Costus speciosus (Kann Kongo) : medicinal properties in alcoholic extraction

Costus speciosus (Kann Kongo, Kann dlo, It’s gone flat, Canne-à-Congo, water pipe, Ti dégonflé, canne-d ’eau) — family Costacées.

Scientific synonyms : Banksia speciosa-K, Costus spicatus-(Jacq)-Sw.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 51 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of breast and liver cancer

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to NAIR SVG (2014)

     Excerpt This is the first report to demonstrate in vitro anticancer activity of leaf extract of CS in relation to liver cancer,. speciosus on the growth of human hepatocellular carcinoma (HepG2) cell & understand possible mechanisms of its action.

   • According to Verma N (2009)

     Excerpt The hepatoprotective activity of the ethanolic extract of the rhizomes of Costus speciosus (Koenig) Sm. The extract registered a significant fall in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), serum bilirubin (SBLN) & liver inflammation supported by histopathological studies on liver, thus exhibited a significant hepatoprotective activity.

   • According to Viduranga Y (2015)

     Excerpt Costus speciosus & Coccinia grandis are plants which contain reservoirs of anti-diabetic effects as well as other medicinal properties. These plants have been known to demonstrate pharmacological activities such as anti-inflammatory, anti-microbial, antioxidant, anti-dyslipidemic & anti-cancer.

   • According to Selim S (2015)

     Excerpt Results: The results indicated that the treatment of HepG2 cells with the sample resulted in a cytotoxic effect as concluded from the IC50 value 32.62 μg/ml, while the treatment of HepG2 cells with paclitaxel, a known anti-cancer drug, resulted in an IC50 value of 0.48 μg/ml. Conclusions: The results presented here may suggest that diosgenin isolated from CS possess anticancer & apoptotic effects on cell proliferation, & therefore, can be used as pharmaceuticals drug,.

   • According to Shediwah FM (2019)

     Excerpt An extract of Costus speciosus (CSE), an herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic & ameliorating effects on histopathological changes in atherogenic rabbits. Total protein increased in the liver, heart & aorta after treatment with CSE & also a marked improvement in histopathological parameters was demonstrated.

2. 2

   Liver disorders: abnormal serum levels: SGOT, SGPT, ALKP (alkaline phosphatase), bilirubin, total protein

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Verma N (2009)

     Excerpt The extract registered a significant fall in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), serum bilirubin (SBLN) & liver inflammation supported by histopathological studies on liver, thus exhibited a significant hepatoprotective activity. The hepatoprotective activity of the ethanolic extract of the rhizomes of Costus speciosus (Koenig) Sm.

   • According to NAIR SVG (2014)

     Excerpt Costus speciosus is a medicinal plant commonly known as wild ginger distributed in South and Southeast Asian countries. speciosus on the growth of human hepatocellular carcinoma (HepG2) cell & understand possible mechanisms of its action.

   • According to Reavathy J (2014)

     Excerpt Our experimental findings with respect to the mechanism of action of extract in alloxan induced diabetic rats suggest that it enhances insulin secretion by the islets of Langerhans, enhances peripheral glucose utilization & increases serum protein levels. The antidiabetic effect of ethanolic extract of Costus speciosus rhizome was determined.

   • According to Shediwah FM (2019)

     Excerpt Total protein increased in the liver, heart & aorta after treatment with CSE & also a marked improvement in histopathological parameters was demonstrated. An extract of Costus speciosus (CSE), an herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic & ameliorating effects on histopathological changes in atherogenic rabbits.

   • According to Bavarva JH (2008)

     Excerpt In the present study, the antihyperglycemic, antihyperlipemic & antioxidant potency of an ethanol extract of Costus speciosus root was investigated in alloxan-induced diabetic male (Charles Foster) rats. While the diabetic controls showed significant abnormal carbohydrate, lipid & antioxidant profiles, administration of 150 mg/kg BW dose neither improved glucose nor lipid metabolism & antioxidant levels.

3. 3

   Type II diabetes mellitus

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Daisy P (2008)

     Excerpt rhizome extracts on biochemical parameters in streptozotocin (STZ)-induced male diabetic Wistar rats. Thus, this study shows that the CS hexane extract has antihyperglycemic & hypolipidemic activity, is able to ameliorate the diabetic state & is probably a source of hypoglycemic compounds.

   • According to Reavathy J (2014)

     Excerpt The antidiabetic effect of ethanolic extract of Costus speciosus rhizome was determined. Our experimental findings with respect to the mechanism of action of extract in alloxan induced diabetic rats suggest that it enhances insulin secretion by the islets of Langerhans, enhances peripheral glucose utilization & increases serum protein levels.

   • According to Revathy J (2011)

     Excerpt Revathy J et al, An experimental evaluation of the antidiabetic & antioxidant effect of Costus speciosus rhizome extract in alloxan-induced albino rat, BioSci Biotechnol Res Asia, 2011-.

   • According to Eliza J (2011)

     Excerpt Normalizing effects of Costus speciosus rhizome crude extracts & its fractions on diabetic complications in STZ-induced diabetic rats.

   • According to Ferosakhan M (n.d.)

     Excerpt It is concluded from the present study that the Costus species extracts potentiate the antidiabetic activity & can be used as an alternate for the treatment of diabetes after completing successful clinical trials. Fresh elder leaves of species viz., Costus pictus & Costus speciosus were collected from Western Ghats, Tamil Nadu.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.