Coccinia indica (Ti-konkonb-Lyenn) : medicinal properties in alcoholic extraction

Coccinia indica (Ti-konkonb-Lyenn, Ti-Goud, Small vine cucumber, Small gourd, Petite concombre-liane, Petite gourde) — family Cucurbitacées.

Scientific synonyms : Coccinia grandis-(L)-Voigt..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 69 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shibib BA (2012)

     Excerpt To explore how ethanolic extract of Coccinia indica affects normal & diabetic rats. CONCLUSION :Results suggested that CI extract had anti-hyperglycaemic & anti-ureogenic effects on the diabetic rats as judged by the decreased level of blood glucose & fatty acid & hepatic arginase activity,.

   • According to Venkateswaran S (2003)

     Excerpt The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase & glutathione-S-transferase in liver & kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt.

   • According to Venkateswaran S (2003)

     Excerpt The present study was carried out to investigate the antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic Medicine in India, in Streptozotocin-diabetic rats. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.

   • According to Kumar Balaraman A (2010)

     Excerpt Antihyperglycemic & hypolipidemic effects of ethanol extract of aerial parts of Melothria maderaspatana & Coccinia indica were evaluated in STZ induced diabetes in Sprague-Dawley rats. Administration of EEMm or EECi to STZ-diabetic rats caused significant antihyperglycemic & hypolipidemic effects (p < 0.001).

   • According to Mohammed S Iqbal (2016)

     Excerpt Results: Treatment of experimental rats with diabetes induced by streptozotocin by ethanolic leaf extract (500 mg/kg) caused significant (P < 0.001) reduction in blood glucose (312–169 mg/100 mL), increase in body weight (181–210 g) & serum insulin (1.28–3.10 IU/dL). to evaluate antidiabetic & antioxidative properties of Coccinia grandis leaf extract in experimental diabetic rats & to study the co-relation of the two in vivo.

2. 2

   Congestive liver disease, hepatocardiac disorder

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vinoth-Kumar G (2019)

     Excerpt Coccinia indica is indigenous plant wildly used in traditional medicinal system including Ayurvedic, Siddha & Unani. In this study, the protective effect of CI leaf extract against enalapril induced hepatotoxicity proves, the plant has many medicinal properties.

   • According to Shibib BA (2012)

     Excerpt To explore how ethanolic extract of Coccinia indica affects normal & diabetic rats. CONCLUSION :Results suggested that CI extract had anti-hyperglycaemic & anti-ureogenic effects on the diabetic rats as judged by the decreased level of blood glucose & fatty acid & hepatic arginase activity,.

   • According to Kumar Balaraman A (2010)

     Excerpt Antihyperglycemic & hypolipidemic effects of ethanol extract of aerial parts of Melothria maderaspatana & Coccinia indica were evaluated in STZ induced diabetes in Sprague-Dawley rats. After 14 days experimental period, rats were sacrificed by cervical decapitation, blood & liver samples were collected.

   • According to Jamwal A (2019)

     Excerpt Coccinia indica Wight. Quercetin caused slight change in hepatic marker enzymes and kidney functions markers in diabetic rats.

   • According to Attanayake A (2016)

     Excerpt Leaves of ivy gourd; Coccinia grandis (L.) Voigt (Family: Cucurbitaceae) is one of the well-known leafy vegetables, which has been consumed by Sri Lankans for centuries. In addition, the optimum effective therapeutic dose of the aqueous CG extract was found to be safe in terms of hepatotoxicity, renotoxicity, hematotoxicity in vivo.

3. 3

   Bacterial infection: Enterobacter aerogenes, Pseudomonas aeruginosa, Staphylococcus epidermidis, Bacillus subtilis and Salmonella typhimurium

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hussain A (2010)

     Excerpt The aqueous & organic solvent (Petroleum ether, chloroform & ethanol) extracts from the leaves of CI(Cucurbitaceae) were tested against Enterobacter aerogenes, Pseudomonas aeruginosa, Staphylococcus epidermidis, Bacillus subtilis & Salmonella typhimurium by agar well diffusion method & broth dilution method. The aim of the present research was focused on investigating the antibacterial & preliminary phytochemical properties of Coccinia indica (W.A.) via in vitro approach.

   • According to Sakharkar P (2017)

     Excerpt The antibacterial activities of the extracts were tested against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli & Pseudomonas aeruginosa using the modified Kirby-Bauer diffusion method & compared against erythromycin. Little knowledge is available on the antimicrobial and antioxidant properties of Coccinia grandis fruits & no study has reported on its cell proliferative property.

   • According to Al-Madhagy SA (n.d.)

     Excerpt CG50 hydrogel showed a pronounced inhibition of the bacterial growth in wounds infected by Bacillus cereus in rats comparable to those treated with hydrogel base only showing 85.08 & 16.50% inhibition for the bacterial growth for the CG50 hydrogel & hydrogel base, respectively. A polyphenolic-rich fraction (CG50) was obtained from the methanol extract of Coccinia grandis leaves by chromatographic fractionation over a Diaion column using 50% aqueous methanol.

   • According to Chinni SV (2021)

     Excerpt the present study was planned to characterize & analyze the antimicrobial activity of silver nanoparticles (AgNP) biosynthesized using a Coccinia indica leaf (CIL) ethanolic extract. The biogenic AgNP & CIL extracts were further investigated against different bacterial strains for their antimicrobial activity.

   • According to Rahman FL (n.d.)

     Excerpt In this present study, the leaf extracts of Coccinia grandis L., were subjected to evaluation of the phytochemical screenings, thrombolytic, membrane stabilizing, antioxidant, antimicrobial & cytotoxic activity. Leave extracts of CG revealed moderate antimicrobial activity against some gram positive and gram negative microorganisms.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.