Coix lacryma (Grenn Jôb) : medicinal properties in alcoholic extraction

Coix lacryma (Grenn Jôb, Job’s Seeds, Graines de Job) — family Poacées.

Scientific synonyms : Coix lacryma-jobi var. mayuen, orth. Var, C var. ma-yuen (Rom.Caill.) Stapf.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 24 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 116 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of liver, gastric and uterine carcinoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Devaraj RD (2020)

     Excerpt Coix seed constituents have strong antioxidant, anti-inflammatory, anti-obesity activity, stimulate reproductive hormones, promote uterine contraction & modulate gut microbiota. Coix has strong chemical constituents to inhibit enzymes of cyclooxygenase (COX), fatty acid synthase, matrix metalloproteinases & liver cholesterol synthesis.

   • According to He W (2020)

     Excerpt Adlay (Coix lacryma-jobi L.) bran has recently attracted much attention because it is rich in neutral oil, which promises its potential usage as a health-promotion product. The results proved that crude ABO extracted by the ethanol-water method probably had a potential higher anticancer function than Kanglaite® injection.

   • According to LI H (2024)

     Excerpt Numerous pharmacological effects of Coix seed have been demonstrated through modern pharmacological studies, such as hypoglycemia, improving liver function, anti-tumor, regulating intestinal microbiota, improving spleen function, & anti-inflammatory effects. In addition to its anti-tumor effect, it also has pharmacological effects such as hypoglycemia, improving liver function, regulating intestinal microbiota, improving spleen function, & anti-inflammatory effects.

   • According to Gu L (2021)

     Excerpt Coix lacryma-job seed oil (CLSO) is an active component extracted from Coix lacryma-jobi seed (CLS) which has been found to be effective of reducing blood fat & antioxidative. Our result showed that CLSO decreased the liver/body weight ratio, lowered the total cholesterol (TC) & triacylglycerol (TG), & elevated the high-density lipoprotein (HDL) in serum.

   • According to HUANG CC (2021)

     Excerpt Coix lacryma-jobi var. The results indicates that AB-SCF displays a prevention of dramatic body weight gains, lower levels of serum TG, TC, LDL-C & higher in HDL-C, amelioration of cardiovascular risk, alleviation of hepatic TG, TC & lipid peroxidation, & enhancement on cholesterol metabolism with higher bile acid excretion.

2. 2

   Non-alcoholic fatty liver disease (NAFLD)

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Gu L (2021)

     Excerpt The lipid metabolism disorder is the key role of Nonalcoholic fatty liver disease (NAFLD). Coix lacryma-job seed oil (CLSO) is an active component extracted from Coix lacryma-jobi seed (CLS) which has been found to be effective of reducing blood fat & antioxidative.

   • According to He W (2020)

     Excerpt Adlay (Coix lacryma-jobi L.) bran has recently attracted much attention because it is rich in neutral oil, which promises its potential usage as a health-promotion product.

   • According to Devaraj RD (2020)

     Excerpt Coix has strong chemical constituents to inhibit enzymes of cyclooxygenase (COX), fatty acid synthase, matrix metalloproteinases & liver cholesterol synthesis. The annual millet Coix lacryma-Jobi L.

   • According to LI H (2024)

     Excerpt Numerous pharmacological effects of Coix seed have been demonstrated through modern pharmacological studies, such as hypoglycemia, improving liver function, anti-tumor, regulating intestinal microbiota, improving spleen function, & anti-inflammatory effects. Coix lacryma-jobi var.

   • According to HUANG CC (2021)

     Excerpt Coix lacryma-jobi var. The results indicates that AB-SCF displays a prevention of dramatic body weight gains, lower levels of serum TG, TC, LDL-C & higher in HDL-C, amelioration of cardiovascular risk, alleviation of hepatic TG, TC & lipid peroxidation, & enhancement on cholesterol metabolism with higher bile acid excretion.

3. 3

   High blood pressure, fluid retention, oedema

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ouyang Y (2022)

     Excerpt The data generated from this study revealed the characteristic diversity of Coix collected from different locations, which will facilitate the utilization of antihypertensive peptides from glutelin –. Coix lacryma-jobi L.

   • According to Zhang CF (2019)

     Excerpt Results: The values of paw oedema, PGE2 & MMP-3 decreased from 1.46 ± 0.04 to 0.66 ± 0.07 cm3, from 126.2 ± 11.48 to 79.71 ± 6.8 pg/mL & from 142.7 ± 8.36 to 86.51 ± 5.95 ng/mL, respectively; the values of body weight increased from 177.25 ± 5.94 to 205 ± 6.52 g in HASE group. In addition, treatment of ASE reduced the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, MCP-1), & increased the activities of antioxidant enzyme (GSH-Px, SOD, & CAT).

   • According to Huang DW (2009)

     Excerpt Subfractions AHE-Ea-J, AHE-Ea-K, & AHE-Ea-M had anti-inflammatory activities, as they counteracted the increased cellular production of nitric oxide & prostaglandin E2 induced by lipopolysaccharide by down-regulating inducible nitric oxide synthase & cyclooxygenase 2 expression. Eriodictyol (1), the ceramide (2S,3S,4R)-2-[(2'R)-2'-hydroxytetracosanoyl-amino]-1,3,4-octadecanetriol (2), & p-coumaric acid (3) were found in the subfractions, & the first two compounds appeared to be primarily responsible for the anti-inflammatory activity.

   • According to Li SC (2011)

     Excerpt Previous studies have shown that adlay has anti-tumour & anti-inflammatory activity.

   • According to Devaraj RD (2020)

     Excerpt Coix seed constituents have strong antioxidant, anti-inflammatory, anti-obesity activity, stimulate reproductive hormones, promote uterine contraction & modulate gut microbiota. The annual millet Coix lacryma-Jobi L.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.