Datura stramonium (Konkond-djab) : vertus médicinales en extraction alcoolique

Datura stramonium (Konkond-djab, Konkonb-chien, Konkonb-zonbi, Concombre-à-diable, Concombre-à-Chien, Concombre-à-Zombi, Devil’s Cucumber, Dog-cucumber, Zombie-cucumber) — famille Solanacées.

Synonymes scientifiques : Datura capensis-Benth, D laevis-L. f, D micropcarpa-Godtr, D Parviflora-Salisb, D tatula-L, Stramonium foetidum-S, S spinosum Lam., S vulgare Moench, S vulgatum Gaertn..

Sources externes reconnues associées à cette monographie : TRAMIL et Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 17 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 126 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Traitement adjuvant du carcinome hépatique & mammaire

   Partie usitée : Parties aeriennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Iqbal S (2017)

     Extrait Datura stramonium belongs to the family Solanaceae which is commonly dubbed as thorn apple or jimson weed, & is abundant throughout tropical & subtropical regions. in vitro cytotoxic activity for MCF7 (breast cancer) cell line was too studied by MTT reagent assay method.

   • Selon Gupta A (2016)

     Extrait The immunomodulatory potential of DS active fraction was assessed by i) MTT microcytotoxicity assay using A549 (lung carcinomas) & MCF-7 (breast cancer) cell lines & ii) analyzing the production of IL-2 and IFN-γ by human PBMC in the presence of active fraction. stramonium leaves on human peripheral blood mononuclear cells (PBMC) followed by assessment of cytotoxic abilities of immunomodulated PBMC toward cancer cells.

   • Selon Alum EU (2023)

     Extrait Thus, we investigated the effect of Datura stramonium ethanolic leaf extract (DSELE) supplementation in MXT-induced biochemical alterations in rats. Key findings MTX caused a significant (P<0.05) increase in serum activities of liver enzymes (AST, ALT & ALP) & levels of total cholesterol & low-density lipoprotein while the levels of total protein & albumin decreased significantly relative to the normal control.

   • Selon Nasir B (2020)

     Extrait Datura stramonium (DS) & Datura inoxia (DI) are the two species chosen for this study.-Methods: total phenolic and flavonoid content (TPC & TFC) as well as antioxidant activity were assessed through colorimetric method. Leukemia induced in rats was affirmed by elevated serum levels of WBCs (7.78 ± 0.012 (× 103) /μl), bilirubin (7.56 ± 0.97 mg/dl), Thiobarbituric acid reactive substances (TBARs) (133.75 ± 2.61 nM/min/mg protein), decreased RBCs (4.33 ± 0.065 (× 106)/μl), platelets (344 ± 3.19 (× 103)/μl), total proteins (2.14 ± 0.11 g/dl), Glutathione S-transferases (GST) (81.01 ± 0.44 nM/min/ml), endogenous antioxidant enzymes levels & abnormal liver and kidney functionality in disease control rats.

   • Selon Togola I (2023)

     Extrait The results of that study showed that three Datura species investigated have immunostimulant potential which could them to be useful in the treatment of breast & cervical cancers. The anti-inflammatory potential was estimated using cancer cells, by quantifying nitrites (NO) based on colorimetric method (Griess reaction) & the cell viability based on the WST-1 assay.

2. 2

   Diarrhée

   Partie usitée : Feuille. Profil pharmacologique documenté : Atropine-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Auteur (2013)

     Extrait Three experiments were performed, Exp-1 & Exp-2 were designed to study the antidiarrhoeal effect & the effect on enteropooling induced by castor oil for two treated groups (T1&T2) orally dosed with Datura stramonium leaves hydroethanolic extract at 50 &100mg/Kg BW. Exp-1 results showed that both DS extract doses caused a dose dependent antidiarrhoeal effect manifested by significant decrease in charcoal intestinal travelling distance & percent (ITP) which is similar to atropine sulphate (0.1 mg/kgBW IP) for the high DS extract dose.

