Cytrus hystrix (Kaffir lime) : medicinal properties in alcoholic extraction

Cytrus hystrix (Kaffir lime, Combava) — family Rutacées.

Scientific synonyms : Citrus micranta-W, Fortunella sagittifolia-F & M.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 118 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Doxorubicin-induced liver and heart disease

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pallavi M (2021)

     Excerpt Remarkably, lime peel extract followed by sour orange & orange at 500 mg kg-1 dose improved hepatic architecture to near normal with less deposition of fat globules & fewer sinusoids.

   • According to Arumugam A (2015)

     Excerpt On the 7th day animals were sacrificed & liver function markers (ALT, AST, ALP), total bilirubin & total protein in blood serums & hepatic antioxidants (SOD, CAT, GSH & GPx) in liver homogenate were estimated. The leaf extracts restored the liver function markers & hepatic antioxidants to the normal level than elevated levels noticed on paracetamol control at p < 0.001.

   • According to Putri H (2013)

     Excerpt ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity & hepatotoxicity rats, but did not repair neither hepatohisto-pathology profile nor reduce serum activity of ALT & AST. To observe the combination effect of doxorubicin & Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) & aspartate aminotransferase (AST) activity & cardio-hepato-histopathology of female Sprague Dawley rats.

   • According to Ishak M (2020)

     Excerpt This study aims to investigate the efficacy of Citrus hystrix leaf extract (CLE) in alleviating CAC.

   • According to Dertyasasa (2017)

     Excerpt : Previous studies have reported that a number of organic compounds are present in kaffir lime (Citrus hystrix DC.) leaf extracts.

2. 2

   Bacterial infection: Escherichia coli, Staphylococcus aureus, Salmonella Typhimurium, Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Arumugam A (2012)

     Excerpt The microorganisms used include Staphylococcus aureus (MTCC 3160), Salmonella typhi (MTCC 3215), Escherichia coli (MTCC 40), Pseudomonas aeruginosa (MTCC 424), Klebsiella pneumoniae (MTCC 3384). Since plants are used as therapeutic agents, the present study was conducted to evaluate the antibacterial activities of methanolic extracts of different components of Citrus hystrix & Citrus maxima ( Red & White) fruit.

   • According to Nendissa SJ (2021)

     Excerpt To support its use and increase its application in supporting food safety, a test the inhibition of on kaffir lime leaf extract against pathogenic bacteria, namely Gram Negative Bacteria (Escherichia coli, Salmonella typhimurium ) & Gram Positive bacteria ( Staphylococcus aereus, P. The antibacterial activity of CH leaf extract was tested by diffusion method using disc paper to determine of the bacterial growth inhibition area.

   • According to Srisukh Vimol (2012)

     Excerpt The antibacterial activities were tested by disc-diffusion & broth microdilution methods against 411 isolates of groups A, B, C, F, G streptococci, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus (methicillin-resistant & -sensitive S. Citrus hystrix DC, or makrut lime, contains two essential oils, makrut leaf oil & makrut (fruit peel) oil, of which we determined the inhibitory effect against respiratory pathogens & evaluated their active components.

   • According to Othman (2016)

     Excerpt hystrix essential oil has been experimentally shown to have antimicrobial & antifeedant activities, while no bioactivity study has been reported on the essential oils of other Malaysian Citrus species.

   • According to DOREEN SH (2011)

     Excerpt A study was conducted to evaluate the antibacterial activities of the emulsions containing essential oil of Kaffir lime, Citrus hystrix. Emulsion with surfactant mixture of Tween 80 & Span 80 at the ratio of 90:10 with 2% essential oil had the most effective antibacterial properties.

3. 3

   Colitis associated with colorectal carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ishak M (2020)

     Excerpt Patients with IBD are associated with high risk of colorectal cancer (CRC), namely, colitis associated cancer (CAC). Thus, CLE effect on colitis associated cancer was further investigated in an animal model to see how the body respond to CLE absorption in the body of mice.

   • According to Abelmaesoomi M (2022)

     Excerpt In this study, the antioxidant activities of hexane, ethyl acetate, methanol & water extracts of CH leaves & their growth inhibitory effects on colorectal (HCT 116) & breast cancer (MCF 7, MDA-MB 231 & HCC 1937) cells were analysed. However, information on breast & colorectal cancer is limited especially the mechanistic aspects.

   • According to Wijayanti N (2015)

     Excerpt The objective of this research was to determine the cytotoxicity effect & apoptosis induced by leaves extract CH to cervical cancer cell line (HeLa cells). Leaves of CH contain of polyphenols & essential oils thus they were possibly cytotoxic to cancer cell line.

   • According to Ho Y (2020)

     Excerpt This study aimed to evaluate the anticancer properties of CH leaf extract & its bioactive constituents citronellol & citronellal against the triple negative breast cancer MDA-MB-231 cell line. The in vitro anticancer effects of CH leaf extracts, & its bioactive constituents (citronellol & citronellal) were evaluated against MDA-MB-231 cell line using cytotoxic MTT assay, cell proliferation, wound scratch migration, colony formation, cell cycle, apoptosis assay, Hoechst staining, RT-qPCR, & Western blot analysis.

   • According to Tunjung WAS (2015)

     Excerpt These data showed that CH extract reduces the viability of cervical & neuroblastoma cell lines & may have potential as anti-cancer compounds. The objective of this study was to examine the cytotoxic effect of CH leaf extract on cervical cancer & neuroblastoma cell lines.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.