Heliotropium indicum (Krèt-Kodenn) : medicinal properties in alcoholic extraction

Heliotropium indicum (Krèt-Kodenn, Zèb-èskôpion, Crète-à-coq-d ’inde, herbe-scorpion) — family Boraginacées.

Scientific synonyms : Heliotropium cordifolium-Moench, H horminifolium-Mill, Tiaridium indicum-Lehm.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 72 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for squamous cell lung cancer

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Moongkarndi P (2004)

     Excerpt niruri] whole plant, Passiflora foetida aerial part, Ardisia elliptica fruit, Morinda citrifolia fruit, Aegle marmelos fruit, Heliotropium indicum whole plant, Stephania venosa [Stephania rotunda] bulb a& Thunbergia laurifolia leaf) were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. However, all the plant extracts showed activity in potential range for further investigation on cancer cells,.

   • According to Chunthorng-Orn J (2016)

     Excerpt Objective: In the present study, we investigated cytotoxicity against two types of lung cancer cell lines (A549 & NCI-H226), anti-inflammatory effect & antioxidant activity of HI extracts. The cytotoxic activity against two types of human lung cancer cell lines (A549 & NCI-H226) was evaluated by sulforhodamine B (SRB) assay.

   • According to Author (2016)

     Excerpt indicum exhibited IC50 of 67.23 mg/ml & 72.23 mg/ml for chloroform & ethanol fraction respectively, where good cytotoxicity were shown against HeLa cell line with IC50 values of 58.43 mg/ml ad 64.23 mg/ml for chloroform & ethanol fraction respectively. Human prostate cancer cell line (PC-3) & Human cervical cancer cell line were exposed to chloroform & ethanol extract of V.

   • According to Sivajothi V (2015)

     Excerpt Results: The results showed that the methanolic extracts of stem & leaf of H indicum possessed a good amount of anticancer activity & IC50 for both the extracts found to be 200µg/ml. The study was performed using methanolic extracts against human cancer cell line (HeLa) using MTT assay to analyze the cell growth inhibition.

   • According to Singh B (2017)

     Excerpt The review paper contains the critical information of ethnomedicinal properties of each species of Heliotropium genus, the occurrence of pyrrolizidine alkaloids, the biological & pharmacological properties of pyrrolizidine alkaloids. Conclusion: The findings of this review paper validate the significance of pyrrolizidine alkaloids, their occurrence & biosynthesis in Heliotropium species, as well as their biological & pharmacological properties.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Whole plant.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Roy A (2015)

     Excerpt Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’, is a herb with pale violet flowers belonging to the family Boraginaceae & is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive & diuretic activities.

   • According to Hamiduzzaman (2017)

     Excerpt Hamiduzzaman et al, Evaluation of Anti-Inflammatory Activity through Assaying the Stability of Erythrocytes’ Membrane by Different Organic Extracts of Heliotropium Indicum (Boraginaceae), J.

   • According to Shalini. S (2010)

     Excerpt S et al, Study on the anti-inflammatory activity of Heliotropium indicum, JITPS .1 (1), 43–6, 2010.

   • According to Betanabhatla KS (2007)

     Excerpt Choloroform extract of Heliotropium indicum was investigated for anti-inflammatory & anti-nociceptive activities in experimental animal models. Anti-inflammatory activity was evaluated with carrageenan induced paw edema model in albino Wistar rats of both sexes, & compared to a positive control drug, Diclofenac sodium.

   • According to Author (2000)

     Excerpt Anti-inflammatory activity of Heliotropium indicum Linn & Leucas aspera Spreng.

3. 3

   Allergy, bronchospasm

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Shenoy A (2011)

     Excerpt The findings from various studies reveal that the antihistaminic & antianaphylactic activity of H indicum may be due to the mast cell stabilizing potential, suppression of IgE, & inhibition of release of inflammatory mediators. Heliotropium indicum significantly prolonged the latent period of convulsion (P <0.008) as compared to control following exposure of guinea pigs to histamine aerosol.

   • According to Roy A (2015)

     Excerpt Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’, is a herb with pale violet flowers belonging to the family Boraginaceae & is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive & diuretic activities.

   • According to Betanabhatla KS (2007)

     Excerpt Choloroform extract of Heliotropium indicum was investigated for anti-inflammatory & anti-nociceptive activities in experimental animal models. Anti-inflammatory activity was evaluated with carrageenan induced paw edema model in albino Wistar rats of both sexes, & compared to a positive control drug, Diclofenac sodium.

   • According to Hamiduzzaman (2017)

     Excerpt Hamiduzzaman et al, Evaluation of Anti-Inflammatory Activity through Assaying the Stability of Erythrocytes’ Membrane by Different Organic Extracts of Heliotropium Indicum (Boraginaceae), J.

   • According to Author (2000)

     Excerpt Anti-inflammatory activity of Heliotropium indicum Linn & Leucas aspera Spreng.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.