Eruphorbia heterophylla (Gwo-Malonmen) : medicinal properties in alcoholic extraction

Eruphorbia heterophylla (Gwo-Malonmen, Grosse Mal-nommée) — family Euphorbiacées.

Scientific synonyms : Euphorbia geniculata Ortega, E prunifolia Jacq., Poinsettia geniculata (Ortega) Klotzsch & Garcke, P Heterophylla (L.) Klotzsch & Garcke..

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 42 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, fatty liver

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Pimentel Da Silva U (n.d.)

     Excerpt heterophylla dispersion, studies on the medicinal properties of specimens collected in Brazil are lacking.

   • According to SUJA RANI D (2023)

     Excerpt Objective: The present investigation aimed to evaluate the hepatoprotective potentials of ethanol extract of Euphorbia heterophylla leaves against ethanol-induced liver damage in rats. But in the animals treated with ETOH extract of EH (EEEH) & standard drug silymarin, all the parameters were normal, possibly due to their beneficial property in protecting the liver against ethanol-induced hepatotoxicity.

   • According to Vani M (2017)

     Excerpt The present investigation has been carried out to evaluate the in vitro & in vivo antihistaminic & anticholinergic activities for the stem extracts of Euphorbia heterophylla, Preliminary phytochemical screening have been carried out on the hydroalcoholic & acetone extracts of the plant. Therefore, stem extracts of EH can be used as antihistaminic & anticholinergic agents which suggest their usage for various therapeutic ailments such as asthma, liver damage, inflammation, & ulcer etc.

   • According to Okolie NP (2015)

     Excerpt ALT did not follow a definite pattern, initially significantly decreasing in plasma & then increasing at the higher extract dose, while the activity of the enzyme significantly increased dose-dependently in the liver (P < 0.05). Although the use of Euphorbia heterophylla as herbal laxative in Nigeria is associated with severe & sometimes life-threatening side effects, not much is known about the toxic effect of the herb.

2. 2

   Bacterial infection: Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Adedoyin BJ (2013)

     Excerpt Antimicrobial activity tests carried out against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pneumonia & Candida albicans, revealed moderate to low activity against the test organisms. Essential oils were extracted from Euphorbia heterophylla plant (Spurge Weed) using the hydro distillation Clevenger method.

   • According to Ughachukwu PO (2014)

     Excerpt Materials & methods: Clinical isolates of Klebsiella pneumonia, Staphyllococcus aureus, Escherichia coli, & Pseudomonas aeruginosa were incubated in agar plates after serial dilutions (100, 50, 25, 12.5, 6.25, & 3.16 mg/ml) of the extract were added in wells made in the agar & incubated at 37°C. This work evaluated the antibacterial actions of aqueous ethanol leaf extract of Euphorbia heterophylla.

   • According to Kone JK (2021)

     Excerpt The microorganisms tested were nine clinical bacterial strains which included Pseudomonas aeruginosa, Pseudomonas aeruginosa NCIB 950, Salmonella typhi, Escherichia coli, Escherichia coli NCIB 86, Staphylococcus aureus, Staphylococcus aureus NCIB 8588, Klebsiella pneumoniae & Serratia marcescens, & seven fungal strains which were Candida albicans, Aspergillus fumigatus, Aspergillus flavus, Aspergillus parasiticus, Trichoderma viride, Trichophyton rubrum, & Malassezia furfur. Pseudomonas aeruginosa, Pseudomonas aeruginosa NCIB 950 & Candida albicans were sensitive to the cold water a hot water extracts of the plant's parts while chloroform & methanol extracts did not show antimicrobial activities against any of the organisms.

   • According to Ughachukwu PO (2014)

     Excerpt Materials & methods: Clinical isolates of Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, & Pseudomonas aeruginosa were incubated in agar plates after serial dilutions (100, 50, 25, 12.5, 6.25, & 3.16 mg/ml) of the extract were added in wells made in the agar & incubated at 37°C. This work evaluated the antibacterial actions of aqueous ethanol leaf extract of Euphorbia heterophylla.

   • According to Author (2014)

     Excerpt Antibacterial analysis was carried out using agar well diffusion assay against eight pathogenic strains of gram-positive, gram-negative bacteria (Neisseria gonorrhea, Salmonella typhi, Pseudomonas aureginosa, Proteus vulgaris, Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia & Bacillus subtilis) & four different fungal species (Aspergillusniger, Aspergillus tamari, Candida albicans & Fusarium oxysporium). Phytochemical studies revealed the presence of tannins, anthraquinones, alkaloids, flavonoids & phenols in hexane, acetone & water extracts containing only phenol.The plant extracts demonstrated antimicrobial activity against both the test bacteria & fungi with water extract demonstrating the highest activity followed by the acetone extract.

3. 3

   Cancer: adjuvant treatment for ascites carcinoma

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sundaram MM (2010)

     Excerpt Alcoholic extract of plant material showed significant in-vitro cytotoxic activity on EAC (Ehrlich ascites carcinoma) cell lines. Euphorbia heterophylla is a local medicinal plant used in ethno medicine for the treatment of constipation, bronchitis & asthma.

   • According to Falodun A (2012)

     Excerpt The anti-proliferative & apoptotic effects of the methanol extract on human breast cancer cell line (MCF-7) were also investigated by flow cytometry. Euphorbia heterophylla Linn (Euphorbiaceae) is a medicinal plant used in ethnomedicine for the treatment of constipation, bronchitis & asthma.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.