Echinacea purpurea (Purple Echinacea) : medicinal properties in alcoholic extraction

Echinacea purpurea (Purple Echinacea, Purple rudbeckia, Échinacée pourpre, rudbeckie pourpre) — family Astéracées.

Scientific synonyms : Brauneria purpurea (L.) Britton, Echinacea serotina (Sweet) D. Don, Rudbeckia purpurea L. Helichroa purpurea (L.) R.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 14 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 125 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Delorme D (2005)

     Excerpt The NOD (non-obese diabetic) mouse is currently regarded as an excellent animal model of human Type 1 diabetes. Based on this hypothesis, & the fact that the herb, Echinacea, is a well demonstrated immunostimulant of NK cells in normal mice/humans, we aimed to investigate, in NOD mice, the effect of short term (days) & long term (months) daily dietary administration of Echinacea, on the absolute levels of NK cells, & five other classes of hemopoietic & immune cells, in the bone marrow and spleen.

   • According to Chiou SY (2017)

     Excerpt The extraction yield, total phenols, Caffeic acid derivatives (CAD), & antioxidant properties of 50% ethanolic Echinacea purpurea flower extract were determined. purpurea extract & CAD have good potential for managing hyperglycemia & hypertension.

   • According to Aarland RC (2017)

     Excerpt Materials & methods: Density, dry matter, phenols (Folin-Ciocalteu method), flavonoids (AlCl3method), alkylamides (GC-MS analysis), antioxidant capacity (DPPH a&ABTS methods), antiproliferative effect (SRB assay), anti-inflammatory effect (paw oedema assay, 11 days/Wistar rats; 0.4 mL/kg) & hypoglycaemic effect (33 days/Wistar rats; 0.4 mL/kg) were determined in three Echinacea extracts which were labelled as A, B & C (A, roots of Echinacea purpurea L. Moench; B, roots, leaves, flowers & seeds of Echinacea purpurea; C, aerial parts & roots of Echinacea purpurea & roots of Echinacea angustifolia DC).

   • According to Mao CF (2018)

     Excerpt Echinacea purpurea ethanol extract (EE) contains phenolic acid & isobutylamides had been proven to ameliorate diabetic complications. The results show that the nano-EE5 can improve hyperglycemia, insulin resistance, and plasma fibroblast growth factor 21 (FGF 21) resistance.

2. 2

   Viræmia: influenza A virus, strain H1N1 (PR8)

   Plant part used: Aerial parts. Mentioned synergistic association: association synergique avec HUMULUS LUPULUS-L (Fleur).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Percaccio E (2023)

     Excerpt In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) & the cones of Humulus lupulus L. Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant & inflammatory stimuli & its antiviral efficacy against the PR8/H1N1 influenza virus were assayed.

   • According to Merali S (2003)

     Excerpt Antifungal & anti-inflammatory activity of the genus Echinacea.

   • According to Author (2012)

     Excerpt Extracts of Echinacea purpurea (EP, purple Coneflower) have been used traditionally in North America for the treatment of various types of infections & wounds, & they have become very popular herbal medicines globally. Recent studies have revealed that certain standardized preparations contain potent & selective antiviral & antimicrobial activities.

   • According to Binns SE (2002)

     Excerpt Antiviral activity of characterized extracts from Echinacea spp. (Heliantheae: Asteraceae) against herpès simplex virus (HSV-I).

   • According to Binns SE (2000)

     Excerpt Light-mediated antifungal activity of Echinacea extracts.

3. 3

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Tsai YL (2012)

     Excerpt The aims of this study were to provide a preliminary validation of the effects of 50% aqueous ethanol extract of E purpurea flowers & its major compound, Chicoric acid, on human colon cancer cells Caco-2 & HCT-116. MATERIALS & METHODS: The cytotoxic effects of Echinacea flower extracts & Chicoric acid on cell viability, telomerase activity, DNA fragmentation, β-catenin, caspase-9, & cleavage of poly-ADP-ribose polymerase (PARP) of human colon cancer cell were examined.

   • According to Lersch CM (1992)

     Excerpt Two months after onset of therapy a partial tumor regression was documented in one and a stable disease in 6 other patients by abdominal ultrasonography, decrease of the tumor markers carcinoembryonic antigen (CEA), CA 19-9, CA 15-3, and/or chest roentgenography, which may also be attributed to the natural course of disease. Outpatients (n = 15) with metastasizing far advanced colorectal cancers received immunotherapy consisting of low-dose cyclophosphamide (LDCY) 300 mg/m2 every 28 days i.v.

   • According to Mac-Cann DA (2007)

     Excerpt PBMCs from vaccinated individuals were stimulated in vitro with Echinacea tinctures & influenza virus; cytokine production (IL-2, IL-10, & interferon-gamma [IFN-gamma]) was compared prevaccination & postvaccination. In the first set of experiments, PBMCs were stimulated in vitro with tinctures alone & assayed for proliferation & production of interleukin-10 (IL-10), IL-12, & tumor necrosis factor-alpha (TNF-alpha).

   • According to Steinmuller C (1993)

     Excerpt Polysaccharides (EP) isolated from large scale plant cell cultures of Echinacea purpurea, have been shown to activate human & murine phagocytes. EP-treated macrophages exhibited increased production of tumor necrosis factor-alpha (TNF) and enhanced cytotoxicity against tumor target WEHI 164 as well as against the intracellular parasite Leishmania enriettii.

   • According to Aarland RC (2017)

     Excerpt Materials & methods: Density, dry matter, phenols (Folin-Ciocalteu method), flavonoids (AlCl3method), alkylamides (GC-MS analysis), antioxidant capacity (DPPH a&ABTS methods), antiproliferative effect (SRB assay), anti-inflammatory effect (paw oedema assay, 11 days/Wistar rats; 0.4 mL/kg) & hypoglycaemic effect (33 days/Wistar rats; 0.4 mL/kg) were determined in three Echinacea extracts which were labelled as A, B & C (A, roots of Echinacea purpurea L. Moench; B, roots, leaves, flowers & seeds of Echinacea purpurea; C, aerial parts & roots of Echinacea purpurea & roots of Echinacea angustifolia DC).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.