Datura metel (Karapat bata) : vertus médicinales en extraction alcoolique

Datura metel (Karapat bata, Gwo konkonb-chien, Carapate-batard, Gros concombre-à-chien, Trompette du Jugement, Trumpet of Judgement) — famille Solanacées.

Synonymes scientifiques : Datura fastuosa sensu Griseb non L Duss.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 4 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 158 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Infection bacterienne : Streptococcus b - hemolytic, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus & Streptococcus dysenteriae

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Auteur (2011)

     Extrait The antibacterial efficacy of crude aqueous and ethanol extracts leaf, stem bark and roots of Datura metel at 20mg/ml were assayed against eight clinical bacterial isolates (Streptococcus b hemolytic, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus & Streptococcus dysenteriae) by well in agar method The leaf & stem bark of the plant was antagonistic against the test bacteria species with inhibitory zones of between 35-12 mm while the highest inhibitory zone displayed by one of the reference drug (streptomycin) was 45 mm at 10mg/ml concentration. Among the tested bacterial isolates S aureus was the most inhibited majorly with the ethanol extract.

   • Selon Alabri THA (2014)

     Extrait The MTOH crude extract & its derived fractions from dry & fresh leaves showed small & moderate antibacterial potential with one-gram positive (Staphylococcus aureus) & three-gram negative (Escherichia coli, Klebsiella pneumoniae & Pseudomonas aeruginosa) bacteria in the range of 0–17%. The aim of this work is to investigate & compare the phytochemical screening, antioxidant & antimicrobial activities of different crude extracts from dry & fresh leaves of Datura metel L.

   • Selon Okwu DE (2009)

     Extrait Compound 1 displayed antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabis, Solmonella typhi, Bacillus subtilis & Klebsiella pneumonia but could not inhibit Escherichia coli. A new antibacterial agent 5, 7 dimethyl 6– hydroxy 3, phenyl 3 α amine β yne sitosterol 1 has been isolated from Datura metel leaves.

   • Selon BAWAZEER S (2021)

     Extrait Among the extract & various fractions, the chloroform fraction exhibited a significant effect against different bacterial strains including Escherichia coli, Staphylococcus aureus, & Bacillus subtilis with an inhibitory zone ranging from 18 to 24 mm. Daturaolone exhibited potent activity against selected bacterial strains including Klebsiella pneumoniae, B.

   • Selon KUMARI K (2020)

     Extrait The aim of this work is to investigate antimicrobial activities of different crude extracts from dry & fresh leaves of Datura metel. Datura metel, is native of southern China is commonly called horn of plenty, devil’s trumpet, angel’s trumpet or thornapple.

2. 2

   Maladie auto-immune : dermatose inflammatoire

   Partie usitée : Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon LI T (2019)

     Extrait Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia & excessive infiltration of inflammatory cells. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia & inflammatory cell infiltration in the effective skin of model mice.

   • Selon Neeraj O.M (2013)

     Extrait Datura has a very special place in Ayurveda since all parts of the plant namely leaves, flowers, seeds, roots, have been used for a wide range of medication such as treatment of leprosy, rabies, insanity, etc. Recently, withanolide compounds have shown significant antitumor, cytotoxic, anti-inflammatory, antibacterial, hepatoprotective, sedative, cytostatic & immunosuppressive activity.

   • Selon Mai NT (2017)

     Extrait Chemical investigation of an acidic methanol extract of the whole plants of Datura metel resulted in the isolation of two new guainane sesquiterpenes, 1β,5α,7β-guaiane-4β,10α,11-triol (1) & 1α,5α,7α-11-guaiene-2α,3β,4α,10α,13-pentaol (2), along with eight known compounds: pterodontriol B (3), disciferitriol (4), scopolamine (5), kaempferol 3-O-β-D-glucosyl(1 → 2)-β-D-galactoside 7-O-β-D-glucoside (6), kaempferol 3-O-β-glucopyranosyl(1 → 2)-β-glucopyranoside-7-O-α-rhamnopyranoside (7), pinoresinol 4′′-O-β-D-glucopyranoside (8), (7R,8S,7′S,8′R)-4,9,4′,7′-tetrahydroxy-3,3′-dimethoxy-7,9′-epoxy-lignan-4-O-β-D-glucopyranoside (9), & (7S,8R,7′S,8′S)-4,9,4′,7′-tetrahydroxy-3,3′-dimethoxy-7,9′-epoxylignan-4-O-β-D-glucopyranoside (10). Compounds 2-4 & 6-10 were shown to have modest anti-inflammatory effects through inhibition of NO production in LPS-stimulated BV cells.

   • Selon TAN JY (2020)

     Extrait The anti-inflammatory effect of daturmetesides A-E was all tested by measuring nitric oxide production in lipopolysaccharide-activated RAW264.7 cells. Five undescribed ergostane-type C28 sterols, daturmetesides A-E (1-5), were isolated from the leaves of Datura metel L.

   • Selon Khaton MM (2012)

     Extrait Datura metel is well known for its insecticidal, herbicidal, anti-fungal, anti-bacterial, anti-cancer, anti-inflammatory & anti-rheumatoid activity. The present paper summarizes the phyto-chemistry, traditional uses & pharmacological actions of the plant Datura metel.

3. 3

   Stress oxydatif

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon VINCENT-JUNIOR I (s.d.)

     Extrait In this study, we evaluated the hypothesis that oral exposure to DM extract exerts a neurotoxic effect by increasing oxidative stress in the mPFC & the hippocampus & induces behavioral deficits in mice. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psycho-stimulatory properties.

   • Selon IGBEN VO (2023)

     Extrait In this study, we evaluated the hypothesis that oral exposure to DM extract exerts a neurotoxic effect by increasing oxidative stress in the mPFC & the hippocampus & induces behavioral deficits in mice. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties.

   • Selon OBOMA YI (2025)

     Extrait Extracts cause cortex & hippocampus neurotoxicity through heightened oxidative stress. Datura metel is reported to induce hallucinations & mental disorders.

   • Selon Mbida H (2022)

     Extrait Survival time & some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves & seeds of Datura metel. The aim of this work was to evaluate the antioxidant potential of Datura metel.

   • Selon FU Y (s.d.)

     Extrait Orthogonal signal correction-partial least squares-discriminant analysis (OSC-PLS-DA) of NMR profiles supplemented with correlation network analysis revealed significant altered metabolites & related pathway that contributed to oxidative stress, energy metabolism disturbances, neurotransmitter imbalance & amino acid metabolism disorders. metel once a day at doses for 10 mg/kg & 40 mg/kg for consecutive 4 days, 1H NMR based metabolomics approach aided with histo-pathological inspection & biochemical assays were used for the first time to study the psycho-active & toxic effects of DM..

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.