Cleome spinosa (Gwo Mouzanmbé) : medicinal properties in alcoholic extraction

Cleome spinosa (Gwo Mouzanmbé, Gwo kaya, Mouzanmbé sis fèy, cat’s moustache, Gros Mouzambé, Big Acaya, Six-leaved Mouzambé, Cat’s-whisker, moustach-chat, Gros Acaya, Mouzambé-à-six feuilles, Moustache-à-chat) — family Capparacées.

Scientific synonyms : Cleome heptaphylla L., C pubescens Sims, Neocleome spinosa (Jacq.) Small, C spinosa-SW, C tonduzii-Briq, Tarenaya spinosa (Jacq.) Raf.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 21 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver, breast and prostate cancer

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abkari (2015)

     Excerpt This study aimed to evaluate the effects of (CS) fruit extract on NASH compared to fenofibrate & explored the related molecular mechanism.Results: In the rats (n = 40) model of NASH, biochemical and histopathological examinations showed that liver steatosis, inflammation, & hepatic fibrosis were markedly attenuated in response to CS & fenofibrate interventions. In conclusion, CS has favorable therapeutic effects for NASH, which was associated with ameliorating steatosis & fibrosis via regulation of the DNL & β-oxidation pathway genes.

   • According to Jayaprakash AP (2016)

     Excerpt In this present context, one traditional medicinal plant namely Cleome viscosa was selected & its antioxidant effect by DPPH, ABTS & Nitric oxide scavenging assay methods, cytotoxic & in vitro anticancer effects in different fractions of solvent were evaluated phyto-constituents.The results of studies show that the plant has good antioxidant activity low cytotoxic effect & good anticancer properties. viscosa has less cytotoxic activity compared to other extracts & also Cleome viscose whole plant ethyl acetate fraction showed potent toxicity with CTC50 of 130.00±8.66 µg/ml.

   • According to McNeil MJ (2010)

     Excerpt Five different essential oil extractions of the aerial parts of Cleome spinosa Jacq were examined. The oils obtained by hydrodistillation of the whole aerial parts, aerial parts without flowers (fruit, leaves and stem), flowers, fruits & leaves have been examined by GC-FID and GC-MS.

2. 2

   Bacterial infection: Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to da Silva APS (2016)

     Excerpt Additionally, antimicrobial & combinatory effects with oxacillin were assessed against eight clinical isolates of Staphylococcus aureus. aureus & their phenolic (r = −0.89) & flavonoid content (r = −0.87), reinforcing the possible role of these metabolite classes on the antimicrobial activity of CS derived extracts.

   • According to Muniz Dos-Santos FM (2019)

     Excerpt Methods: The bacterial Escherichia coli, Staphylococcus aureus & Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. To evaluate the antibacterial activity & neuroprotective capacity of the ethanolic & aqueous extracts of Tarenaya spinosa as well as to determine & quantify some of its polyphenols by high performance liquid chromatography with diode-array detection (HPLC-DAD).

   • According to Sant' Anna da Silva A (2016)

     Excerpt Due to the use of Cleome spinosa in traditional medicine against inflammatory & infectious processes, this study evaluated the in vitro antimicrobial potential & phytochemical composition of extracts from its roots & leaves. Additionally, antimicrobial & combinatory effects with oxacillin were assessed against eight clinical isolates of Staphylococcus aureus.

   • According to da Silva APS (2016)

     Excerpt Due to the use of Cleome spinosa in traditional medicine against inflammatory & infectious processes, this study evaluated the in vitro antimicrobial potential & phytochemical composition of extracts from its roots & leaves. Additionally, antimicrobial & combinatory effects with oxacillin were assessed against eight clinical isolates of Staphylococcus aureus.

   • According to Santos DA (2005)

     Excerpt Considering these indications and using pharmacological methodologies, this study evaluated the antinociceptive and anti-inflammatory potential of the methanolic extract from aerial parts of Cleome spinosa (EMCS) & flavonoids compounds F10-16 & F11-13, orally administered, and the mechanisms of action involved. Some flavonoids showed anti-oxidant, antifungal, antibacterial, antimutagenic & anti-spasmodic activity.

3. 3

   Fungal infection: Candida albicans, C. krusei and C. tropicalis

   Plant part used: Sheet. Mentioned synergistic association: Fluconazole.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to da Silva APS (2016)

     Excerpt spinosa different extracts were obtained (cyclohexane: ChL & ChR; chloroform: CL & CR; ethyl acetate: EAL & EAR, methanol: ML & MR). The antimicrobial activity was evaluated by the broth microdilution method to obtain the minimum inhibitory (MIC) & microbicidal (MMC) concentrations against 17 species, including bacteria & yeasts.

   • According to Rodriguez FC (2019)

     Excerpt The IC50 results demonstrated that the combination of the extracts with fluconazole were more significant than the products tested alone, with values from 4.9 to 34.8 μg/mL for the ethanolic extract/fluconazole & 5 to 84.7 μg/mL for the aqueous extract/fluconazole. The effect of the combination extract/fluconazole was verified by microdilution, with the extracts in subinhibitory concentrations (MFC/16).

   • According to McNeil MJ (2010)

     Excerpt spinosa found in Jamaica & the in vitro antioxidant, insecticidal & antimicrobial potential of the oil from the aerial parts. Five different essential oil extractions of the aerial parts of Cleome spinosa Jacq were examined.

   • According to Sant' Anna da Silva A (2016)

     Excerpt Due to the use of Cleome spinosa in traditional medicine against inflammatory & infectious processes, this study evaluated the in vitro antimicrobial potential & phytochemical composition of extracts from its roots & leaves. The antimicrobial activity was evaluated by the broth microdilution method to obtain the minimum inhibitory (MIC) & microbicidal (MMC) concentrations against 17 species, including bacteria & yeasts.

   • According to Muniz Dos-Santos FM (2019)

     Excerpt To evaluate the antibacterial activity & neuroprotective capacity of the ethanolic & aqueous extracts of Tarenaya spinosa as well as to determine & quantify some of its polyphenols by high performance liquid chromatography with diode-array detection (HPLC-DAD). Conclusions: Although it does not present an antibacterial action, the extracts of TS can be used in the pharmaceutical industries since its extracts show modulating action of drugs.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.