Cleome viscosa (Ti-kaya jôn) : medicinal properties in alcoholic extraction

Cleome viscosa (Ti-kaya jôn, Ti Mouzanmbé, Little yellow Acaya, little Mouzambé, Petit Acaya jaune, petit Mouzambé) — family Capparacées.

Scientific synonyms : Cleome icosandra-L, Polanisia viscosa-(L)-DC, Polanisia icosandra-(L)-W & A.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 16 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 39 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic neuropathy, sciatica

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rao BS (2014)

     Excerpt In the present study, we investigated the neuroprotective effect of ethanolic extract of Cleome viscosa (EECV) against streptozotocin (STZ) induced diabetic neuropathy in Wistar rats. Diabetic neuropathy (DN) is a secondary microvascular complication of diabetes causing damage to the nerves and is characterized by fall in nerve conduction velocity, severe pain, impaired sensation and degeneration of nerve fibres.

   • According to Yarrappagaari S (2020)

     Excerpt The current research is to develop an easy & eco-friendly method for the synthesis of three different concentrations of silver nanoparticles (1mMCvAgNPs, 2mMCvAgNPs & 3mMCvAgNPs) using aqueous whole plant extract of Cleome viscosa & to evaluate their antibacterial, antioxidant & antidiabetic properties. Hence, to validate our results, the in vivo studies at the molecular level are needed to develop CV as an antibacterial, antioxidant & anti-diabetic agent.

2. 2

   Liver detoxification, liver fibrosis

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kumar SV (2009)

     Excerpt The liver weight that increased following CCl4 administration due to déposition of Collagen was reduced by the ethanolic extract C viscosa L. Liver fibrosis is the excessive accumulation of extracellular matrix proteins including Collagen that occurs in most types of chronic liver diseases.

   • According to Nguyen TP (2017)

     Excerpt At the concentration of 25 μM and 50 μM, 1 showed cytotoxic activity against HepG2 cells (cell viability was decreased to 22.2 & 23.0%, respectively, compared with doxorubicin control), while at the concentration of 100 μM, 1 showed hepatoprotective activity against CCl4-induced hepatotoxicity on HepG2 cells (34.3%, compared with quercetin control).-OJOGBANE et al, Acute toxicity & histopathological assessment of methanolic extract of Cleome viscosa Linn whole plant, Planta Medica, 80 :10, 2014.-Abstract : Cleome viscosa Linn (Cleomaceae) is a medicinal plant used widely in ethnomedicine. One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rhamnopyranoside (5), kaempferol 7-O-α-l-rhamnopyranoside (6), kaempferitrin (7) and kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (8) were isolated by various chromatography methods from the leaves of Cleome viscosa, Their structures were elucidated by IR, UV, HR-ESI-MS & NMR (1D & 2D) experiments.

   • According to DAHIYA V (2014)

     Excerpt Aim: This study was carried out to investigate the Chemopreventive effects of ethanolic extract of Cleome viscosa (EECV) on mutagenicity & hepatotoxicity caused by Benzo(a)Pyrène. Results: The activities of serum aminotransferases & the hepatic content of lipid peroxides were increased whereas liver antioxidants, such as glutathione (GSH), glutathione peroxidase (GPx), glutathione réductase (GR) were decreased in B(a)P-treatment group than control, but all these levels were significantly and dose dependently reversed by the treatment with EECV.

   • According to Kumar Mobiya A (2010)

     Excerpt In present study, Hepatoprotective activity of the ethanolic extract of Cleome Viscosa L. The hepatoprotective effect was evaluated on the basis of liver function parameters viz serum total Bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities.

   • According to Nguyen TP (2017)

     Excerpt One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rhamnopyranoside (5), kaempferol 7-O-α-l-rhamnopyranoside (6), kaempferitrin (7) & kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (8) were isolated by various chromatography methods from the leaves of Cleome viscosa, Their structures were elucidated by IR, UV, HR-ESI-MS & NMR (1D & 2D) experiments. At the concentration of 25 μM and 50 μM, 1 showed cytotoxic activity against HepG2 cells (cell viability was decreased to 22.2 & 23.0%, respectively, compared with doxorubicin control), while at the concentration of 100 μM, 1 showed hepatoprotective activity against CCl4-induced hepatotoxicity on HepG2 cells (34.3%, compared with quercetin control).

3. 3

   Type II diabetes mellitus

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Rao BS (2014)

     Excerpt In the present study, we investigated the neuroprotective effect of ethanolic extract of Cleome viscosa (EECV) against streptozotocin (STZ) induced diabetic neuropathy in Wistar rats. Diabetic neuropathy (DN) is a secondary microvascular complication of diabetes causing damage to the nerves and is characterized by fall in nerve conduction velocity, severe pain, impaired sensation and degeneration of nerve fibres.

   • According to Yarrappagaari S (2020)

     Excerpt The current research is to develop an easy & eco-friendly method for the synthesis of three different concentrations of silver nanoparticles (1mMCvAgNPs, 2mMCvAgNPs & 3mMCvAgNPs) using aqueous whole plant extract of Cleome viscosa & to evaluate their antibacterial, antioxidant & antidiabetic properties. Hence, to validate our results, the in vivo studies at the molecular level are needed to develop CV as an antibacterial, antioxidant & anti-diabetic agent.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.