Costus spicatus (Kann Kongo) : medicinal properties in alcoholic extraction

Costus spicatus (Kann Kongo, Kann dlo, Ti dégonflé, Canne-à-Congo, water cane, Little deflator, canne-d ’eau, Petit dégonflé) — family Costacées.

Scientific synonyms : Alpinia spicata-Jacq, Amomum petiolatum-Lam, Costus cylindrica-Aubl non L, C micranthus -Gag..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 20 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sivalungam MA (2019)

     Excerpt Anti-diabetic effect of plant Costus spicatus. ECS & Glibenclamide of STZ induced diabetic animals restored the normal plasma glucose levels & SGOT, SGPT & ALP levels without damaging the pancreas.

   • According to Femi-Olabisi F (2021)

     Excerpt In this study, the inhibitory activities of phytosterols & saccharides from aqueous extract of Costus spicatus rhizome were investigated against phosphoenol-pyruvate carboxykinase (PEPCK), α-amylase, β-glucosidase, & fructose 1,6-biphosphatase (FBPase) in silico as potential novel therapeutic targets for T2DM-associated-PCOS. Insulin resistance is the hall mark of PCOS as it predisposes the affected subjects to a higher risk of impaired glucose tolerance & type 2 diabetes mellitus (T2DM).

   • According to Sivalungam AM (2021)

     Excerpt The characteristic phytochemical constituents are steroids, tri-terpenoid, Anthraquinone glycosides, proteins are established in the concentrates of Costus spicatus flower. Oral administration of effect of ECS to diabetic induced rats at dosage of 500 mg/kg body weight resulted during significant decrease of elevated blood glucose & hepatic transaminase enzyme levels, at different treatment period (0 th day, 28 th day & 45 th day) which also showed the structural changes in cytoarchitecture of STZ induced diabetic rats.

   • According to Sivalungam MA (2023)

     Excerpt The study found that Costus spicatus extract had a beneficial effect on body weight & blood glucose levels in diabetic rats. The study found that the CS leaf extract was effective in improving the antioxidant activity of important parameters such as SOD, CAT, GPx, & GR, & protected against hyperglycemia and oxidative damage in type 2 diabetes-induced hepatorenal functions both in vitro & in vivo .

   • According to Keller AC (2009)

     Excerpt More investigation is needed to more fully explore dosages & the possible utility and biological activity of this common Dominican herbal remedy for the treatment of type 2 diabetes mellitus. Insulina was identified as Costus spicatus.

2. 2

   Type II diabetes mellitus

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sivalungam AM (2021)

     Excerpt The characteristic phytochemical constituents are steroids, tri-terpenoid, Anthraquinone glycosides, proteins are established in the concentrates of Costus spicatus flower. Oral administration of effect of ECS to diabetic induced rats at dosage of 500 mg/kg body weight resulted during significant decrease of elevated blood glucose & hepatic transaminase enzyme levels, at different treatment period (0 th day, 28 th day & 45 th day) which also showed the structural changes in cytoarchitecture of STZ induced diabetic rats.

   • According to Sivalungam MA (2019)

     Excerpt Anti-diabetic effect of plant Costus spicatus. ECS & Glibenclamide of STZ induced diabetic animals restored the normal plasma glucose levels & SGOT, SGPT & ALP levels without damaging the pancreas.

   • According to Femi-Olabisi F (2021)

     Excerpt Insulin resistance is the hall mark of PCOS as it predisposes the affected subjects to a higher risk of impaired glucose tolerance & type 2 diabetes mellitus (T2DM). In this study, the inhibitory activities of phytosterols & saccharides from aqueous extract of Costus spicatus rhizome were investigated against phosphoenol-pyruvate carboxykinase (PEPCK), α-amylase, β-glucosidase, & fructose 1,6-biphosphatase (FBPase) in silico as potential novel therapeutic targets for T2DM-associated-PCOS.

   • According to Sivalungam MA (2023)

     Excerpt The study found that Costus spicatus extract had a beneficial effect on body weight & blood glucose levels in diabetic rats. The study found that the CS leaf extract was effective in improving the antioxidant activity of important parameters such as SOD, CAT, GPx, & GR, & protected against hyperglycemia and oxidative damage in type 2 diabetes-induced hepatorenal functions both in vitro & in vivo .

   • According to Keller AC (2009)

     Excerpt More investigation is needed to more fully explore dosages & the possible utility and biological activity of this common Dominican herbal remedy for the treatment of type 2 diabetes mellitus. Insulina was identified as Costus spicatus.

3. 3

   Dermatophytosis: Epidermophyton floccosum, Trichophyton mentagrophytes, T. rubrum, Microsporum gypseum & M. canis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Silva DN (2008)

     Excerpt rubrum, Microsporum gypseum & Epidermophyton floccosum, the higher activity being against M. These results suggest, for the first time, the antifungal effectiveness of CS leaves, namely of a flavonoid-rich fraction, for dermatophytosis which are referred to as „tinea “infections.

   • According to Ali A (2022)

     Excerpt Costus spicatus (spiked spiral flag ginger) is traditionally utilised for its advantages such as antidiabetic, antihyperlipidemic, diuretic, antimicrobial, & anticancer properties. Thus, this study tested the nephroprotective effect of the polyphenol-rich extract of Costus spicatus leaves (PCSL) using preclinical models, including the HeK cell line & Wistar albino rats against cisplatin-induced toxicity.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.