Hibiscus sabdariffa (Gwozèy-Djinen) : medicinal properties in alcoholic extraction

Hibiscus sabdariffa (Gwozèy-Djinen, Guinean redcurrant, Groseille de guinée) — family Malvacées.

Scientific synonyms : Hibiscus cruentus-Bertol.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 23 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 126 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Infected wound, incision, injury, diabetic foot: Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae

   Plant part used: Flower Chalice.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Abbas HA (2014)

     Excerpt This study aimed to study the antibacterial & antibiofilm activities of the ethanolic extract of Hibiscus sabdariffa & apple vinegar alone & in combination against one strong biofilm forming strain of each of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis & Klebsiella pneumoniae. coli at 8X MIC, P aeruginosa at 16X MIC, S epidermidis, P mirabilis & S aureus (32X MIC).

   • According to AMOS A (2022)

     Excerpt Recent studies have investigated the uses of Hibiscus sabdariffa to treat common chronic diseases.Its antihypertensive potential originates from the vasodilator activity, diuretic efficacy, functionality as an ACE inhibitor, adipocyte differentiation inhibitor, heart rate reduction ability, & anti-inflammatory mechanistics.The antihyperlipidemic effect is dose-dependent & stems from the antioxidative effect & the activation of AMPK through phosphorylation & also the inhibition of regulatory adipogenic transcription factors PPAR-γ, C/EBP-α & SREBP-1c which all together results in lipid-lowering effect.As an antihyperglycemic, HS serves as anti-insulin resistance by inhibition of the phosphorylation of IRS-1 beside the similar effect to gliptins.HS was proven to protect against neuroinflammation in microglial cell culture exposed to LPS by decreasing IL-1, IL-6, TNF-α expression, & the protective effect against glucotoxicity, improve memory function by inhibiting the formation of hyperphosphorylated tau proteins in the mouse brain. The databases PubMed, MEDLINE, Clinical Key, & CINAHL were searched for studies related to Hibiscus sabdariffa's compounds, antioxidative & anti-inflammatory features, mechanism of action on common chronic diseases including hypertension, hyperlipidemia, obesity, diabetes, & Alzheimer's disease.

   • According to Adeyemi D (2019)

     Excerpt This study evaluated the antidiabetic potentials of flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx (HSCE) on the pancreatic β-cells of experimental type I diabetic model rats. The study concluded that possible antidiabetic mechanism of Hibiscus sabdariffa in STZ diabetes is through induction of β-cell regeneration & its strong antioxidant potential.

   • According to Rosidah R (2014)

     Excerpt Then the test of Antidiabetic activity was conducted consisting of 11 treatment groups, ie groups of CMC suspension 0.5% as a negative control; Glibenclamide 0.65 mg/kg as a positive control; n-hexane extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg; ethyl acetate extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg & ethanol extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg & 600 mg / kg, which is respectively administered orally every day. The results of the statistical test (α = 0.05) showed that the extracts of n-hexane & ethyl acetate perform a real mean of difference on Glibenclamide, whereas the ethanol extract did not perform significant differences with Glibenclamide in lowering blood glucose levels on mice, which means that the ethanol extract can lower blood glucose levels of diabetic mice.

   • According to Fullerton M (2011)

     Excerpt Determination of antimicrobial activity of sorrel (Hibiscus sabdariffa) on Escherichia coli O157:H7 isolated from food, veterinary, & clinical samples.

2. 2

   Cancer: adjuvant treatment for hepatocellular carcinoma and multiple myeloma

   Plant part used: Flower Chalice.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Mahadevan N (2009)

     Excerpt The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer & antioxidant properties. Hibiscus sabdariffa Linn.

   • According to Lin HH (2007)

     Excerpt Hibiscus sabdariffa Linné (Malvaceae), an attractive plant believed to be native to Africa, is cultivated in the Sudan and Eastern Taiwan. Using a set of apoptotic detection assays, they showed that HSE induced cytotoxicity and apoptosis of AGS cells in a concentration-dependent manner but is ineffective in Chang liver cells.

