Guazuma ulmifolia (Bwa-dôm) : vertus médicinales en extraction alcoolique

Guazuma ulmifolia (Bwa-dôm, Bois d’Orme, Elm wood) — famille Sterculiacée.

Synonymes scientifiques : Guazuma polybotrya-Cav, G tomentosa-HBK, G guazuma-(L)-Cockerell, Theobroma guazuma-L.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 15 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 28 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Glomerulosclérose du diabétique

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Prahastuti S (2019)

     Extrait Guazuma ulmifolia leaf is well known as an Indonesian traditional medicine to have effects as antidiabetic by the presence of its secondary metabolites such as alkaloid, tannin, saponin, flavonoid, & terpenoid, which are very important in health recovery. Conclusion: Our study suggests that EEJB is able to reduce TGF-β1, fibronectin, & ROS levels in glucose-induced mesangial cells, which correlate to diabetic glomerulosclerosis condition & increase the mesangial cell proliferation & viability.

   • Selon Adnyana K (2013)

     Extrait Adnyana K et al, Antidiabetic activity of aqueous leaf extracts of Guazuma ulmifolia Lamk., ethanolic extracts of Curcuma xanthorrhiza & their combinations in alloxan-induced diabetic mice, Research J of Med Plant, 7(3) :158–64, 2013.

   • Selon Alonso-Castro AJ (2008)

     Extrait Alonso-Castro AJ et al, the anti-diabetic properties of Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal & diabetic adipocytes without inducing adipogenesis, J of Ethnopharmacol, 118(2): 252–6, 2008.

   • Selon Berenguer B (2007)

     Extrait The flowers and leaves of Guazuma ulmifolia, though less studied, are also used as a remedy for different conditions, such as kidney and gastrointestinal diseases, fever and diabetes. The aim of this study was to assess the gastroprotective effects of an aqueous suspension of the ethanolic extract from leaves and flowers of Guazuma ulmifolia in a model of acute gastric ulcer induced by diclofenac as ulcerogenic agent, using the proton pump inhibitor omeprazole as a protection reference.

2. 2

   Cancer : troubles associés à la chimiotherapie par la Doxorubicine

   Partie usitée : écorce de Tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon -LUKMAN M (2014)

     Extrait Gmelina arborea Roxb, Guazuma ulmifolia Lamk & Curculigo orchioides Gaerth, the three plants frequently used in South Sulawesi for the treatment of cancerous diseases, have been selected to examine their action in cervical epithelial carcinoma. These extracts were assessed using HeLa cell cancer (Human cervix cancer) & doxorubicin was used as the positive control.

   • Selon Dos Santos JM (2018)

     Extrait In this study, we evaluated (I) the chemical composition & antioxidant capacity of aqueous extracts from Guazuma ulmifolia stem bark (GUEsb) & leaves (GUEl) in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2-azobis(2-amidinopropane) dihydrochloride- (AAPH-) or DOX-induced lipid peroxidation inhibition in human blood cells, & intracellular reactive oxygen species (ROS) quantification using the fluorescent probe dichloro-dihydro-fluorescein diacetate (DCFH-DA) in K562 erythroleukemia cells incubated with GUEsb & stimulated with hydrogen peroxide; (II) the viability of K562 cells & human leukocytes treated with GUEsb in the absence or presence of DOX using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; (III) the acute toxicity of GUEsb; and (IV) the cardioprotective effect of GUEsb in C57Bl/6 mice treated with DOX. Taken together, the results show that GUEsb & GUEl are natural alternatives to treat diseases associated with oxidative stress & that, in particular, GUEsb may play an adjuvant role in DOX chemotherapy.

   • Selon MAURINO Dos SANTOS J (2018)

     Extrait In this study, we evaluated (I) the chemical composition & antioxidant capacity of aqueous extracts from G ulmifolia stem bark (GUEsb) & leaves (GUEl) in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2-azobis(2-amidinopropane) dihydrochloride- (AAPH-) or DOX-induced lipid peroxidation inhibition in human blood cells, and intracellular reactive oxygen species (ROS) quantification using the fluorescent probe dichloro-dihydro-fluorescein diacetate (DCFH-DA) in K562 erythroleukemia cells incubated with GUEsb and stimulated with hydrogen peroxide; (II) the viability of K562 cells and human leukocytes treated with GUEsb in the absence or presence of DOX using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (MTT) assay; (III) the acute toxicity of GUEsb; and (IV) the cardioprotective effect of GUEsb in C57Bl/6 mice treated with DOX. Taken together, the results show that GUEsb and GUEl are natural alternatives to treat diseases associated with oxidative stress and that, in particular, GUEsb may play an adjuvant role in DOX chemotherapy.

   • Selon ISWANTINI D (2011)

     Extrait (Bangle), Guazuma ulmifolia Lamk. In this research, water content determination, phytochemical assay, toxicity assay & in vitro assay of inhibition activity on pancreatic lipase were performed toward single and mixture extracts of Z.

   • Selon Póvoa Violante IM (2012)

     Extrait (Simaroubaceae), Guazuma ulmifolia Lam. Toxicity of the extracts and fractions against Artemia salina was also evaluated in this work.

3. 3

   Ulcère gastrique

   Partie usitée : Partie aérienne.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Berenguer B (2007)

     Extrait The aim of this study was to assess the gastroprotective effects of an aqueous suspension of the ethanolic extract from leaves and flowers of Guazuma ulmifolia in a model of acute gastric ulcer induced by diclofenac as ulcerogenic agent, using the proton pump inhibitor omeprazole as a protection reference. The flowers and leaves of Guazuma ulmifolia, though less studied, are also used as a remedy for different conditions, such as kidney and gastrointestinal diseases, fever and diabetes.

   • Selon MORAIS SM (2017)

     Extrait The chemical study of the ethanol extract from G ulmifolia leaves revealed the presence of flavonoids and phenolic acids with recognized antioxidant potential. The antioxidant activity combined with anticholinesterase potential corroborates, in part, with the use of GU in the treatment of gastrointestinal disorders.

   • Selon Póvoa Violante IM (2012)

     Extrait (Simaroubaceae), Guazuma ulmifolia Lam. The results tend to support the traditional use of these plants for the treatment of respiratory & gastrointestinal disorders and/or skin diseases, opening the possibility of finding new antimicrobial agents from these natural sources.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.