Datura metel (Karapat bata) : medicinal properties in alcoholic extraction

Datura metel (Karapat bata, Gwo konkonb-chien, Carapate-batard, Gros concombre-à-chien, Trumpet of Judgement, Trompette du Jugement) — family Solanacées.

Scientific synonyms : Datura fastuosa sensu Griseb non L Duss.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 158 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: group B haemolytic Streptococcus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus and Streptococcus dysenteriae

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2011)

     Excerpt The antibacterial efficacy of crude aqueous and ethanol extracts leaf, stem bark and roots of Datura metel at 20mg/ml were assayed against eight clinical bacterial isolates (Streptococcus b hemolytic, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus & Streptococcus dysenteriae) by well in agar method The leaf & stem bark of the plant was antagonistic against the test bacteria species with inhibitory zones of between 35-12 mm while the highest inhibitory zone displayed by one of the reference drug (streptomycin) was 45 mm at 10mg/ml concentration. Among the tested bacterial isolates S aureus was the most inhibited majorly with the ethanol extract.

   • According to Alabri THA (2014)

     Excerpt The MTOH crude extract & its derived fractions from dry & fresh leaves showed small & moderate antibacterial potential with one-gram positive (Staphylococcus aureus) & three-gram negative (Escherichia coli, Klebsiella pneumoniae & Pseudomonas aeruginosa) bacteria in the range of 0–17%. The aim of this work is to investigate & compare the phytochemical screening, antioxidant & antimicrobial activities of different crude extracts from dry & fresh leaves of Datura metel L.

   • According to Okwu DE (2009)

     Excerpt Compound 1 displayed antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabis, Solmonella typhi, Bacillus subtilis & Klebsiella pneumonia but could not inhibit Escherichia coli. A new antibacterial agent 5, 7 dimethyl 6– hydroxy 3, phenyl 3 α amine β yne sitosterol 1 has been isolated from Datura metel leaves.

   • According to BAWAZEER S (2021)

     Excerpt Among the extract & various fractions, the chloroform fraction exhibited a significant effect against different bacterial strains including Escherichia coli, Staphylococcus aureus, & Bacillus subtilis with an inhibitory zone ranging from 18 to 24 mm. Daturaolone exhibited potent activity against selected bacterial strains including Klebsiella pneumoniae, B.

   • According to KUMARI K (2020)

     Excerpt The aim of this work is to investigate antimicrobial activities of different crude extracts from dry & fresh leaves of Datura metel. Datura metel, is native of southern China is commonly called horn of plenty, devil’s trumpet, angel’s trumpet or thornapple.

2. 2

   Autoimmune disease: inflammatory skin condition

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to LI T (2019)

     Excerpt Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia & excessive infiltration of inflammatory cells. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia & inflammatory cell infiltration in the effective skin of model mice.

   • According to Neeraj O.M (2013)

     Excerpt Datura has a very special place in Ayurveda since all parts of the plant namely leaves, flowers, seeds, roots, have been used for a wide range of medication such as treatment of leprosy, rabies, insanity, etc. Recently, withanolide compounds have shown significant antitumor, cytotoxic, anti-inflammatory, antibacterial, hepatoprotective, sedative, cytostatic & immunosuppressive activity.

   • According to Mai NT (2017)

     Excerpt Chemical investigation of an acidic methanol extract of the whole plants of Datura metel resulted in the isolation of two new guainane sesquiterpenes, 1β,5α,7β-guaiane-4β,10α,11-triol (1) & 1α,5α,7α-11-guaiene-2α,3β,4α,10α,13-pentaol (2), along with eight known compounds: pterodontriol B (3), disciferitriol (4), scopolamine (5), kaempferol 3-O-β-D-glucosyl(1 → 2)-β-D-galactoside 7-O-β-D-glucoside (6), kaempferol 3-O-β-glucopyranosyl(1 → 2)-β-glucopyranoside-7-O-α-rhamnopyranoside (7), pinoresinol 4′′-O-β-D-glucopyranoside (8), (7R,8S,7′S,8′R)-4,9,4′,7′-tetrahydroxy-3,3′-dimethoxy-7,9′-epoxy-lignan-4-O-β-D-glucopyranoside (9), & (7S,8R,7′S,8′S)-4,9,4′,7′-tetrahydroxy-3,3′-dimethoxy-7,9′-epoxylignan-4-O-β-D-glucopyranoside (10). Compounds 2-4 & 6-10 were shown to have modest anti-inflammatory effects through inhibition of NO production in LPS-stimulated BV cells.

   • According to TAN JY (2020)

     Excerpt The anti-inflammatory effect of daturmetesides A-E was all tested by measuring nitric oxide production in lipopolysaccharide-activated RAW264.7 cells. Five undescribed ergostane-type C28 sterols, daturmetesides A-E (1-5), were isolated from the leaves of Datura metel L.

   • According to Khaton MM (2012)

     Excerpt Datura metel is well known for its insecticidal, herbicidal, anti-fungal, anti-bacterial, anti-cancer, anti-inflammatory & anti-rheumatoid activity. The present paper summarizes the phyto-chemistry, traditional uses & pharmacological actions of the plant Datura metel.

3. 3

   Oxidative stress

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to VINCENT-JUNIOR I (n.d.)

     Excerpt In this study, we evaluated the hypothesis that oral exposure to DM extract exerts a neurotoxic effect by increasing oxidative stress in the mPFC & the hippocampus & induces behavioral deficits in mice. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psycho-stimulatory properties.

   • According to IGBEN VO (2023)

     Excerpt In this study, we evaluated the hypothesis that oral exposure to DM extract exerts a neurotoxic effect by increasing oxidative stress in the mPFC & the hippocampus & induces behavioral deficits in mice. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties.

   • According to OBOMA YI (2025)

     Excerpt Extracts cause cortex & hippocampus neurotoxicity through heightened oxidative stress. Datura metel is reported to induce hallucinations & mental disorders.

   • According to Mbida H (2022)

     Excerpt Survival time & some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves & seeds of Datura metel. The aim of this work was to evaluate the antioxidant potential of Datura metel.

   • According to FU Y (n.d.)

     Excerpt Orthogonal signal correction-partial least squares-discriminant analysis (OSC-PLS-DA) of NMR profiles supplemented with correlation network analysis revealed significant altered metabolites & related pathway that contributed to oxidative stress, energy metabolism disturbances, neurotransmitter imbalance & amino acid metabolism disorders. metel once a day at doses for 10 mg/kg & 40 mg/kg for consecutive 4 days, 1H NMR based metabolomics approach aided with histo-pathological inspection & biochemical assays were used for the first time to study the psycho-active & toxic effects of DM..

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.