   • Selon Shrama M (2021)

     Extrait stramonium commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. The present review aims to summarize the phytochemical composition & pharmacological & toxicological aspects of the plant Datura.

   • Selon Asati V (2019)

     Extrait Wide variety of pharmacological activities of different species of DS have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. The aim of present study is to investigate the anti-inflammatory activity of seed extract of DS against carrageenan induced paw edema model in albino wistar rats.

   • Selon Agarwal R (2019)

     Extrait Wide variety of pharmacological activities of different species of datura have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. Datura stramonium has been used for curing various ailments including ulcer, wounds, gout, fever, asthma, toothache etc.

   • Selon Auteur (2017)

     Extrait The previous pharmacological studies of Datura fastuosa showed that it possessed antimicrobial insecticidal, antidiabetic, cytotoxic, antioxidant, antiinflammatory, analgesic, antipyretic, neurological, wound healing, reproductive & antispasmodic, while Datura stramonium exerted Antiepileptic, Anti-asthmatic, analgesic, antioxidant, antimicrobial, insecticidal, repellent & organophosphate protective effects. The preliminary phytochemical investigation was performed on methanolic & hydroalcoholic extract of Datura fastuosa (syn: Datura metel) revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids & phenolic compounds, while, phytochemical analysis of Datura stramonium showed that it contained alkaloids, saponins, tannins, steroids, flavonoids, phenols & glycosides.

3. 3

   Anormalité des paramètres sériques causée par le Méthotrexate : ALP, AST, ALT, Cholesterol total, HDL, Albumine totale, etc…

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Alum EU (2023)

     Extrait Key findings MTX caused a significant (P<0.05) increase in serum activities of liver enzymes (AST, ALT & ALP) & levels of total cholesterol & low-density lipoprotein while the levels of total protein & albumin decreased significantly relative to the normal control. Thus, we investigated the effect of Datura stramonium ethanolic leaf extract (DSELE) supplementation in MXT-induced biochemical alterations in rats.

   • Selon Nasir B (2020)

     Extrait Leukemia induced in rats was affirmed by elevated serum levels of WBCs (7.78 ± 0.012 (× 103) /μl), bilirubin (7.56 ± 0.97 mg/dl), Thiobarbituric acid reactive substances (TBARs) (133.75 ± 2.61 nM/min/mg protein), decreased RBCs (4.33 ± 0.065 (× 106)/μl), platelets (344 ± 3.19 (× 103)/μl), total proteins (2.14 ± 0.11 g/dl), Glutathione S-transferases (GST) (81.01 ± 0.44 nM/min/ml), endogenous antioxidant enzymes levels & abnormal liver and kidney functionality in disease control rats. Datura stramonium (DS) & Datura inoxia (DI) are the two species chosen for this study.-Methods: total phenolic and flavonoid content (TPC & TFC) as well as antioxidant activity were assessed through colorimetric method.

   • Selon Usha K (2009)

     Extrait Present studies clearly showed strong antifungal activity of a concoction brewed from Datura stramonium, Calotropis gigantea, Azadirachta indica (neem) & cow manure (T1) followed by methanol-water (70/30 v/v) extracts of D stramonium, C gigantea & A indica (T2) against Fusarium mangiferae. This could be due to observed higher levels of nitrogen, phosphorus, potassium, calcium, magnesium, copper, zinc, iron and manganese in T1, followed by T2 when compared with T3(control).

   • Selon MURTALA AA (2023)

     Extrait MURTALA AA et al, Sub-chronic (Ninety Days) Toxicity Study of Hydroethanolic Leaf Extract of Datura stramonium L.

   • Selon Bouzidi A (2011)

     Extrait Bouzidi A et al, Toxicity studies of alkaloids of seeds of Datura stramonium & synthesis alkaloids in male rats.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.