   • According to Famurewa AC (2019)

     Excerpt By contrast, ZD administration attenuated & restored the markers of liver injury, hepatic antioxidant enzymes & lipid peroxidation near to control, while histopathological alterations were ameliorated compared to the MTX group. MTX induced prominent oxidative hepatotoxicity demonstrated by significant (p < .01) increases in serum liver enzymes & bilirubin, while protein profile was markedly reduced (p < .05).

   • According to Mohamed AI (2022)

     Excerpt In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa & its protective function against Fe2+ -induced oxidative hepatic injury were elucidated using in vitro, in silico, & ex vivo studies. The oxidative damage was induced in hepatic tissue by incubation with 0.1 mMolar ferrous sulfate (FeSO4) & then treated with different concentrations of crude extracts (ethyl acetate, ethanol, & aqueous) of HS flowers for 30 min at 37°C.

   • According to Liu JY (2006)

     Excerpt Dried flower Hibiscus sabdariffa L. HSE significantly reduced the liver damage including steatosis and fibrosis in a dose dependent manner.

3. 3

   Type II diabetes mellitus

   Plant part used: Flower Chalice.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to AMOS A (2022)

     Excerpt Recent studies have investigated the uses of Hibiscus sabdariffa to treat common chronic diseases.Its antihypertensive potential originates from the vasodilator activity, diuretic efficacy, functionality as an ACE inhibitor, adipocyte differentiation inhibitor, heart rate reduction ability, & anti-inflammatory mechanistics.The antihyperlipidemic effect is dose-dependent & stems from the antioxidative effect & the activation of AMPK through phosphorylation & also the inhibition of regulatory adipogenic transcription factors PPAR-γ, C/EBP-α & SREBP-1c which all together results in lipid-lowering effect.As an antihyperglycemic, HS serves as anti-insulin resistance by inhibition of the phosphorylation of IRS-1 beside the similar effect to gliptins.HS was proven to protect against neuroinflammation in microglial cell culture exposed to LPS by decreasing IL-1, IL-6, TNF-α expression, & the protective effect against glucotoxicity, improve memory function by inhibiting the formation of hyperphosphorylated tau proteins in the mouse brain. The databases PubMed, MEDLINE, Clinical Key, & CINAHL were searched for studies related to Hibiscus sabdariffa's compounds, antioxidative & anti-inflammatory features, mechanism of action on common chronic diseases including hypertension, hyperlipidemia, obesity, diabetes, & Alzheimer's disease.

   • According to Adeyemi D (2019)

     Excerpt This study evaluated the antidiabetic potentials of flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx (HSCE) on the pancreatic β-cells of experimental type I diabetic model rats. The study concluded that possible antidiabetic mechanism of Hibiscus sabdariffa in STZ diabetes is through induction of β-cell regeneration & its strong antioxidant potential.

   • According to Rosidah R (2014)

     Excerpt Then the test of Antidiabetic activity was conducted consisting of 11 treatment groups, ie groups of CMC suspension 0.5% as a negative control; Glibenclamide 0.65 mg/kg as a positive control; n-hexane extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg; ethyl acetate extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg & ethanol extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg & 600 mg / kg, which is respectively administered orally every day. The results of the statistical test (α = 0.05) showed that the extracts of n-hexane & ethyl acetate perform a real mean of difference on Glibenclamide, whereas the ethanol extract did not perform significant differences with Glibenclamide in lowering blood glucose levels on mice, which means that the ethanol extract can lower blood glucose levels of diabetic mice.

   • According to Abbas HA (2014)

     Excerpt This study aimed to study the antibacterial & antibiofilm activities of the ethanolic extract of Hibiscus sabdariffa & apple vinegar alone & in combination against one strong biofilm forming strain of each of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis & Klebsiella pneumoniae. The present study suggests the use of H sabdariffa extract & apple vinegar to treat diabetic foot infections as a natural inexpensive remedy.

   • According to Mohamed AI (2022)

     Excerpt In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa & its protective function against Fe2+ -induced oxidative hepatic injury were elucidated using in vitro, in silico, & ex vivo studies. Consumption of Hibiscus tea or juice may be a potential source for developing an anti-diabetic drug.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.