Guazuma ulmifolia (Bwa-dôm) : medicinal properties in alcoholic extraction

Guazuma ulmifolia (Bwa-dôm, Elm wood, Bois d’Orme) — family Sterculiacée.

Scientific synonyms : Guazuma polybotrya-Cav, G tomentosa-HBK, G guazuma-(L)-Cockerell, Theobroma guazuma-L.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 28 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Diabetic glomerulosclerosis

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Prahastuti S (2019)

     Excerpt Guazuma ulmifolia leaf is well known as an Indonesian traditional medicine to have effects as antidiabetic by the presence of its secondary metabolites such as alkaloid, tannin, saponin, flavonoid, & terpenoid, which are very important in health recovery. Conclusion: Our study suggests that EEJB is able to reduce TGF-β1, fibronectin, & ROS levels in glucose-induced mesangial cells, which correlate to diabetic glomerulosclerosis condition & increase the mesangial cell proliferation & viability.

   • According to Adnyana K (2013)

     Excerpt Adnyana K et al, Antidiabetic activity of aqueous leaf extracts of Guazuma ulmifolia Lamk., ethanolic extracts of Curcuma xanthorrhiza & their combinations in alloxan-induced diabetic mice, Research J of Med Plant, 7(3) :158–64, 2013.

   • According to Alonso-Castro AJ (2008)

     Excerpt Alonso-Castro AJ et al, the anti-diabetic properties of Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal & diabetic adipocytes without inducing adipogenesis, J of Ethnopharmacol, 118(2): 252–6, 2008.

   • According to Berenguer B (2007)

     Excerpt The flowers and leaves of Guazuma ulmifolia, though less studied, are also used as a remedy for different conditions, such as kidney and gastrointestinal diseases, fever and diabetes. The aim of this study was to assess the gastroprotective effects of an aqueous suspension of the ethanolic extract from leaves and flowers of Guazuma ulmifolia in a model of acute gastric ulcer induced by diclofenac as ulcerogenic agent, using the proton pump inhibitor omeprazole as a protection reference.

2. 2

   Cancer: side effects associated with doxorubicin chemotherapy

   Plant part used: stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to -LUKMAN M (2014)

     Excerpt Gmelina arborea Roxb, Guazuma ulmifolia Lamk & Curculigo orchioides Gaerth, the three plants frequently used in South Sulawesi for the treatment of cancerous diseases, have been selected to examine their action in cervical epithelial carcinoma. These extracts were assessed using HeLa cell cancer (Human cervix cancer) & doxorubicin was used as the positive control.

   • According to Dos Santos JM (2018)

     Excerpt In this study, we evaluated (I) the chemical composition & antioxidant capacity of aqueous extracts from Guazuma ulmifolia stem bark (GUEsb) & leaves (GUEl) in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2-azobis(2-amidinopropane) dihydrochloride- (AAPH-) or DOX-induced lipid peroxidation inhibition in human blood cells, & intracellular reactive oxygen species (ROS) quantification using the fluorescent probe dichloro-dihydro-fluorescein diacetate (DCFH-DA) in K562 erythroleukemia cells incubated with GUEsb & stimulated with hydrogen peroxide; (II) the viability of K562 cells & human leukocytes treated with GUEsb in the absence or presence of DOX using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; (III) the acute toxicity of GUEsb; and (IV) the cardioprotective effect of GUEsb in C57Bl/6 mice treated with DOX. Taken together, the results show that GUEsb & GUEl are natural alternatives to treat diseases associated with oxidative stress & that, in particular, GUEsb may play an adjuvant role in DOX chemotherapy.

   • According to MAURINO Dos SANTOS J (2018)

     Excerpt In this study, we evaluated (I) the chemical composition & antioxidant capacity of aqueous extracts from G ulmifolia stem bark (GUEsb) & leaves (GUEl) in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2-azobis(2-amidinopropane) dihydrochloride- (AAPH-) or DOX-induced lipid peroxidation inhibition in human blood cells, and intracellular reactive oxygen species (ROS) quantification using the fluorescent probe dichloro-dihydro-fluorescein diacetate (DCFH-DA) in K562 erythroleukemia cells incubated with GUEsb and stimulated with hydrogen peroxide; (II) the viability of K562 cells and human leukocytes treated with GUEsb in the absence or presence of DOX using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (MTT) assay; (III) the acute toxicity of GUEsb; and (IV) the cardioprotective effect of GUEsb in C57Bl/6 mice treated with DOX. Taken together, the results show that GUEsb and GUEl are natural alternatives to treat diseases associated with oxidative stress and that, in particular, GUEsb may play an adjuvant role in DOX chemotherapy.

   • According to ISWANTINI D (2011)

     Excerpt (Bangle), Guazuma ulmifolia Lamk. In this research, water content determination, phytochemical assay, toxicity assay & in vitro assay of inhibition activity on pancreatic lipase were performed toward single and mixture extracts of Z.

   • According to Póvoa Violante IM (2012)

     Excerpt (Simaroubaceae), Guazuma ulmifolia Lam. Toxicity of the extracts and fractions against Artemia salina was also evaluated in this work.

3. 3

   Gastric ulcer

   Plant part used: Aerial part.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Berenguer B (2007)

     Excerpt The aim of this study was to assess the gastroprotective effects of an aqueous suspension of the ethanolic extract from leaves and flowers of Guazuma ulmifolia in a model of acute gastric ulcer induced by diclofenac as ulcerogenic agent, using the proton pump inhibitor omeprazole as a protection reference. The flowers and leaves of Guazuma ulmifolia, though less studied, are also used as a remedy for different conditions, such as kidney and gastrointestinal diseases, fever and diabetes.

   • According to MORAIS SM (2017)

     Excerpt The antioxidant activity combined with anticholinesterase potential corroborates, in part, with the use of GU in the treatment of gastrointestinal disorders. The chemical study of the ethanol extract from G ulmifolia leaves revealed the presence of flavonoids and phenolic acids with recognized antioxidant potential.

   • According to Póvoa Violante IM (2012)

     Excerpt (Simaroubaceae), Guazuma ulmifolia Lam. The results tend to support the traditional use of these plants for the treatment of respiratory & gastrointestinal disorders and/or skin diseases, opening the possibility of finding new antimicrobial agents from these natural sources.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.