Coriandrum sativum (Coriander) : medicinal properties in alcoholic extraction

Coriandrum sativum (Coriander, Coriandre) — family Apiacées.

Scientific synonyms : Apium leptophyllum auct non (Pers.) Muell ex Benth, Coriandrum diversifolium Gilib., C. globosum Salisb, C. majus Gouan, C. melphitense Ten. & Guss., Selinum Coriandrum E.H.L. Krause.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 25 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 142 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Normalisation of serum parameters: SGOT, SGPT, ALP, bilirubin

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sharma B (2016)

     Excerpt Results: After 28 days treatment the extracts significantly (p<0.001) reduce serum glucose level and recovered liver function tests (p<0.001) (SGOT, SGPT, ALP & Bilirubin) as well glycosylated haemoglobin (p<0.001). The aim of the present study was to evaluate the antidiabetic & hepatoprotectivity of ethanolic extracts of Coriandrum sativum in alloxan induced diabetic rat & find out the harmonious activity of the extract.

   • According to Pandey A (2011)

     Excerpt Materials & methods: This study was aimed at investigating the hepatoprotective activity of CS against carbon tetrachloride (CCl4), with estimation of serum glutamyl oxaloacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALP) & bilirubin, & with liver histopathology. CS signifies hepatoprotection by reducing the liver weight, activities of SGOT, SGPT, & ALP, & direct bilirubin of CCl (4) intoxicated animals.

   • According to Talaei R (n.d.)

     Excerpt Treatment with CS extract significantly decreased bio- chemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) & creatine phosphokinase (CPK), & improved tissue damage & decreased iron accumulation in the liver compared to the iron overload group (P < 0.05). Conclusions: The study showed that the hydro-alcoholic extract of C.S has iron-chelating & liver protective effects similar to deferoxamine against experimental iron overload condition in rats,.

   • According to Kansal Leena (2011)

     Excerpt Treatment with coriander significantly reduced the adverse effects related to most of biochemical parameters altered in animals treated with lead, related to hepatic & renal oxidative stress. The effect of these treatments in influencing the lead induced changes on hepatic and renal oxidative stress and biochemical changes along with histopathological alterations in soft tissues was studied.

   • According to Mostafa Saeed (2014)

     Excerpt The possible protective effect of Coriandrum sativum seeds methanolic extract on hepatorenal toxicity induced by sodium arsenite in albino rats.

2. 2

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sharma B (2016)

     Excerpt The aim of the present study was to evaluate the antidiabetic & hepatoprotectivity of ethanolic extracts of Coriandrum sativum in alloxan induced diabetic rat & find out the harmonious activity of the extract. Methods: The alloxan (150 mg/kg, i.p) used for induction of diabetes after making diabetic model the ethanolic extract of C sativum leaves used at a dose of 200 a&400 mg/kg b.w.

   • According to Aligita W (2018)

     Excerpt Diabetes mellitus is one of the metabolic disorders marked by hyperglycemia caused by carbohydrate, fat, & protein metabolism abnormality. There is a significant increase in diabetes case every year in Indonesia & the long-term use of antidiabetic drugs can cause various side effects.

   • According to Sharma B (2017)

     Excerpt To evaluate the antidiabetic & rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of Coriandrum sativum. The effect of ethanolic leaf extract of CS leaf extract on serum blood glucose, insulin, lipase, α- amylase & LDH as well as kidney function test [urea, uric acid, albumin, protein & creatinine] were measured in the alloxan induced diabetic rats.

   • According to Eldi M (n.d.)

     Excerpt In the present study, an ethanol extract of the seeds was investigated for effects on insulin release from the pancreatic beta cells in streptozotocin-induced diabetic rats. Administration of streptozotocin decreased the number of beta cells with insulin secretory activity in comparison with intact rats, but treatment with the CS seed extract (200 mg/kg) increased significantly the activity of the beta cells in comparison with the diabetic control rats.

   • According to Aissaoui A (2011)

     Excerpt Results: A single dose of CS-extract or GLB suppressed hyperglycemia in OHH rats, & normo-glycemia was achieved at 6-h post-dose; there was no effect on lipids, TG or insulin, but IR decreased significantly. The use of an aqueous extract of Coriandrum sativum seeds (CS-extract) in Moroccan traditional treatment of diabetes remains to be experimentally validated.

3. 3

   Bacterial infection: S. aureus, Bacillus humilis, Klebsiella pneumoniae, E. coli, Pseudomonas aeruginosa, S. typhi

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Matasyoh JC (2009)

     Excerpt The oil was screened for antimicrobial activity against both Gram positive (Staphylococcus aureus, Bacillus spp.) & Gram negative (Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Proteus mirabilis, Pseudomonas aeruginosa) bacteria & a pathogenic fungus, Candida albicans. The oil showed pronounced antibacterial & antifungal activity against all of the microbes tested, except for P.

   • According to Bakhiet O (2006)

     Excerpt Petroleum ether, ethanolic and water extracts of Petroselinum sativum and Coriandrum sativum were screened for antibacterial activity against one standard gram-positive bacterium (Staphylococcus aureus) & three gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa & Salmonella typhi). sativum was active against only Pseudomonas aeruginosa.

   • According to Charan AA (2013)

     Excerpt coli, Bacillus pumila, & Klebsiella pneumonia to determine the sample’s antibacterial activity. The present study was carried out to evaluate the antibacterial and antioxidant activity of the crude ethanolic an acetone extracts of Mentha Piperata, Spinacia oleracea & Coriandrum sativum.

   • According to Cao XZ (2012)

     Excerpt Antibacterial experiment indicated that only water extract presented significant antimicrobial activity & the minimum inhibition concentration (MIC) was below 10% of original extract. The results showed that antibacterial activity of coriander extracts was stable under heating & had the best antibacterial effects at pH 6 with 2.0% NaCl concentration,.

   • According to Begnami (2010)

     Excerpt The aim of this study was to evaluate the chemical and antifungal activity of the essential oil from Coriandrum sativum L. In conclusion, the EO and its fractions could be used as potential antimicrobial agents to treat or prevent Candida yeast infections.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.