Garcinia mangostana (Mangosteen) : medicinal properties in alcoholic extraction

Garcinia mangostana (Mangosteen, Mangoustan) — family Clusiacées.

Scientific synonyms : Garcinia malaccensis-Hook f., Mangostana Garcinia-Gaertn.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 163 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment of oral, leukaemic, liver, colorectal and squamous cell carcinoma, as well as melanoma and breast cancer

   Plant part used: Fruit (pericarp).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ho CK (2002)

     Excerpt We extracted & purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana, using partitioned chromatography & then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric & lung cancer cell lines included in the screen.

   • According to Abood WN (2020)

     Excerpt mangostana (250 mg/kg and 500 mg/kg) with TAA showed a significant reduction in liver index a&hepatocyte proliferation with much lesser cell damage. mangostana peel on the histology, immunohistochemistry, a&biochemistry of thioacetamide (TAA) induced liver cirrhosis in Sprague Drawly (SD) rats.

   • According to KOENIASARI SETIAWAN (n.d.)

     Excerpt From the results of this study concluded that the mangosteen pericarp extracts could be a potent natural herbal product provide a promising hepatoprotective effect against lead acetate induced hepato toxicity in mice. This study was carried to investigate the role of ethanol extract of mangosteen pericarp in protecting against lead acetate-induced hepatoxicity in male mice.

   • According to Abuzaid AS (2016)

     Excerpt This study evaluated the preventive effect of mangosteen pericarp ethanolic extract (MPEE) on obesity by measuring body weight changes and fatty acid synthase (FAS) concentration in the adipose tissue and serum of monosodium glutamate and high-calorie diet-induced male Wistar rats.

   • According to Abuzaid AS (n.d.)

     Excerpt This study was conducted to evaluate the mangosteen ( Garcinia mangostana ) pericarp ethanolic extract (MPEE) properties in preventing obesity as well as its associated metabolic syndrome by analyzing the liver histology & measuring resistin, leptin, and adiponectin in the rats fed high-fat diet. The rats treated with MPEE have the better liver condition than untreated rats, showed by lower histopathological score and lipid droplets, as well as higher percentage of functional cytoplasm.

2. 2

   Diabetic glomerulosclerosis

   Plant part used: Fruit (pericarp).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Widowati W (2018)

     Excerpt MPE activity has correlates to inhibit the diabetic glomerulosclerosis condition & may increase mesangial cell proliferation.

   • According to TAHER M (2016)

     Excerpt mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats. Various parts of Garcinia mangostana Linn including its pericarp, have been traditionally used to treat a variety of ailments.

   • According to Mohammed GA (2022)

     Excerpt Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities. These results could further provide new insight into the potential usage of GM as a functional food for regulating postprandial hyperglycemia via suppressing AA,.

   • According to Nganlasom J (2008)

     Excerpt leaves & Garcinia Mangostana Linn. hull on the healing of dermal wounds in diabetic rats.

   • According to Palanisamy UD (2014)

     Excerpt This was followed by the extracts from Syzygium cumini (leaf), Nephelium lappaceum, Syyzgium aqueum & Garcinia mangostana.(rind) Interestingly, it was observed that these extracts displayed activities comparable & at times higher than the commercial anti-glycemic drug; Acarbose, & the commercial grape seed extract. It is worthy to note that S cumini, has been shown to display anti-diabetic activities in sreptozotocin induced rat studies (Kumar et al., 2008).

3. 3

   Type II diabetes mellitus

   Plant part used: Fruit (pericarp).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to TAHER M (2016)

     Excerpt mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats. Various parts of Garcinia mangostana Linn including its pericarp, have been traditionally used to treat a variety of ailments.

   • According to Widowati W (2018)

     Excerpt MPE activity has correlates to inhibit the diabetic glomerulosclerosis condition & may increase mesangial cell proliferation.

   • According to Mohammed GA (2022)

     Excerpt Garcinia mangostana (Clusiaceae) is a rich pool of metabolites with diversified bioactivities. These results could further provide new insight into the potential usage of GM as a functional food for regulating postprandial hyperglycemia via suppressing AA,.

   • According to Nganlasom J (2008)

     Excerpt leaves & Garcinia Mangostana Linn. hull on the healing of dermal wounds in diabetic rats.

   • According to Palanisamy UD (2014)

     Excerpt This was followed by the extracts from Syzygium cumini (leaf), Nephelium lappaceum, Syyzgium aqueum & Garcinia mangostana.(rind) Interestingly, it was observed that these extracts displayed activities comparable & at times higher than the commercial anti-glycemic drug; Acarbose, & the commercial grape seed extract. It is worthy to note that S cumini, has been shown to display anti-diabetic activities in sreptozotocin induced rat studies (Kumar et al., 2008).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.