Hedyotis corymbosa : medicinal properties in alcoholic extraction

Hedyotis corymbosa (Mil-Grenn, Lang-poul, Lizimak, Mille graines, Langue-à-poule, Lysimaque) — family Rubiacées.

Scientific synonyms : Oldenlandia corymbosa-L, Rudgea corymbosa-L.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 15 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 48 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatitis, cirrhosis, normalisation of transaminases (SGOT and SGPT), poisoning

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chimkode R (n.d.)

     Excerpt Hence the present study was aimed to investigate the hepatoprotective activity of ethanolic extract of Hedyotis corymbosa which was separated in to different fractions against carbon tetrachloride In toxification. The elevated levels of SGOT & SGPT were significantly decreased by ether and butanol fractions at P<0.001 & butanone & Ethanol at p < 0.05, whereas petroleum ether & ethyl acetate did not show any significant reduction in the level of SGOT & SGPT.

   • According to Sadasivam S (2006)

     Excerpt In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of Hedyotis corymbosa against paracetamol overdose-induced liver damage in Wistar rats was studied. The methanolic extract of the plant produced significant hepatoprotective effects as evidenced by decreased serum enzyme activities, SGPT, SGOT, SAKP and serum bilirubin & an almost normal histological architecture of the liver, in treated groups, compared to the controls.

   • According to Rathi MA (2009)

     Excerpt The present study was designed to evaluate the hepatoprotective effect of Hedyotis corymbosa belongs (family Rubiaceae) on perchloroethylene induced damage in rat liver. The results of this study strongly indicate that Hedyotis corymbosa have potent hepatoprotective action against perchloroethylene induced hepatic damage in rats,.

   • According to Sultana T (2010)

     Excerpt Sultana T et al, Hepatoprotective & Antibacterial Activity of Ursolic Acid Extracted from Hedyotis corymbosa L.

   • According to Gajakosh AM (2015)

     Excerpt Gajakosh AM et al, Phytochemical & Pharmacognostic investigation on Oldenlandia corymbosa (l.) Lamk an important hepatoprotective medicinal plant.

2. 2

   Type II diabetes mellitus

   Plant part used: aerial parts.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ramprasad R (2010)

     Excerpt This finding tells the utilization of ethanolic extract of aerial plant of Oldenlandia corymbosa is effective in inhibiting α-glucosidase thereby proving to be potential antidiabetic agent. Postprandial hyperglycaemia which was focused in the therapy for diabetes was the prime characteristic of diabetes mellitus.

3. 3

   Cancer: adjuvant treatment for advanced breast cancer

   Plant part used: Whole plant. Mentioned synergistic association: Annona muricata-feuille.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Endrini S (2015)

     Excerpt In this study, soursop & Pearl grass combined to obtain extracts that have anticancer effects & anti-inflammatory effects, as most patients with cancer, particularly advanced breast cancer often experience inflammation. Soursop (Annona muricata) has numerous traditional medicinal uses in South American & the Caribbean & it has become a popular nutritional medicinal supplement.

   • According to Endrini S (2015)

     Excerpt The objective of this study was to determine the cytotoxicity of soursop (Annona muricata Linn) leaves & pearl grass (Hedyotis corymbosa (L.) Lam.) on the hormone-dependent human breast carcinoma Michigan Cancer Foundation-7 (MCF-7) cell line. Soursop (Anona muricata Linn) leaves have the strongest cytotoxic activity against MCF-7 breast cancer cell line,"}.

   • According to Haryanti S (2009)

     Excerpt The aim of this research is to examine the cytotoxic activity of herb ethanolic extract (ERM) and its effect in combination with doxorubicin against MCF-7 breast cancer cell line as cell model of doxorubicin resistance. with ursolic acid as the main compound is one of the plants that has been used for traditional medicine including to cure Breast cancer disease.

   • According to Andriyani R (2011)

     Excerpt Some fractions of Hedyotis corymbosa extract has been analyzed using Sulforhodamine B method with UV wavelength 515 nm against T47D cell line, a human breast cancer. Finding a herbal medicine for cancer treatment is a first step to find a right cancer medicine in the future.

   • According to ROLLANDO R (2018)

     Excerpt Ursolic acid was a compound found in Hedyotis corymbosa L., (HCoL) while berberine found in Tinospora crispa (TCa) which are proven to have cytotoxic effect to cancer cells. This research aims to review the effect of cisplatin, ethanolic extract of HCoL & TCa to the sensitivity increase on breast cancer cells, which will be confirmed through apoptosis induction & cell cycle modulation.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.