Datura innoxia (Gwo-Konkonb-chien) : medicinal properties in alcoholic extraction

Datura innoxia (Gwo-Konkonb-chien, Gwo-konkonb- djab, Large dog-cucumber, Large devil-cucumber, Trumpet of Judgement, Gros-concombre-à-chien, Gros-concombre-à-diable, Trompette du Jugement) — family Solanacées.

Scientific synonyms : Brugmansia waymanni-Paxton, Datura humilis-dest, D metel-L, D meteloides-DC ex Dunal, D Wagmanii-Steud.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 42 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Escherichia coli, Bacillus anthracoides

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kaushik P (2008)

     Excerpt Various parts of Datura innoxia were examined for potential antibacterial activity by preparing their crude aqueous & organic extracts against Gram-negative bacteria (Escherichia coli & Salmonella typhi) & Gram-positive bacteria (Bacillus cereus, Bacillus subtilis & Staphylococcus aureus). The study promises an interesting future for designing a potentially active antibacterial agent from Datura innoxia.

   • According to Effekthar F (2005)

     Excerpt The antibacterial activity of the methanol extracts of the aerial parts of the Datura innoxia & Datura stramonium was investigated. Little or no antibacterial activity was found against Escherichia coli & Pseudomonas aeruginosa.

   • According to Garaev EA (2021)

     Excerpt The antimicrobial activity of plant oils of seed & ethanolic extracts of some parts (roots, stems, leaves, flowers, fruits & seeds) were studied on Staphylococcus aureus, Esherichia coli, Pseudomonas aeruginosa, Bacillus anthracoides, Klebsiella pneumoniae & Candida albicans. The purpose of the investigation is to study non-alkaloidal biological active compounds of various organs, the antimicrobial activity of plant oil & ethanolic extracts of Datura innoxia from nightshades (Solanaceae).

   • According to Shama AI (2014)

     Excerpt The aim of this study was evaluated the Antimicrobial Activity of extraction of Datura innoxia (Seeds, leaves & roots). Extracts of methanol, & aqueous of seeds, leaves & roots were prepared & tested against four types of bacteria namely: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa & Proteus vulgaris & two types of fungi namely: Aspergillus niger & Candida albicans.

   • According to Tandon P (2016)

     Excerpt The ethanol, hexane & aqueous leaf extracts of Datura inoxia were screened for their antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa & Escherichia coli. All extracts showed inhibitory effect against Staphylococcus aureus & Escherichia coli, while no inhibitory effect was found by aqueous & hexane extracts against Pseudomonas aeruginosa.

2. 2

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Vermillion K (2011)

     Excerpt Extracts and the purified compound were tested for their antiproliferative activities toward a panel of human normal & cancer cell lines. A new withanolide, Dinoxin B (12,21-dihydroxy-1-oxowitha-2,5,24-trienolide-27-O-β-d-glucopyranoside, 1), was isolated from a methanol extract of Datura inoxia leaves, using Bioassay-guided fractionation.

   • According to Cheshomi H (2016)

     Excerpt The present study was conducted to evaluate the cytotoxic effects of the methanolic extracts of Datura innoxia petals, native to central & South America & distributed in Africa, Asia, Australia, & Europe, on the breast cancer cell line (MCF-7). Conclusions: These findings indicate that the methanolic extracts of DI petals can act as a possible food supplement with anticancer effects & can be used after complementary tests,.

   • According to Al-Zharani (2021)

     Excerpt The cell viability study revealed that the ethanolic extract of DI demonstrated potent cytotoxicity, with a 50-IC value of 10 μg/mL against LoVo colon cancer cells. innoxia on various cancer cell proliferation.

   • According to Arul Vasu C (2010)

     Excerpt In the present study, we investigated the effects of methanolic leaf extracts from Datura innoxia, on the growth of human colon adenocarcinoma (HCT 15) & human larynx cancer cell lines (Hep-2). These herbal preparations alleged to have many biological activities, such as stimulation or suppression of immune responses & antiproliferative effects on cancer cells.

   • According to BABU G (2019)

     Excerpt Thus, this study reveals that the green synthesis is an ecofriendly method for production of AgNPs from Datura inoxia flower extract which provided a powerful anti-proliferative action on MCF7 cell line, suggesting them as a novel chemotherapeutic agent against human breast cancer. The silver nanoparticles (AgNPs) were synthesized biologically through a green synthesis method using the flower extract of Datura inoxia, a well-known medicinal plant for its antispasmodic, pacifying, pain relief, and for respiratory ailments.

3. 3

   Infection: bacterial: Staphylococcus aureus, methicillin-resistant

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kaushik P (2008)

     Excerpt Various parts of Datura innoxia were examined for potential antibacterial activity by preparing their crude aqueous & organic extracts against Gram-negative bacteria (Escherichia coli & Salmonella typhi) & Gram-positive bacteria (Bacillus cereus, Bacillus subtilis & Staphylococcus aureus). The study promises an interesting future for designing a potentially active antibacterial agent from Datura innoxia.

   • According to Effekthar F (2005)

     Excerpt The antibacterial activity of the methanol extracts of the aerial parts of the Datura innoxia & Datura stramonium was investigated. Little or no antibacterial activity was found against Escherichia coli & Pseudomonas aeruginosa.

   • According to George R (2021)

     Excerpt Conclusion: Dinoxin B with its bactericidal properties & significant affinity towards Quorum-signaling Sar A protein & Penicillin Binding Protein can be considered as an effective bioactive compound against Methicillin Resistance Staphylococcus aureus. Objective: This research has focused to evaluate the efficacy of Dinoxin B Withanolide against infectious Staphylococcus aureus, including resistant strains.

   • According to Garaev EA (2021)

     Excerpt The antimicrobial activity of plant oils of seed & ethanolic extracts of some parts (roots, stems, leaves, flowers, fruits & seeds) were studied on Staphylococcus aureus, Esherichia coli, Pseudomonas aeruginosa, Bacillus anthracoides, Klebsiella pneumoniae & Candida albicans. The purpose of the investigation is to study non-alkaloidal biological active compounds of various organs, the antimicrobial activity of plant oil & ethanolic extracts of Datura innoxia from nightshades (Solanaceae).

   • According to Shama AI (2014)

     Excerpt The aim of this study was evaluated the Antimicrobial Activity of extraction of Datura innoxia (Seeds, leaves & roots). Extracts of methanol, & aqueous of seeds, leaves & roots were prepared & tested against four types of bacteria namely: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa & Proteus vulgaris & two types of fungi namely: Aspergillus niger & Candida albicans.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.