Curcuma zedoria (Zédwè) : medicinal properties in alcoholic extraction

Curcuma zedoria (Zédwè, White ginger, Zédoaire, May flower, Jenjanb-blan, Gingembre blanc, Fleur de mai) — family Zingiberacées.

Scientific synonyms : Amomum zedoaria-Christm., Curcuma pallida-Lour, C xanthorryza-Recb..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 116 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of ovarian, lung, oesophageal and liver cancer

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Zhong M (2025)

     Excerpt Curcumae Rhizoma, a traditional Chinese medicine derived from the dried rhizome of Curcuma species, has long been used to treat liver-related disorders. In the classical medical text Taiping Shenghui Fang, it was recorded for the treatment of hepatocellular carcinoma (HCC) characterized by Qi stagnation & blood stasis.

   • According to Ekowati Heny (2013)

     Excerpt Measurements of parameters based on liver histopathology and the parameters of serum alanine amino transferase (ALT) & aspartate amino transferase (AST). Curcuma Xanthorrhiza, Curcuma longa & Zingiber officinale are commonly used as herbals in Indonesia and around the world.

   • According to Soni KB (1992)

     Excerpt Soni KB et al, Reversal of aflatoxin induced liver damage by turmeric & curcumin.

   • According to DEVARAJ S (2010)

     Excerpt The results of the present study indicated that CX possess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases. The hepatoprotective activity of this extract was studied using ethanol- induced liver toxicity in rats.

   • According to Yasni S (n.d.)

     Excerpt Addition of essential oils (0.02%), prepared by steam distillation, to a purified diet resulted in a lower hepatic triglyceride concentration without influencing the serum triglyceride, whereas addition of the hexane-soluble fraction (0.5%) resulted in a lower concentration of serum as well as liver triglycerides. Rats fed the EO & hexane-soluble fraction had lower hepatic fatty acid synthase activity.

2. 2

   Type II diabetes mellitus

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to ALIPIN K (2019)

     Excerpt Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels or hyperglycemia due to deficiency or ineffectiveness of insulin. This study aims to determine the effectiveness & optimum dosage combination CX rhizomes & AB fruit extract as anti-diabetic herbs in decreasing blood glucose levels, improve pancreas histopathology & the liver structure repair of diabetic male Wistar rats induced by streptozotocin.

   • According to Rahmatullah M (2012)

     Excerpt The objective of the present research was to evaluate in oral glucose tolerance tests, the anti-hyperglycemic potential of methanol extract of Curcuma zedoaria rhizomes & fruits of Sonneratia caseolaris, both of which are used as anti-diabetics in the folk medicinal system of Bangladesh. The demonstrated anti-hyperglycemic activities by rhizomes of CZ & fruits of S validate their folk medicinal uses & warrants further studies towards elucidation of responsible phytochemical components, which can be potentially more efficacious drugs for treatment of diabetes.

   • According to Prasetyawan S (2023)

     Excerpt Type 2 diabetes mellitus (T2DM) is a metabolic disease with a high risk of complications & mortality.

   • According to Handjani J (2015)

     Excerpt Streptozotocin (STZ) (Naclai tesque, Kyoto Japan) with a dose of 40 mg/kg was used to create hyperglycemia condition in those rats. The control group was consisted often rats, divided into two subgroups, as the positive control group (induced with 10 mg/kg of Glibenclamide) & the negative control group (induced with propylene glycol).

   • According to Rahmat E (2021)

     Excerpt To date, over 40 active compounds, including terpenoids, curcuminoids, & other phenolic compounds, have been isolated & identified from C.X Some pharmacological tests reported that CX has antioxidant, antimicrobial, anti-inflammatory, anticancer & antitumor, antidiabetic, & skincare & hepatoprotective properties. Curcuma xanthorrhiza Roxb., locally famed as Temulawak, has been extensively utilized in Indonesia as medicinal & nutritional plants since immemorial time.

3. 3

   Prevention of liver damage caused by doxorubicin

   Plant part used: Rhizome. Mentioned synergistic association: Curcuma longa, association synergique avec ZINGIBER OFFICINALE-Roscoe (Rhizome).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ekowati Heny (2013)

     Excerpt officinale has a protective effect in rats against liver damage induced by doxorubicin. Curcuma Xanthorrhiza, Curcuma longa & Zingiber officinale are commonly used as herbals in Indonesia and around the world.

   • According to Zhong M (2025)

     Excerpt Curcumae Rhizoma, a traditional Chinese medicine derived from the dried rhizome of Curcuma species, has long been used to treat liver-related disorders. In the classical medical text Taiping Shenghui Fang, it was recorded for the treatment of hepatocellular carcinoma (HCC) characterized by Qi stagnation & blood stasis.

   • According to DEVARAJ S (2010)

     Excerpt The results of the present study indicated that CX possess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases. The hepatoprotective activity of this extract was studied using ethanol- induced liver toxicity in rats.

   • According to Yasni S (n.d.)

     Excerpt Addition of essential oils (0.02%), prepared by steam distillation, to a purified diet resulted in a lower hepatic triglyceride concentration without influencing the serum triglyceride, whereas addition of the hexane-soluble fraction (0.5%) resulted in a lower concentration of serum as well as liver triglycerides. Rats fed the EO & hexane-soluble fraction had lower hepatic fatty acid synthase activity.

   • According to Yasni S (1991)

     Excerpt xanthorrhiza decreased the concentrations of serum triglycerides and phospholipids, and liver cholesterol, and increased serum HDL-cholesterol and apo A-I. xanthorrhiza on serum & liver lipids, serum high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo) A-I, & liver lipogenic enzymes in rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.