Eclipta alba (Podjak) : medicinal properties in alcoholic extraction

Eclipta alba (Podjak, Kongo-Lala) — family Astéracées.

Scientific synonyms : Cotula alba-L, Eclipta alba-(L)-Kuntze, E brachypoda-Michx, E erecta-L, E prostata-L, E punctata-L, Eupatoriophalacron album-(L)-Hitch, Verbesina alba-L, V prostata-L.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 31 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 153 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: chemoprevention of liver cancer, kidney cancer, hormone-dependent breast cancer and glioma (anti-metastatic action)

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xia Y (2013)

     Excerpt The purpose of this study was to demonstrate the anti-fibrotic effects of wedelolactone on activated human hepatic stellate cell (HSC) line LX-2 & the possible underlying mechanisms by means of MTT assay, Hoechst staining, as well as real-time quantitative PCR & western blot. Wedelolactone is a major coumarin of Eclipta prostrata, which is used for preventing liver damage.

   • According to Singh B (1993)

     Excerpt An alcoholic extract of freshly collected Eclipta alba exhibited dose-dependent (62.5–500.0 mg/kg p.o.) significant hepatoprotective activity against carbon tetrachloride-induced liver injury in rats & mice.

   • According to Pandey M. K (2011)

     Excerpt The present study confirmed the antibacterial potential of aerial parts extracts of E alba in solvents like acetone, ethanol, methanol, aqueous & hexane against selected gram positive & gram-negative bacterial species.

   • According to Vasuki R (2012)

     Excerpt A comparative analysis in evaluating the hepatoprotective action of ethanolic extract of Eclipta alba (EAE) & Piper longum (PLE) with their combination Biherbal extract (BHE) against carbon tetrachloride (CCl 4) induced hepatic damage is reported in albino rats. The results strongly indicate that BHE has more potent hepato-protective action than EAE or PLE individually against CCl 4 induced hepatic damage in rats.

   • According to Author (1985)

     Excerpt BREVET : 3525363A1-Allemagne-1985: Process for the preparation of extracts of Eclipta alba standardized for wedelolactone and/or desmethyl-wedelolactone and use of the extracts for the preparation of a liver therapeutic : The invention relates to a process for the preparation of extracts of Eclipta alba standardized for wedelolactone and/or desmethy-lwedelolactone, which is characterized by the following stages: (a) extraction of the dried, pulverized above-ground constituents of the plant Eclipta alba with methanol and/or ethanol (b) digestion of the alcohol extract freed from the solvent with water at a temperature of up to 80 DEG C, (c) filtration of the aqueous extract, (d) extraction by shaking of the aqueous extract with an inert organic solvent which is poorly miscible or immiscible with water, (e) performance of a qualitative and quantitative HPLC standardization of the enriched fraction obtained

   • according to (a) to (d) under the following conditions

     Excerpt use of a column packed with reverse phase and acid-containing acetonitrile/water mixtures or methanol/water mixtures as the solvent, & use of the external standard method for the quantitative determination of wedelolactone and/or desmethyl-wedelolactone by means of their peak surface areas. An extract standardized in this way can be used for the preparation of an antihepatotoxic & hepatoprotective medicament.

2. 2

   Type II diabetes mellitus

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ahmad R (2008)

     Excerpt Eclipta alba Hassk (Asteraceae) whole plant, roots of Berberis aristata DC (Berbidaceae), stem wood of Betula utilis D. (Myristcaceae) exhibited 7.5, 8.3, 9.2, 6.0, & 8.7% significant fall in blood glucose profile in a single dose experiment on Streptozotocin-induced diabetic rats.

   • According to Ananthi J (2003)

     Excerpt Eclipta alba, an indigenous medicinal plant, has a folk (Siddha & Ayurvedha) reputation in rural southern India as a hypoglycemic agent. In order to confirm this claim, the present study was carried out to evaluate the antihyperglycemic effect of E.A & to study the activities of liver hexokinase & gluconeogenic enzymes such as glucose-6-phosphatase & fructose 1,6-bisphosphatase in the liver of control & alloxan-diabetic rats.

   • According to Jaiswal N (2012)

     Excerpt Antidiabetic effect of Eclipta Alba associated with the inhibition of α-glucosidase & aldose reductase.

   • According to PHAN TKP (2022)

     Excerpt These findings align with the traditional use of EPL for enhancing memory and cognitive function, as well as its potential benefits in diabetes management.

3. 3

   Bacterial infection: Salmonella typhi, Salmonella paratyphi, Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae, Proteus mirabilis

   Plant part used: Aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Karthikkumar S (2007)

     Excerpt the hexane, ethyl acetate, ethanol & water extract of aerial parts of the Eclipta prostrata were tested for its antibacterial activities against Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Highest activity of both antibacterial & antioxidant was observed only in ethanol & ethyl acetate extracts, while hexane & water extracts did not show any significant results.

   • According to Uddin N (2010)

     Excerpt Large zone of inhibition was observed in disc diffusion Antibacterial screening against gram negative Salmonella typhi, Shigella sonnei, Escherichia coli, Salmonella paratyphi, Pseudomonas sp (1) & Pseudomonas sp (II), & gram-positive Bacillus subtilis, Bacillus Cereus, Bacillus megaterim & Staphylococcus aureus at the concentration of 1mg/disc. this study was subjected to investigate antioxidant, Cytotoxic & antimicrobial (Antibacterial & Antifungal) properties of Eclipta alba ethanol extract.

   • According to Pandey M. K (2011)

     Excerpt The present study confirmed the antibacterial potential of aerial parts extracts of E alba in solvents like acetone, ethanol, methanol, aqueous & hexane against selected gram positive & gram-negative bacterial species.

   • According to Selvamani S (2014)

     Excerpt Methanol extract of the plant had higher inhibitory action against Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis & Pseudomonas fluorescens. The antibacterial activity of Eclipta alba against three gram positive & five-gram negative bacterial strains were investigated.

   • According to Rangineni V (2007)

     Excerpt Rangineni V et al, Diuretic, hypotensive, & Hypocholesterolemic effects of Eclipta alba in mild Screening of antibacterial & antioxidant activities of leaves of Eclipta prostrata hypertensive subjects: a pilot study.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.