Datura stramonium (Konkond-djab) : medicinal properties in alcoholic extraction

Datura stramonium (Konkond-djab, Konkonb-chien, Konkonb-zonbi, Devil’s Cucumber, Dog-cucumber, Zombie-cucumber, Concombre-à-diable, Concombre-à-Chien, Concombre-à-Zombi) — family Solanacées.

Scientific synonyms : Datura capensis-Benth, D laevis-L. f, D micropcarpa-Godtr, D Parviflora-Salisb, D tatula-L, Stramonium foetidum-S, S spinosum Lam., S vulgare Moench, S vulgatum Gaertn..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 126 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Adjuvant treatment for liver and breast cancer

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Iqbal S (2017)

     Excerpt Datura stramonium belongs to the family Solanaceae which is commonly dubbed as thorn apple or jimson weed, & is abundant throughout tropical & subtropical regions. in vitro cytotoxic activity for MCF7 (breast cancer) cell line was too studied by MTT reagent assay method.

   • According to Gupta A (2016)

     Excerpt The immunomodulatory potential of DS active fraction was assessed by i) MTT microcytotoxicity assay using A549 (lung carcinomas) & MCF-7 (breast cancer) cell lines & ii) analyzing the production of IL-2 and IFN-γ by human PBMC in the presence of active fraction. stramonium leaves on human peripheral blood mononuclear cells (PBMC) followed by assessment of cytotoxic abilities of immunomodulated PBMC toward cancer cells.

   • According to Alum EU (2023)

     Excerpt Thus, we investigated the effect of Datura stramonium ethanolic leaf extract (DSELE) supplementation in MXT-induced biochemical alterations in rats. Key findings MTX caused a significant (P<0.05) increase in serum activities of liver enzymes (AST, ALT & ALP) & levels of total cholesterol & low-density lipoprotein while the levels of total protein & albumin decreased significantly relative to the normal control.

   • According to Nasir B (2020)

     Excerpt Datura stramonium (DS) & Datura inoxia (DI) are the two species chosen for this study.-Methods: total phenolic and flavonoid content (TPC & TFC) as well as antioxidant activity were assessed through colorimetric method. Leukemia induced in rats was affirmed by elevated serum levels of WBCs (7.78 ± 0.012 (× 103) /μl), bilirubin (7.56 ± 0.97 mg/dl), Thiobarbituric acid reactive substances (TBARs) (133.75 ± 2.61 nM/min/mg protein), decreased RBCs (4.33 ± 0.065 (× 106)/μl), platelets (344 ± 3.19 (× 103)/μl), total proteins (2.14 ± 0.11 g/dl), Glutathione S-transferases (GST) (81.01 ± 0.44 nM/min/ml), endogenous antioxidant enzymes levels & abnormal liver and kidney functionality in disease control rats.

   • According to Togola I (2023)

     Excerpt The results of that study showed that three Datura species investigated have immunostimulant potential which could them to be useful in the treatment of breast & cervical cancers. The anti-inflammatory potential was estimated using cancer cells, by quantifying nitrites (NO) based on colorimetric method (Griess reaction) & the cell viability based on the WST-1 assay.

2. 2

   Diarrhoea

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2013)

     Excerpt Three experiments were performed, Exp-1 & Exp-2 were designed to study the antidiarrhoeal effect & the effect on enteropooling induced by castor oil for two treated groups (T1&T2) orally dosed with Datura stramonium leaves hydroethanolic extract at 50 &100mg/Kg BW. Exp-1 results showed that both DS extract doses caused a dose dependent antidiarrhoeal effect manifested by significant decrease in charcoal intestinal travelling distance & percent (ITP) which is similar to atropine sulphate (0.1 mg/kgBW IP) for the high DS extract dose.

   • According to Shrama M (2021)

     Excerpt stramonium commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. The present review aims to summarize the phytochemical composition & pharmacological & toxicological aspects of the plant Datura.

   • According to Asati V (2019)

     Excerpt Wide variety of pharmacological activities of different species of DS have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. The aim of present study is to investigate the anti-inflammatory activity of seed extract of DS against carrageenan induced paw edema model in albino wistar rats.

   • According to Agarwal R (2019)

     Excerpt Wide variety of pharmacological activities of different species of datura have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. Datura stramonium has been used for curing various ailments including ulcer, wounds, gout, fever, asthma, toothache etc.

   • According to Author (2017)

     Excerpt The previous pharmacological studies of Datura fastuosa showed that it possessed antimicrobial insecticidal, antidiabetic, cytotoxic, antioxidant, antiinflammatory, analgesic, antipyretic, neurological, wound healing, reproductive & antispasmodic, while Datura stramonium exerted Antiepileptic, Anti-asthmatic, analgesic, antioxidant, antimicrobial, insecticidal, repellent & organophosphate protective effects. The preliminary phytochemical investigation was performed on methanolic & hydroalcoholic extract of Datura fastuosa (syn: Datura metel) revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids & phenolic compounds, while, phytochemical analysis of Datura stramonium showed that it contained alkaloids, saponins, tannins, steroids, flavonoids, phenols & glycosides.

3. 3

   Abnormal serum levels caused by methotrexate: ALP, AST, ALT, total cholesterol, HDL, total albumin, etc.

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Alum EU (2023)

     Excerpt Key findings MTX caused a significant (P<0.05) increase in serum activities of liver enzymes (AST, ALT & ALP) & levels of total cholesterol & low-density lipoprotein while the levels of total protein & albumin decreased significantly relative to the normal control. Thus, we investigated the effect of Datura stramonium ethanolic leaf extract (DSELE) supplementation in MXT-induced biochemical alterations in rats.

   • According to Nasir B (2020)

     Excerpt Leukemia induced in rats was affirmed by elevated serum levels of WBCs (7.78 ± 0.012 (× 103) /μl), bilirubin (7.56 ± 0.97 mg/dl), Thiobarbituric acid reactive substances (TBARs) (133.75 ± 2.61 nM/min/mg protein), decreased RBCs (4.33 ± 0.065 (× 106)/μl), platelets (344 ± 3.19 (× 103)/μl), total proteins (2.14 ± 0.11 g/dl), Glutathione S-transferases (GST) (81.01 ± 0.44 nM/min/ml), endogenous antioxidant enzymes levels & abnormal liver and kidney functionality in disease control rats. Datura stramonium (DS) & Datura inoxia (DI) are the two species chosen for this study.-Methods: total phenolic and flavonoid content (TPC & TFC) as well as antioxidant activity were assessed through colorimetric method.

   • According to Usha K (2009)

     Excerpt Present studies clearly showed strong antifungal activity of a concoction brewed from Datura stramonium, Calotropis gigantea, Azadirachta indica (neem) & cow manure (T1) followed by methanol-water (70/30 v/v) extracts of D stramonium, C gigantea & A indica (T2) against Fusarium mangiferae. This could be due to observed higher levels of nitrogen, phosphorus, potassium, calcium, magnesium, copper, zinc, iron and manganese in T1, followed by T2 when compared with T3(control).

   • According to MURTALA AA (2023)

     Excerpt MURTALA AA et al, Sub-chronic (Ninety Days) Toxicity Study of Hydroethanolic Leaf Extract of Datura stramonium L.

   • According to Bouzidi A (2011)

     Excerpt Bouzidi A et al, Toxicity studies of alkaloids of seeds of Datura stramonium & synthesis alkaloids in male rats.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.