Cucumis melo (Milon) : medicinal properties in alcoholic extraction

Cucumis melo (Milon, Melon) — family Cucurbitacées.

Scientific synonyms : Bryonia callosa Rottler, Cucumis melo var. microcarpus Pangalo C microcarpus (Pangalo) Pangalo, C moschatus Gray, C odoratissimus Moench, C pubescens Willd., 1805, C callosus (Rottler) Cogn. ex Engl., C chate L., Cucumis chito E.Mor., C cognata Fenzl ex Hook.f., C conomon Thunb., C deliciosus Salisb., Cs flexuosus L., C melo var. cultus Kurz, Melo sativus Vassilcz..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 23 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 103 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vidya R (2021)

     Excerpt In this present research work, the anticancer efficacy of Cucumis melo fruit extract & its silver nanoparticles was explored. The levels of serum tumor markers viz., Alpha feto protein (AFP) & Carcinoembryonic antigen (CEA) elevated in rats induced with DEN, which then were reduced following CM fruit treatment, indicating the anticancer activity of the drug.

   • According to Bouazzaoui N (2016)

     Excerpt Bouazzaoui N et al, Fatty acids & minerals composition of Melon (cucumis melo L.

   • According to Rolim PM (2018)

     Excerpt To assess the antiproliferative potential in human cancer cell lines, such as kidney carcinoma, colorectal carcinoma, cervical adenocarcinoma & cervical carcinoma, MTT assay was performed. Melon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted.

   • According to Rolim PM (2018)

     Excerpt To assess the antiproliferative potential in human cancer cell lines, such as kidney carcinoma, colorectal carcinoma, cervical adenocarcinoma & cervical carcinoma, MTT assay was performed. Melon (Cucumis melo L.) has high economic value & in recent years, its production has increased; however, part of the fruit is wasted.

   • According to Sibi P Ittiyavirah (2013)

     Excerpt Sibi P Ittiyavirah et al, Studies of Cytotoxic Potential of Cucumis melo. Linn Fruit Aqueous Extract in Prostate Cancer Cell lines PC-3 Using MTT and Neutral Red Assay, Iranian J of Pharmacol & Ther, 2013.

2. 2

   Obesity, metabolic syndrome: insulin resistance

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lee D (2018)

     Excerpt Cucumis is thus a promising treatment for obesity-induced insulin resistance & the inflammatory state. We found that Cucumis improved IR in obese mice & relieved inflammation in adipose tissu&blood.

   • According to Parmar HS (2008)

     Excerpt the peel extracts of Mangifera indica (MI), Cucumis melo (CM) & Citrullus vulgaris (CV) fruits in ameliorating the diet-induced alterations in dyslipidemia, thyroid dysfunction and diabetes mellitus have been investigated in rats. In the second experiment rats were maintained on pre-standardized atherogenic diet CCT (supplemented with 4% cholesterol, 1% cholic acid & 0.5% 2-thiouracil) to induce dyslipidemia, hypothyroidism & diabetes mellitus and the effects of the test peel extracts (200 mg/kg of MI & 100 mg/kg for CM & CV for 10 consecutive days) were studied by examining the changes in tissue LPO (in heart, liver & kidney), concentrations of serum lipids, thyroid hormones, insulin & glucose.

   • According to Srivastav A (2020)

     Excerpt C melo toluene fraction (CMTF) exhibited a significant (*P < 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). Cucumis melo possesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, & antiangiogenic activities.

   • According to Gopalasatheeskumar K (2020)

     Excerpt Antihyperglycemic & antihyperlipidemic activities of wild musk melon (Cucumis melo var. agrestis) in streptozotocin-nicotinamide induced diabetic rats.

   • According to Babulreddy N (2013)

     Excerpt Babulreddy N et al, Anti-Hyperglycemic Activity of Cucumis melo Leaf Extracts in Streptozotocin Induced Hyperglycemia in Rats, Inter J Pharm RAS, 2: 4 (2013): 22-7.

3. 3

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Srivastav A (2020)

     Excerpt C melo toluene fraction (CMTF) exhibited a significant (*P < 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). Cucumis melo possesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, & antiangiogenic activities.

   • According to Parmar HS (2008)

     Excerpt Rats, treated simultaneously with either of the peel extracts reversed the CCT-diet induced increase in the levels of tissue LPO, serum lipids, glucose, creatinine kinase-MB & decrease in the levels of thyroid hormones & insulin indicating their potential to ameliorate the diet induced alterations in serum lipids, thyroid dysfunctions & hyperglycemia/diabetes mellitus. the peel extracts of Mangifera indica (MI), Cucumis melo (CM) & Citrullus vulgaris (CV) fruits in ameliorating the diet-induced alterations in dyslipidemia, thyroid dysfunction and diabetes mellitus have been investigated in rats.

   • According to Lee D (2018)

     Excerpt Cucumis is thus a promising treatment for obesity-induced insulin resistance & the inflammatory state. This experimental study was designed to investigate the effects of Cucumis melo L.

   • According to Gopalasatheeskumar K (2020)

     Excerpt Antihyperglycemic & antihyperlipidemic activities of wild musk melon (Cucumis melo var. agrestis) in streptozotocin-nicotinamide induced diabetic rats.

   • According to Babulreddy N (2013)

     Excerpt Babulreddy N et al, Anti-Hyperglycemic Activity of Cucumis melo Leaf Extracts in Streptozotocin Induced Hyperglycemia in Rats, Inter J Pharm RAS, 2: 4 (2013): 22-7.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.