Gardenia jasminoides (Cape jasmine) : medicinal properties in alcoholic extraction

Gardenia jasminoides (Cape jasmine, Jasmin du Cap) — family Rubiacées.

Scientific synonyms : Gardenia angusta –(L.) Merr., Genipa florida (L.) Baill, G grandiflora-Lour, Jasminum capense-Mill.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 141 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to LI N (2019)

     Excerpt In vitro & in vivo studies have further identified the value of geniposide in a spectrum of preclinical models of diabetes mellitus (DM) & cardiovascular disorders. Geniposide, an iridoid glucoside, is a major component in the fruit of Gardenia jasminoides Ellis (Gardenia fruits).

   • According to Wu S (2009)

     Excerpt Geniposide is an iridoid glucoside extracted from Gardenia jasminoides Ellis fruits & has been reported to have a hypoglycemic effect. Results: Geniposide (200 & 400 mg/kg) significantly decreased the blood glucose, insulin & TG levels in diabetic mice in a dose-dependent manner.

   • According to Zhou A (2023)

     Excerpt To evaluate the effect of gardenia & its different extracts on type 2 diabetes mellitus (T2DM) in in vivo & in vitro experiments, the dried gardenia powder was extracted using 60% ethanol & eluted at different ethanol concentrations to obtain the corresponding purified fragments. For many centuries, Gardenia (Gardenia jasminoides Ellis) was highly valued as a food homologous Chinese herbal medicine with various bioactive compounds, including crocin I & geniposide.

   • According to Liu H (2013)

     Excerpt Numerous studies have confirmed that crocins & iridoid glycosides had effects of antioxidation, anti-inflammatory, anti-atherosclerosis, anti-ischemic brain injuries, anti-platelet aggregation, anti-hyperglycemia, anti-hyperlipidemia, anti-hypertension, & so on. The phytochemistry, cardiovascular pharmacology, toxicology, side effect, and further development prospects of Gardenia jasminoidesJ.

   • According to LIU L (2022)

     Excerpt Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Gardenia jasminoides Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects & biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, & other protective effects.

2. 2

   Cancer: adjuvant treatment for gastric carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Lv K (2021)

     Excerpt Geniposide (GEN), one of the main iridoid glycosides in gardenia fruit, has been widely reported to have anti-cancer effects. Besides, Live/Dead staining, Hematoxylin-Eosin (H&E) staining & SEM evaluation were also conducted to estimate the anti-cancer effect of GEN in 2D & 3D cultures.

   • According to Cho YS (2022)

     Excerpt Genipin is a protein cross-linking agent extracted from Gardenia (Gardenia jasminoides Ellis) fruits. Genipin also increases the tissue inhibitors of matrix metalloproteases (MMP)-2, a kind of tumor promoter in a variety of cancers, as well as induces caspase-dependent apoptosis in in vitro & in vivo models.

   • According to Wang X (2018)

     Excerpt Gardenia jasminoides Ellis (GJE) is an herbal medicine possessing multiple pharmacological effects on human health with low toxicity. Importantly, the MTT results showed that exposure of breast cancer cells to the three compounds resulted in reduction of cell viability, demonstrating the cytotoxicity of the three compounds.

   • According to LIU L (2022)

     Excerpt Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Gardenia jasminoides Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects & biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, & other protective effects.

   • According to Sung YY (n.d.)

     Excerpt Gardenia jasminoides has been used in traditional medicine for treatment of inflammation, edema, & dermaitis. Both GJE & GJE-EA reduced the expression of cytokines (interleukin [IL]-4, IL-6, & tumor necrosis factor-alpha) & adhesion molecules (intercellular adhesion molecule-1 & vascular cell adhesion molecule-1) in ear lesions.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to LI N (2019)

     Excerpt Geniposide has been experimentally proved to possess multiple pharmacological actions involving antioxidative stress, anti-inflammatory, antiapoptosis, antiangiogenesis, antiendoplasmic reticulum stress (ERS), etc. Geniposide, an iridoid glucoside, is a major component in the fruit of Gardenia jasminoides Ellis (Gardenia fruits).

   • According to Fu Y (2012)

     Excerpt Geniposide, a main iridoid glucoside component of gardenia fruit, has been known to exhibit antibacterial, anti-inflammatory & other important therapeutic activities. These results suggest that geniposide exerts an anti-inflammatory property by down-regulating the expression of TLR4 up-regulated by LPS.

   • According to Chen L (2020)

     Excerpt Various pharmacological properties, such as a beneficial effect on the nervous, cardiovascular & digestive systems, hepatoprotective activity, antidepressant activity, & anti-inflammatory activity, were also validated in vitro & in vivo. Gardenia jasminoides Ellis is a popular shrub in the Rubiaceae family.

   • According to Koo HJ (2006)

     Excerpt However, genipin possessed stronger anti-inflammatory activity than geniposide, as demonstrated by the results with carrageenan-induced rat paw edema, carrageenan-induced air pouch formation, & measurement of NO content in the exudates. GFE, genipin, & geniposide showed acute anti-inflammatory activities in carrageenan-induced rat paw edema.

   • According to Lim H (2008)

     Excerpt The fruits of Gardenia jasminoides have been previously reported to possess anti-inflammatory activity. All of these results suggest that genipin may contribute to anti-inflammatory activity of the fruits of GJ & an inhibitory action on prostaglandin & NO production is, at least, the part of anti-inflammatory mechanism of genipin.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.