Guaiacum officinale (Gayak) : medicinal properties in alcoholic extraction

Guaiacum officinale (Gayak, Gaïac) — family Zygophyllacées.

Scientific synonyms : Guaiacum bijugum-Stokes, Guajacum officinale-L.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 4 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 14 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Adjuvant treatment for diabetic foot

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bahado-Singh PlS (2014)

     Excerpt & G officinale in an excision wound model of normal & streptozotocin induced type I diabetic rats. Jamaican Ball Moss (Tillandsia recurvata sp.) & Lignum Vitae (Guaiacum officinale) are indigenous to the West Indian region & have been widely studied & used as ethnomedicinal remedies to treat numerous diseases.

   • According to Ibrahim S (2019)

     Excerpt The aim of present study is to evaluate the antidiabetic & hepatoprotective effect of Guaiacum officinale in streptozotocin induced male albino rats. The SGOT level significantly reduced in GO treated group as compare to control, pronounced reduction of ALT level as compared to GLB & the ALP levels was highly significantly reduced in Guaiacum officinale treated group while GLB is unable to improve ALP levels in GLB treated diabetic albino rats.

   • According to Sarkar A (2014)

     Excerpt The aim of the present study was to evaluate the anti-rheumatic & anti-oxidant activity of homeopathic preparations of Guaiacum officinale on experimental animal model. Design: Rheumatoid arthritis (RA) was induced in male albino rats by Freund's complete adjuvant (FCA) at a dose of (0.25 mg heat killed Mycobacterium tuberculosis/ml of emulsion).

   • According to Duwiejua M (1994)

     Excerpt The aqueous ethanolic extracts of Polygonum bistorta, Polygonaceae, Guaiacum officinale-Zygophyllaceae & Hamamelis virginiana Hamamelidaceae were screened for anti-inflammatory activity. The extract (200 mg kg-1), administered after the onset of the inflammatory responses reversed the course of both the carrageenan- & adjuvant-induced rat paw swelling.

2. 2

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bahado-Singh PlS (2014)

     Excerpt Jamaican Ball Moss (Tillandsia recurvata sp.) & Lignum Vitae (Guaiacum officinale) are indigenous to the West Indian region & have been widely studied & used as ethnomedicinal remedies to treat numerous diseases. The anti-tumor properties of the TC have been the centre of recent discussions, however, both plants are quite popular among Jamaican folklore medicine as effective anti-inflammatory remedies in the treatment of arthritic & rheumatic conditions.

   • According to Ibrahim S (2019)

     Excerpt The aim of present study is to evaluate the antidiabetic & hepatoprotective effect of Guaiacum officinale in streptozotocin induced male albino rats. The SGOT level significantly reduced in GO treated group as compare to control, pronounced reduction of ALT level as compared to GLB & the ALP levels was highly significantly reduced in Guaiacum officinale treated group while GLB is unable to improve ALP levels in GLB treated diabetic albino rats.

   • According to Shoukat S (2021)

     Excerpt The present work is an attempt to find out biological potential of various extracts & ethanol fractions of Guaiacum officinale. No toxic effect was experienced against the normal cell line, showing it is safe in cancer therapy.

   • According to Lowe H (2014)

     Excerpt In our search for plants with anticancer and anti-infective properties, we evaluated Guaiacum officinale for activity against HIV-1. Guaiacum officinale is the “National Flower”, with reported uses in folk medicine for the treatment of various conditions including inflammation.

   • According to Sarkar A (2014)

     Excerpt The aim of the present study was to evaluate the anti-rheumatic & anti-oxidant activity of homeopathic preparations of Guaiacum officinale on experimental animal model. Design: Rheumatoid arthritis (RA) was induced in male albino rats by Freund's complete adjuvant (FCA) at a dose of (0.25 mg heat killed Mycobacterium tuberculosis/ml of emulsion).

3. 3

   Bacterial infection: Escherichia coli

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Askari S (2021)

     Excerpt In the present study, we used the ethanolic & methanolic extracts of Terminalia cattapa, Guaiacum officinale, Conocarpus erectus, Prosopis juliflora, Ziziphys nummularia, & Moringa oleifera to deterimine antimicrobial potential of these plants against pathogenic clinical isolates. G officinale only inhibited the growth of Escherichia coli while no inhibitory effect was observed by the extracts of ZN & MO.

   • According to Shoukat S (2021)

     Excerpt The present work is an attempt to find out biological potential of various extracts & ethanol fractions of Guaiacum officinale. The antimicrobial potential was tested against pathogenic bacteria by a well diffusion process & only one strain (S.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.