wide range of bioactive compounds identified from diverse Cleome species, emphasizing the correlation of natural active substances with potential pharmacological activities that can contribute to the improvement of therapeutic management for a range of pathologies.

   • According to Mondal (2009)

     Excerpt Mondal et al, Analgesic, anti-inflammatory & antipyretic studies of Cleome rutidosperma DC.

   • According to Ansari P (2016)

     Excerpt rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, & anthelmintic activities. Methods: Thermal method (hot plate test & tail flick test) was induced to judge the anti-inflammatory effect & couple of chemical method also used (formalin induced licking test; writhing test carried by acetic acid) to evaluate analgesic effect.

   • According to BOSE A (2004)

     Excerpt BOSE A et al, Analgesic & locomotor activity of extracts of Cleome rutidosperma DC, Indian j of Pharmaceut Sci, 66 (6):795-7, 2004,.

3. 3

   Fungal infection: Aspergillus niger, Penicillium notatum, Candida albicans, Helminthosporium solani

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Morah F (2018)

     Excerpt The oil exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus faecalis, Candida albicans & Aspergillus niger. The aim of this study is to determine the chemical constituents, anthelmintic & antimicrobial activity of the essential oil from the aerial part of CR.

   • According to Knunta A (2011)

     Excerpt The extracts were vacuum dried & studied for in vitro antifungal activity against Aspergillus niger, Penicillium notatum, Candida albicans, Helminthosporium solani. The present study was undertaken to explore the antifungal potential of different solvent extracts of aerial parts against selected fungal species.

   • According to Morah F (2018)

     Excerpt To determine the chemical constituents, antimicrobial & anthelmintic activities of chloroform fraction of the ethanol extract of the aerial part of Cleome rutidosperma. The antimicrobial sensitivity test was carried out using agar disc diffusion method while broth dilution method was used to determine the minimum inhibitory, minimum bactericidal & minimum fungicidal concentrations.

   • According to Ragavan MR (2018)

     Excerpt The present study was aimed to analyze the phytochemicals of leaf extracts of Cleome rutidosperma & to check their antioxidant, antimicrobial & anticancer activities using in vitro methods. Antibacterial activity of the prepared extracts was performed against Bacillus cereus, Staphylococcus aureus, Escherichia coli & Salmonella typhi.

   • According to Khuntia A (2022)

     Excerpt The potential biological actions & pharmacological effects, such as analgesic, anti-inflammatory, antipyretic, anti-diabetic, antidepressant, antibacterial, anti-arthritic, anticancer, & hepatoprotective are closely related to the active substances contained in various parts of the plants. By centralizing medical data provided by the scientific literature, we offer in the present work a comprehensive perspective on a wide range of bioactive compounds identified from diverse Cleome species, emphasizing the correlation of natural active substances with potential pharmacological activities that can contribute to the improvement of therapeutic management for a range of pathologies.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.