Cyperus rotundus (Koko-cat) : medicinal properties in alcoholic extraction

Cyperus rotundus (Koko-cat, Ti-Vensan, Chien-Kôk, Coco-à-chat, Little Vincent, Chien-coq, Koko-chat, Petit Vincent) — family Cypéracées.

Scientific synonyms : Cyperus purpurea variegatus-Böcklr. C hexastachyus-Roxb. C hydra-Michx..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 33 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 118 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of oral, colorectal and liver cancer

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xue BX (2023)

     Excerpt Their pharmacological effects on the digestive system, nervous system, gynecological diseases, & other bioactivities like antioxidant, anti-inflammatory, anti-cancer, insect repellent, anti-microbial activity, etc. In traditional Chinese medicine (TCM), its rhizomes are frequently used to treat liver disease, stomach pain, breast tenderness, dysmenorrheal & menstrual irregularities.

   • According to Gurusamy K (2010)

     Excerpt The ethanolic extracts of the polyherbal medicinal plants (Asteracantha longifolia, Cyperus rotundus & Bryophyllum pinnatum) were evaluated for hepatoprotective activity in carbon tetrachloride induced liver damage in rats. exhibited a significant protective effect by lowering serum and liver activities of aspartate transaminase (AST), alanine transaminase (ALT), acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum Bilirubin, serum cholesterol & serum total protein when compared with standard silymarin.

   • According to DHANYA NV (2017)

     Excerpt The present study was carried out to investigate the in vitro anticancer potential of ethanol extract of the rhizome of Cyperus rotundus in KB oral cancer cell lines. All these results establish the effect of CR as a potent anticancer agent against oral cancer cell lines.

   • According to Nidugala H (2016)

     Excerpt This study was designed to investigate the in vitro anticancer potential of aqueous & ethanol extracts of Cyperus rotundus (L.). Nidugala H et al, in vitro cytotoxic activity of rhizome extracts of Cyperus rotundus (L.) against colon Carcinoma and Ehrlich ascites Carcinoma.

   • According to Suryawanshi S (2019)

     Excerpt Aim of the study: The present study is aimed at evaluating the anticancer activity of the polyherbal formulation (HC9) & its mechanism of action against breast cancer cell lines. Cyperus rotundus L., Zingiber officinale Roscoe, Cedrus deodara (Roxb.

2. 2

   Type II diabetes mellitus

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Raut Na (2012)

     Excerpt Traditional systems of medicine reported the use of Cyperus rotundus in the treatment of diabetes. These fractions were screened for antidiabetic activity using alloxan induced diabetes in rats.

   • According to Raut NA (2006)

     Excerpt In light of the traditional claim of C rotundus in the treatment of diabetes, investigations were carried out to evaluate its effect on alloxan induced hyperglycemia in rats.

   • According to Kabbashi AS (2015)

     Excerpt rotundus whole plant ethanol extract which exhibited 100% mortality within 96 h, at a concentration 500 ppm; this was compared with Metronidazole which gave 96% inhibition at concentration 312.5 µg/ml at the same time In addition cytotoxicity (MTT assay) with different concentration (500, 250 & 125 ppm) in comparison to triton-x100 (the reference control) which verified the safety of the examined extract with an IC50 less 100 µg/ml. (Family: Cyperaceae), has a number of pharmacological and biological activities including anti-inflammatory, antidiabetic, antidiarrhoeal, cytoprotective, antimutagenic, antimicrobial, antioxidant, cytotoxic and apoptotic, anti-pyretic & analgesic activities.

   • According to Nagaraj Kanagali S (2021)

     Excerpt The present study aimed to evaluate the interaction of reported bioactives from Cyperus rotundus against obesity via network pharmacology & to evaluate the efficacy of hydroalcoholic extract of CR against the olanzapine-induced weight gain & metabolic disturbances in experimental animals. During treatment, body weight & food intake were recorded; after the successful completion of 21 days of treatment, animals were fasted to perform oral glucose & insulin tolerance tests.

3. 3

   Hepatitis B, cirrhosis, fatty liver disease

   Plant part used: Rhizome.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xue BX (2023)

     Excerpt In traditional Chinese medicine (TCM), its rhizomes are frequently used to treat liver disease, stomach pain, breast tenderness, dysmenorrheal & menstrual irregularities.

   • According to Gurusamy K (2010)

     Excerpt The ethanolic extracts of the polyherbal medicinal plants (Asteracantha longifolia, Cyperus rotundus & Bryophyllum pinnatum) were evaluated for hepatoprotective activity in carbon tetrachloride induced liver damage in rats. exhibited a significant protective effect by lowering serum and liver activities of aspartate transaminase (AST), alanine transaminase (ALT), acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum Bilirubin, serum cholesterol & serum total protein when compared with standard silymarin.

   • According to AL-MASSARANI SHAZA (2016)

     Excerpt AL-MASSARANI SHAZA et al, Composition & biological activity of Cyperus rotundus L tuber volatiles from Saudi Arabia, Natural Volatiles & Essential Oils, 3’2) :2016.Abstract The present study was conducted to investigate the composition of the oïl of Cyperus rotundus L. The essential oïl recovered with diethyl ether demonstrated potent cytotoxic activities against colon (HCT-116), hepatocellular (Hep G-2) & breast (MCF-7) human cancer cell lines with IC50s of 1.06, 1.17 & 2.22 µg/mL, respectively.

   • According to Oladunni OM (2011)

     Excerpt The present study was undertaken to investigate the physicochemical properties of the oil, mineral & nutritional compositions of Cyperus rotundus (nut of nut grass).

   • According to Babiaka SB (2021)

     Excerpt Since 1965, a total of about 192 compounds including terpenoids, flavonoids, stilbenes, aromatics & aliphatic fatty acids have been characterized. (Nutgrass, family Cyperaceae) is a notorious weed which is widespread in temperate tropical & subtropical regions of the world.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.