Diodia sarmentosa (Lyenn-makônnèt) : medicinal properties in alcoholic extraction

Diodia sarmentosa (Lyenn-makônnèt, Lyenn-razié, Cornet vine, Thicket vine, Liane -à-cornette, Liane-à-halliers) — family Rubiacées.

Scientific synonyms : Diodia riparia -Sagot, D scandens-Benth, Spermacoce spinosa -Loefl, S aspera-Aubl.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 7 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 18 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Okoroafor FE (2024)

     Excerpt It evaluated the biochemical, antioxidant, & anti-tumour potentials of the DS leaf extract on diethylnitrosamine-induced hepatocellular carcinoma in adult albino Wistar rats. This is the first in vivo study on the anti-cancer activities of Diodia sarmentosa leaves.

   • According to Okoroafor FE (2019)

     Excerpt This research aimed at studying the biochemical, antioxidant & anti-tumorigenic potentials of the ethanol extract of Diodia sarmentosa on Uterine Leiomyoma, Benign Prostatic Hyperplasia & Hepatocellular carcinoma in adult albino Wistar rats. Benign Prostatic Hyperplasia was induced by daily subcutaneous injection of 10 mg/kg body weight of testosterone propionate for 28 days & Hepatocellular carcinoma was induced by oral administration of 20 mg/kg body weight of diethyl nitrosamine (DEN) dissolved in normal saline (0.9%) < given 5 times a week for 6 weeks.

   • According to Okoroafor FE (2024)

     Excerpt It evaluated the biochemical, antioxidant, & anti-tumour potentials of the DS leaf extract on diethylnitrosamine-induced hepatocellular carcinoma in adult albino Wistar rats. This is the first in vivo study on the anti-cancer activities of Diodia sarmentosa leaves.

   • According to Ezejiofor TIN (2019)

     Excerpt Biochemical & histopathological evidence of anticancer potentials of ethanolic leaves extract of Diodia sarmentosa (Sw) against diethyl nitrosamine-induced hepatocellular carcinoma in albino rats (Abstracts).

2. 2

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to ---Elechi NA (2020)

     Excerpt This study has investigated the antidiabetic potential of the extracts of Diodia sarmentosa (Rubiaceae) leaves on alloxan induced diabetic Wistar rats. Diabetes was induced by the intraperitoneal injection of 120mg/kg body weight of alloxan monohydrate to the rats.

   • According to Elechi NA (2020)

     Excerpt This study has investigated the antidiabetic potential of the extracts of Diodia sarmentosa (Rubiaceae) leaves on alloxan induced diabetic Wistar rats. Diabetes was induced by the intraperitoneal injection of 120mg/kg body weight of alloxan monohydrate to the rats.

   • According to OGHOGHO AI (2018)

     Excerpt This study demonstrates the hypoglycaemic & anti-diabetic activity of the aqueous ethanol extract & ethylacetate fractions of DS in alloxan-induced diabetic rats. Diodia sarmentosa (Rubiaceae) commonly called tropical button weed, has been used locally in the treatment of diabetes.

   • According to Ijomone OR (2018)

     Excerpt This study demonstrates the hypoglycaemic & anti-diabetic activity of the aqueous ethanol extract & ethylacetate fractions of Diodia sarmentosa in alloxan-induced diabetic rats. Diodia sarmentosa (Rubiaceae) commonly called tropical button weed, has been used locally in the treatment of diabetes.

   • According to Ezejiofor TIN (2020)

     Excerpt This study investigated the Free radical scavenging & antioxidant potential of ethanolic leaf extract of Diodia sarmentosa on high fat fed wistar rats. Free radical scavenging & antioxidant potential of ethanolic leaf extracts of Diodia sarmentosa on high fat fed Wistar rats.

3. 3

   Oxidative stress

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to EZEJIOFIR TIN (2022)

     Excerpt Conclusion: The ETOH extract of-DS eaves mitigated oxidative stress &< improved the impaired antioxidant system caused by uterine leiomyoma induction. Diodia sarmentosa leaves have gained application in the local treatment of certain ailments.

   • According to OKORO CA (2025)

     Excerpt This study explored the preliminary phytochemical composition, antioxidant properties, & Fourier transform infrared (FTIR) analysis of bioactive compounds in Diodia sarmentosa (DS) aerial parts 70% ethanol extract. Its extensive phytochemical profile, antioxidant efficacy & accompanying functional groups demonstrate its potential for managing ailments such as oxidative stress related diseases, warranting more research for potential pharmaceutical development & therapeutic applications,.

   • According to Ezejiofor TIN (2020)

     Excerpt This study investigated the Free radical scavenging & antioxidant potential of ethanolic leaf extract of Diodia sarmentosa on high fat fed wistar rats. Free radical scavenging & antioxidant potential of ethanolic leaf extracts of Diodia sarmentosa on high fat fed Wistar rats.

   • According to KORIE SC (2021)

     Excerpt Diodia sarmentosa (Sw) also known as Zimbabwe flora or Tropical button weed is a straggling or procumbent perennial herb that grows in evergreen forest, riverine vegetation & bush land. This study investigated the role of the ethanolic leaf extract of DS as a free radical scavenger, and an antioxidant in high fat diet fed Wistar rats.

   • According to Okoroafor FE (2024)

     Excerpt This is the first in vivo study on the anti-cancer activities of Diodia sarmentosa leaves. In the treated group, significant (P<0.05) improvements were recorded in the serum levels of glutathione peroxidase, superoxide dismutase, catalase, vitamin C, glutathione, & total antioxidant capacity compared to the positive control.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.