Dodonea viscosa : medicinal properties in alcoholic extraction

Dodonea viscosa (Mang-lozèy, Mangle-oseille) — family Sapindacées.

Scientific synonyms : Dodonea ehrenbergii-Schdtl., Dodonea viscosa-(L)-Lacq..

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 19 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 102 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Muthukumran P (2011)

     Excerpt The different extracts of the Dodonaea viscosa were tested for anti-diabetic activity, by glucose tolerance test in normal rats & alloxan induced diabetic rats. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol & urea levels on 0,3,5,7 & 10th day.

   • According to AHMAD M (2012)

     Excerpt It is concluded from the study that aqueous: methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihyperlipidemic & hepatoprotective effects in the alloxan-induced diabetic rabbits,. The present study was conducted to determine the antihyperlipidemic & hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits.

   • According to Akhtar MS (2011)

     Excerpt Antidiabetic folkloric use of Dodonaea (D.) viscosa leaves was evaluated in normal and alloxan-diabetic rabbits. In addition, synergistic hypoglycemic effects of oral intake of A-M extract (representing 500 mg/kg) along with different doses of insulin were studied in diabetic rabbits.

   • According to Veerapur VP (2010)

     Excerpt Veerapur VP et al, Antidiabetic effect of Dodonaea viscosa (L) Lacq aerial parts in high fructose-fed insulin resistance rats: A mechanism-based study, Indian J of Experimental Biol, 48, 2010, 800-10.

   • According to Meenu I (2011)

     Excerpt Meenu I et al, EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF DODONAEA VISCOSA LEAVES IN NORMAL & STZ-DIABETIC RATS, Inter J of Pharm & Pharmaceut Sci, 3 Suppl 3, 2011.

2. 2

   Liver disorders: cirrhosis, hepatitis, liver fibrosis

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shalaby N (2012)

     Excerpt viscosa ethanol extract & two fractions were examined in vivo against liver fibrosis induced by CCl4 in rats. The work was extended to measure serum protein content & liver function enzymes; aspartate and alanine aminotransferases (AST and ALT), alkaline phosphatase (ALP) & gamma glutamyl transferase (GGT).

   • According to AHMAD M (2012)

     Excerpt The oral administration of aqueous: methanol (70:30) extract of the Dodonaea viscosa leaves significantly (P<0.01) decreased the raised parameters (triglyceride, total cholesterol & LDL-cholesterol) to normal values. It is concluded from the study that aqueous: methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihyperlipidemic & hepatoprotective effects in the alloxan-induced diabetic rabbits,.

   • According to Ali (2014)

     Excerpt In the present study we investigated the hepatoprotective potential of the methanolic extract of the whole plant of DV & its ethyl acetate, aqueous, butanol & n-hexane fractions against carbon tetrachloride (CCl₄) induced hepatoxicity in rats. HPLC fingerprinting suggested that Hautriwaic acid present in the methanolic extract & its ethyl acetate, & aqueous fractions may be responsible for this hepatoprotective activity of DV which was confirmed by in vivo experiments,.

   • According to Tong ZW (2021)

     Excerpt The intake of DV extracts restored the level of hepatic enzymes (ALP, AST ALT, & Direct bilirubin), hematological parameters (RBCs, WBCs, & Platelets), total protein, & liver antioxidant enzymes (SOD, GPx, and CAT) after a decline in levels by CCL4. Dodonaea viscosa flowers are found to have a protective effect against oxidative stress produced by CCL4 in the liver, kidney, & spleen.

   • According to CAO S (2009)

     Excerpt 5 A southern Brazilian outbreak of acute hepatic insufficiency in which 14 dairy animals died after consumption of D viscosa has been reported. Liquid-liquid partitioning of a portion of an EtOH extract of the roots of D viscosa into hexane, CH2Cl2 & aqueous MeOH fractions indicated that the CH2Cl2 fraction (326.5 mg) was the most active fraction, with an IC50 value of 1.0 μg/mL.

3. 3

   Cancer: adjuvant treatment for breast cancer

   Plant part used: flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shafek RE (2015)

     Excerpt The main objective of this present work is to find out good pharmacological activities in herbal source with their phytochemical study, which is aimed to investigate of 80% ethanolic extract of Dodonaea Viscosa flowers for their antioxidant, analgesic & cytotoxic activities. Its cytotoxic activity against breast carcinoma cell line (MCF7) showed IC50 19.4 μg/ml compared with the standard used (Cisplatin), which its IC50 is 5.48μg/ml.

   • According to BREVET (n.d.)

     Excerpt The invention disclosed herein relates to the use of an extract of Dodonaea viscosa in breast cancer therapy, either alone or in combination with other breast cancer therapies.

   • According to Rehman S (2023)

     Excerpt This study aimed to assess the anti-rheumatic potential of Dodonaea viscosa to evaluate its bioactive small molecules for their beneficial effects in the management of rheumatoid arthritis. viscosa (ethanol extract) had drug-like properties.

   • According to CAO S (2009)

     Excerpt Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). In this paper, we report the isolation, structure elucidation, & antiproliferative activity of two new triterpenoid saponins (1 & 2) obtained from the roots of D viscosa.

   • According to Anandan M (2018)

     Excerpt The gold Nanoparticles with distinct morphologies were synthesized using Dodonaea viscosa leaf extract in different polar/non polar solvents.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.