Clerodendrum philippinum (The Character of Man) : medicinal properties in alcoholic extraction

Clerodendrum philippinum (The Character of Man, Karaktè-dézonm, caractère-des-Hommes) — family Verbénacées.

Scientific synonyms : Agricolaea fragrans (V.) Schrank, Clerodendrum chinense var. hamrense Das, S & B, C chinense var. parviflorum M.R.A, C chinense var. plenum M.R.Almeida, C chinense var. simplex (M) S.L.Chen, C fragrans Willd., C fragrans f. pleniflorum (Schauer) Standl. & Steyerm., C fragrans var. pleniflorum Schauer, C japonicum (Jacq.) G, C lasiocephalumC.BC, C macradenium-Miq, C philippinum f. subfertile Moldenke, C riedelii Oliv., C roseum Poit., Cryptanthus chinensis Osbeck, Ovieda fragrans (V.) H., Volkameria fragrans Vent., V japonica Jacq..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 52 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, Bacillus subtilis, Corynebacterium kroppenstedtii and Vibrio cholerae

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pranati D (2018)

     Excerpt Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia, Bacillus subtilis, Corynebacterium kroppenstedtii & Vibrio cholerae by disc diffusion method. Clerodendrum philippinum plant was evaluated for its secondary metabolites & antibacterial activity.

   • According to Venkatanarasimman B (2012)

     Excerpt Roots & leaf extracts of Clerodendrum philippinum have been used for the treatment of rheumatism, asthma & other inflammatory diseases. aureus, Bacillus & Klebsiella & minimum inhibitory concentration of CP.

   • According to Nababan JL (2021)

     Excerpt The results of antibacterial test against the oral bacteria Streptococcus mutans ATCC (25175) showed that 0.5% & 0.75% of the oral antibacterial mouthwash was found to be effective as oral antibacterial with an average inhibition zone diameter of 16.55 & 16.9 mm. Clerodendrum fragrans is a local plant of North Sumatra, containing secondary metabolites of alkaloids, steroids, flavonoids, triterpenoids, saponins, tannins, & quinones that have bioactivity such as antibacterial & antioxidant.

   • According to Simorangkir M (n.d.)

     Excerpt Sarang banua plant, known as Clerodendrum fragrans is a division of the Verbenaceae family found in Simalungun district of Indonesia, which is traditionally used as medicinal plants. aureus (90.0%) with inhibitory zones of 11.25 ± 0.2 mm, meanwhile the n-hexane (non-polar) extract had the greatest inhibition against Gram-negative bacteria of the E.

   • According to Lalitha KG (2017)

     Excerpt The research work deals with the ethanolic extract of Clerodendrum philippinum flowers for anti-anxiety & central nervous system depressant activity. The CP flowers are known to contain sterols, flavonoid, glycosides & phenyl propanoid derivatives as chemical components & are reported to have antifungal activity.

2. 2

   - cancer: adjuvant treatment of breast, lung and uterine carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chittasupho C (2023)

     Excerpt This study aims to investigate the antioxidant & anti-cancer activities of Clerodendrum chinense leaf ethanolic extract. CC leaf extract exhibited anti-proliferative activity against A549 lung cancer cells in a dose- & time-dependent manner, with the IC50 value of 340.63 ± 89.43, 210.60 ± 81.74, and 107.08 ± 28.90 µg/mL after treatment for 24, 48, and 72 h, respectively.

   • According to Barung EN (2021)

     Excerpt RESULTS: The results showed that ethanol extract, hexane fraction, ethyl acetate fraction, & water-soluble fraction of CF had anticancer activity on A549 lung cancer cells. fragrans leaves obtained in Malalayang I Timur Village, Malalayang District, Manado City, North Sulawesi Province, while the subjects in this study were A549 lung cancer cells from Cell-Culture Laboratory, Faculty of Pharmacy, Universitas Padjadjaran Bandung.

   • According to Gogoi B (2017)

     Excerpt Clerodendrum indicum & Clerodendrum serratum are reported to have anticancer activity; therefore, a study was carried out to identify selective anticancer agents from these plants’ species. We predicted five compounds, namely apigenin 7-glucoside, hispidulin, scutellarein-7-O-beta-D-glucuronate, acteoside & verbascoside, to be potential binding therapeutics for cancer target proteins.

   • According to Qi J (2021)

     Excerpt As part of our continuing efforts toward the discovery of the biologically active diterpenoids from medicinal plants, six new C-ring aromatized abietane diterpenoids, clerodenoids A—F (1—6), were isolated from Clerodendrum chinense. Compounds 5 & 6 displayed strong antiproliferative activities against A549 & HL-60 cell lines.

   • According to Kalonio DE (2017)

     Excerpt Kalonio DE et al, Anticancer activity of plants of the genus Clerodendrum (Lamiaceae).

3. 3

   Cancer: adjuvant treatment for lung cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Barung EN (2021)

     Excerpt RESULTS: The results showed that ethanol extract, hexane fraction, ethyl acetate fraction, & water-soluble fraction of CF had anticancer activity on A549 lung cancer cells. fragrans leaves obtained in Malalayang I Timur Village, Malalayang District, Manado City, North Sulawesi Province, while the subjects in this study were A549 lung cancer cells from Cell-Culture Laboratory, Faculty of Pharmacy, Universitas Padjadjaran Bandung.

   • According to Chittasupho C (2023)

     Excerpt This study aims to investigate the antioxidant & anti-cancer activities of Clerodendrum chinense leaf ethanolic extract. CC leaf extract exhibited anti-proliferative activity against A549 lung cancer cells in a dose- & time-dependent manner, with the IC50 value of 340.63 ± 89.43, 210.60 ± 81.74, and 107.08 ± 28.90 µg/mL after treatment for 24, 48, and 72 h, respectively.

   • According to Qi J (2021)

     Excerpt As part of our continuing efforts toward the discovery of the biologically active diterpenoids from medicinal plants, six new C-ring aromatized abietane diterpenoids, clerodenoids A—F (1—6), were isolated from Clerodendrum chinense. Compounds 5 & 6 displayed strong antiproliferative activities against A549 & HL-60 cell lines.

   • According to Gogoi B (2017)

     Excerpt Clerodendrum indicum & Clerodendrum serratum are reported to have anticancer activity; therefore, a study was carried out to identify selective anticancer agents from these plants’ species. We predicted five compounds, namely apigenin 7-glucoside, hispidulin, scutellarein-7-O-beta-D-glucuronate, acteoside & verbascoside, to be potential binding therapeutics for cancer target proteins.

   • According to Kalonio DE (2017)

     Excerpt Kalonio DE et al, Anticancer activity of plants of the genus Clerodendrum (Lamiaceae).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.