Dioscorea bulbifera (Koko-bourik) : medicinal properties in alcoholic extraction

Dioscorea bulbifera (Koko-bourik, Adon, Coco-à-bourrique) — family Dioscoréacées.

Scientific synonyms : Dioscorea anthropophagorum-A.Chev, D crispata-Roxb, D latifolia-Benth, D tamifolia-Salisb, D violacea-Baudon, Helmia bulbifera-(L.) Kunth, Polynome bulbifera -L.) Salisb.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 114 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal and liver cancer and sarcoma

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Guan XR (n.d.)

     Excerpt bulbifera is effective in treating a wide range of diseases, such as pharyngitis, goitre, pyogenic skin infections, orchitis & cancer. The possible reasons for its toxicity include the toxic effects of diosbulbin B & D on hepatocytes, the inhibition of antioxidant enzymes in liver mitochondria, & inhibition of enzymes that ordinarily metabolize the herb’s components.

   • According to Chinko BC (2016)

     Excerpt Key words; Dioscorea bulbifera, lipid profile,serum glucose, liver enzymes. The control group received distilled water while the experimental groups received hydromethanolic extracts of Dioscorea bulbifera at 20mg/kg, 50mg/kg and 100mg/kg.

   • According to Wang J (2011)

     Excerpt The present study was undertaken to investigate the gender-related liver injury induced by Dioscorea bulbifera, a traditional medicinal plant, in mice, & further explored its hepatotoxic chemical compound. Further, comparing the liver injury induced by Diosbulbin B isolated from DB with that induced by EF on the basis of chemical analysis for the amounts of Diosbulbin B in EF of DB, we found that Diosbulbin B could be the main hepatotoxic chemical compound in DB.

   • According to Wang J (2010)

     Excerpt Hepatic tissues were used to assay for the level of lipid peroxide (LPO), amounts of antioxidants such as glutathione, & activities of antioxidant-related enzymes for liver oxidative-antioxidative status in mice. Taken together, our results indicate that the EF contains the main toxic ingredients of DB rhizome, & the mechanism of hepatotoxicity induced by it may be due to liver oxidative stress injury in mice.

   • According to Tan X (2003)

     Excerpt To explore the liver-toxic fraction in Rhizoma of Dioscorea bulbifera. Direct bilirubin (DBil) & Glutamic-pyruvic transaminase (GPT) were examined, & liver index was measured.

2. 2

   Type II diabetes mellitus

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ghosh S (2012)

     Excerpt Two plants with significant traditional therapeutic potential, namely, Gnidia glauca & Dioscorea bulbifera, were tested for their efficiency to inhibit α-amylase & α-glucosidase. bulbifera were sequentially extracted with petroleum ether, ethyl acetate, & methanol as well as separately with 70% ethanol.

   • According to Chinko BC (2016)

     Excerpt The control group received distilled water while the experimental groups received hydromethanolic extracts of Dioscorea bulbifera at 20mg/kg, 50mg/kg and 100mg/kg. The present study is aimed at studying the biochemical effects of hydromethanolic extract of Dioscorea bulbifera on biochemical parameter using Wistar rats.

   • According to Ghosh S (2014)

     Excerpt This is the first report of its kind that provides an intense scientific rationale for use of diosgenin as novel drug candidate for type II diabetes mellitus,. Herein we report the promises of Dioscorea bulbifera & its bioactive principle, diosgenin as novel α-amylase & α-glucosidase inhibitor.

   • According to Maithili V (2011)

     Excerpt Indian J Pharmacol 2011; 43:455-9-Objective: To evaluate the antidiabetic activity of ethanolic extract of Dioscorea alata in glucose loaded & alloxan induced diabetic rats. Maithili V et al, Antidiabetic activity of ethanolic extract of tubers of Dioscorea alata in alloxan induced diabetic rats.

   • According to Eni Kalu S (2019)

     Excerpt Aerial yam (Dioscorea bulbifera) is an indigenous plant grown by few for food. Information also has it that it is used by rural diabetes patients.

3. 3

   Diabetic retinopathy

   Plant part used: Tuber.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ghosh S (2012)

     Excerpt Two plants with significant traditional therapeutic potential, namely, Gnidia glauca & Dioscorea bulbifera, were tested for their efficiency to inhibit α-amylase & α-glucosidase. bulbifera were sequentially extracted with petroleum ether, ethyl acetate, & methanol as well as separately with 70% ethanol.

   • According to Chinko BC (2016)

     Excerpt The control group received distilled water while the experimental groups received hydromethanolic extracts of Dioscorea bulbifera at 20mg/kg, 50mg/kg and 100mg/kg. The present study is aimed at studying the biochemical effects of hydromethanolic extract of Dioscorea bulbifera on biochemical parameter using Wistar rats.

   • According to Ghosh S (2014)

     Excerpt This is the first report of its kind that provides an intense scientific rationale for use of diosgenin as novel drug candidate for type II diabetes mellitus,. Herein we report the promises of Dioscorea bulbifera & its bioactive principle, diosgenin as novel α-amylase & α-glucosidase inhibitor.

   • According to Maithili V (2011)

     Excerpt Indian J Pharmacol 2011; 43:455-9-Objective: To evaluate the antidiabetic activity of ethanolic extract of Dioscorea alata in glucose loaded & alloxan induced diabetic rats. Maithili V et al, Antidiabetic activity of ethanolic extract of tubers of Dioscorea alata in alloxan induced diabetic rats.

   • According to Eni Kalu S (2019)

     Excerpt Aerial yam (Dioscorea bulbifera) is an indigenous plant grown by few for food. Information also has it that it is used by rural diabetes patients.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.