Hedyotis corymbosa (Mil-Grenn) : vertus médicinales en extraction alcoolique

Hedyotis corymbosa (Mil-Grenn, Lang-poul, Lizimak, Mille graines, Langue-à-poule, Lysimaque) — famille Rubiacées.

Synonymes scientifiques : Oldenlandia corymbosa-L, Rudgea corymbosa-L.

Sources externes reconnues associées à cette monographie : TRAMIL.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 15 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 48 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Hépatite, cirrhose, normalisation des transaminases (SGOT et SGPT), intoxication

   Partie usitée : Plante entière.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Chimkode R (s.d.)

     Extrait Hence the present study was aimed to investigate the hepatoprotective activity of ethanolic extract of Hedyotis corymbosa which was separated in to different fractions against carbon tetrachloride In toxification. The elevated levels of SGOT & SGPT were significantly decreased by ether and butanol fractions at P<0.001 & butanone & Ethanol at p < 0.05, whereas petroleum ether & ethyl acetate did not show any significant reduction in the level of SGOT & SGPT.

   • Selon Sadasivam S (2006)

     Extrait In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of Hedyotis corymbosa against paracetamol overdose-induced liver damage in Wistar rats was studied. The methanolic extract of the plant produced significant hepatoprotective effects as evidenced by decreased serum enzyme activities, SGPT, SGOT, SAKP and serum bilirubin & an almost normal histological architecture of the liver, in treated groups, compared to the controls.

   • Selon Rathi MA (2009)

     Extrait The present study was designed to evaluate the hepatoprotective effect of Hedyotis corymbosa belongs (family Rubiaceae) on perchloroethylene induced damage in rat liver. The results of this study strongly indicate that Hedyotis corymbosa have potent hepatoprotective action against perchloroethylene induced hepatic damage in rats,.

   • Selon Sultana T (2010)

     Extrait Sultana T et al, Hepatoprotective & Antibacterial Activity of Ursolic Acid Extracted from Hedyotis corymbosa L.

   • Selon Gajakosh AM (2015)

     Extrait Gajakosh AM et al, Phytochemical & Pharmacognostic investigation on Oldenlandia corymbosa (l.) Lamk an important hepatoprotective medicinal plant.

2. 2

   Diabète mellitus de type II

   Partie usitée : Parties aériennes. Profil pharmacologique documenté : Acarbose-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Ramprasad R (2010)

     Extrait Postprandial hyperglycaemia which was focused in the therapy for diabetes was the prime characteristic of diabetes mellitus. This finding tells the utilization of ethanolic extract of aerial plant of Oldenlandia corymbosa is effective in inhibiting α-glucosidase thereby proving to be potential antidiabetic agent.

3. 3

   Cancer : traitement adjuvant de carcinome mammaire avancé

   Partie usitée : Plante entière. Association synergique mentionnée : Annona muricata-feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Endrini S (2015)

     Extrait In this study, soursop & Pearl grass combined to obtain extracts that have anticancer effects & anti-inflammatory effects, as most patients with cancer, particularly advanced breast cancer often experience inflammation. Soursop (Annona muricata) has numerous traditional medicinal uses in South American & the Caribbean & it has become a popular nutritional medicinal supplement.

   • Selon Endrini S (2015)

     Extrait The objective of this study was to determine the cytotoxicity of soursop (Annona muricata Linn) leaves & pearl grass (Hedyotis corymbosa (L.) Lam.) on the hormone-dependent human breast carcinoma Michigan Cancer Foundation-7 (MCF-7) cell line. Soursop (Anona muricata Linn) leaves have the strongest cytotoxic activity against MCF-7 breast cancer cell line,"}.

   • Selon Haryanti S (2009)

     Extrait The aim of this research is to examine the cytotoxic activity of herb ethanolic extract (ERM) and its effect in combination with doxorubicin against MCF-7 breast cancer cell line as cell model of doxorubicin resistance. with ursolic acid as the main compound is one of the plants that has been used for traditional medicine including to cure Breast cancer disease.

   • Selon Andriyani R (2011)

     Extrait Some fractions of Hedyotis corymbosa extract has been analyzed using Sulforhodamine B method with UV wavelength 515 nm against T47D cell line, a human breast cancer. Finding a herbal medicine for cancer treatment is a first step to find a right cancer medicine in the future.

   • Selon ROLLANDO R (2018)

     Extrait Ursolic acid was a compound found in Hedyotis corymbosa L., (HCoL) while berberine found in Tinospora crispa (TCa) which are proven to have cytotoxic effect to cancer cells. This research aims to review the effect of cisplatin, ethanolic extract of HCoL & TCa to the sensitivity increase on breast cancer cells, which will be confirmed through apoptosis induction & cell cycle modulation.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.