Hibiscus sabdariffa (Gwozèy-Djinen) : vertus médicinales en extraction alcoolique

Hibiscus sabdariffa (Gwozèy-Djinen, Groseille de guinée, Guinean redcurrant) — famille Malvacées.

Synonymes scientifiques : Hibiscus cruentus-Bertol.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 23 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 126 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Plaie infectée, incision, blessure, pied diabétique : Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae

   Partie usitée : Calice de Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Abbas HA (2014)

     Extrait This study aimed to study the antibacterial & antibiofilm activities of the ethanolic extract of Hibiscus sabdariffa & apple vinegar alone & in combination against one strong biofilm forming strain of each of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis & Klebsiella pneumoniae. coli at 8X MIC, P aeruginosa at 16X MIC, S epidermidis, P mirabilis & S aureus (32X MIC).

   • Selon AMOS A (2022)

     Extrait Recent studies have investigated the uses of Hibiscus sabdariffa to treat common chronic diseases.Its antihypertensive potential originates from the vasodilator activity, diuretic efficacy, functionality as an ACE inhibitor, adipocyte differentiation inhibitor, heart rate reduction ability, & anti-inflammatory mechanistics.The antihyperlipidemic effect is dose-dependent & stems from the antioxidative effect & the activation of AMPK through phosphorylation & also the inhibition of regulatory adipogenic transcription factors PPAR-γ, C/EBP-α & SREBP-1c which all together results in lipid-lowering effect.As an antihyperglycemic, HS serves as anti-insulin resistance by inhibition of the phosphorylation of IRS-1 beside the similar effect to gliptins.HS was proven to protect against neuroinflammation in microglial cell culture exposed to LPS by decreasing IL-1, IL-6, TNF-α expression, & the protective effect against glucotoxicity, improve memory function by inhibiting the formation of hyperphosphorylated tau proteins in the mouse brain. The databases PubMed, MEDLINE, Clinical Key, & CINAHL were searched for studies related to Hibiscus sabdariffa's compounds, antioxidative & anti-inflammatory features, mechanism of action on common chronic diseases including hypertension, hyperlipidemia, obesity, diabetes, & Alzheimer's disease.

   • Selon Adeyemi D (2019)

     Extrait This study evaluated the antidiabetic potentials of flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx (HSCE) on the pancreatic β-cells of experimental type I diabetic model rats. The study concluded that possible antidiabetic mechanism of Hibiscus sabdariffa in STZ diabetes is through induction of β-cell regeneration & its strong antioxidant potential.

   • Selon Rosidah R (2014)

     Extrait Then the test of Antidiabetic activity was conducted consisting of 11 treatment groups, ie groups of CMC suspension 0.5% as a negative control; Glibenclamide 0.65 mg/kg as a positive control; n-hexane extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg; ethyl acetate extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg & ethanol extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg & 600 mg / kg, which is respectively administered orally every day. The results of the statistical test (α = 0.05) showed that the extracts of n-hexane & ethyl acetate perform a real mean of difference on Glibenclamide, whereas the ethanol extract did not perform significant differences with Glibenclamide in lowering blood glucose levels on mice, which means that the ethanol extract can lower blood glucose levels of diabetic mice.

   • Selon Fullerton M (2011)

     Extrait Determination of antimicrobial activity of sorrel (Hibiscus sabdariffa) on Escherichia coli O157:H7 isolated from food, veterinary, & clinical samples.

2. 2

   Cancer : traitement adjuvant du carcinome hépatique & myélome multiple

   Partie usitée : Calice de Fleur.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Mahadevan N (2009)

     Extrait The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer & antioxidant properties. Hibiscus sabdariffa Linn.

   • Selon Lin HH (2007)

     Extrait Hibiscus sabdariffa Linné (Malvaceae), an attractive plant believed to be native to Africa, is cultivated in the Sudan and Eastern Taiwan. Using a set of apoptotic detection assays, they showed that HSE induced cytotoxicity and apoptosis of AGS cells in a concentration-dependent manner but is ineffective in Chang liver cells.

   • Selon Famurewa AC (2019)

     Extrait By contrast, ZD administration attenuated & restored the markers of liver injury, hepatic antioxidant enzymes & lipid peroxidation near to control, while histopathological alterations were ameliorated compared to the MTX group. MTX induced prominent oxidative hepatotoxicity demonstrated by significant (p < .01) increases in serum liver enzymes & bilirubin, while protein profile was markedly reduced (p < .05).

   • Selon Mohamed AI (2022)

     Extrait In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa & its protective function against Fe2+ -induced oxidative hepatic injury were elucidated using in vitro, in silico, & ex vivo studies. The oxidative damage was induced in hepatic tissue by incubation with 0.1 mMolar ferrous sulfate (FeSO4) & then treated with different concentrations of crude extracts (ethyl acetate, ethanol, & aqueous) of HS flowers for 30 min at 37°C.

   • Selon Liu JY (2006)

     Extrait Dried flower Hibiscus sabdariffa L. HSE significantly reduced the liver damage including steatosis and fibrosis in a dose dependent manner.

3. 3

   Diabète mellitus de type II

   Partie usitée : Calice de Fleur. Profil pharmacologique documenté : Glibenclamide-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon AMOS A (2022)

     Extrait Recent studies have investigated the uses of Hibiscus sabdariffa to treat common chronic diseases.Its antihypertensive potential originates from the vasodilator activity, diuretic efficacy, functionality as an ACE inhibitor, adipocyte differentiation inhibitor, heart rate reduction ability, & anti-inflammatory mechanistics.The antihyperlipidemic effect is dose-dependent & stems from the antioxidative effect & the activation of AMPK through phosphorylation & also the inhibition of regulatory adipogenic transcription factors PPAR-γ, C/EBP-α & SREBP-1c which all together results in lipid-lowering effect.As an antihyperglycemic, HS serves as anti-insulin resistance by inhibition of the phosphorylation of IRS-1 beside the similar effect to gliptins.HS was proven to protect against neuroinflammation in microglial cell culture exposed to LPS by decreasing IL-1, IL-6, TNF-α expression, & the protective effect against glucotoxicity, improve memory function by inhibiting the formation of hyperphosphorylated tau proteins in the mouse brain. The databases PubMed, MEDLINE, Clinical Key, & CINAHL were searched for studies related to Hibiscus sabdariffa's compounds, antioxidative & anti-inflammatory features, mechanism of action on common chronic diseases including hypertension, hyperlipidemia, obesity, diabetes, & Alzheimer's disease.

   • Selon Adeyemi D (2019)

     Extrait This study evaluated the antidiabetic potentials of flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx (HSCE) on the pancreatic β-cells of experimental type I diabetic model rats. The study concluded that possible antidiabetic mechanism of Hibiscus sabdariffa in STZ diabetes is through induction of β-cell regeneration & its strong antioxidant potential.

   • Selon Rosidah R (2014)

     Extrait Then the test of Antidiabetic activity was conducted consisting of 11 treatment groups, ie groups of CMC suspension 0.5% as a negative control; Glibenclamide 0.65 mg/kg as a positive control; n-hexane extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg; ethyl acetate extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg and 600 mg / kg & ethanol extracts of roselle calyces dose of 200 mg / kg, 400 mg / kg & 600 mg / kg, which is respectively administered orally every day. The results of the statistical test (α = 0.05) showed that the extracts of n-hexane & ethyl acetate perform a real mean of difference on Glibenclamide, whereas the ethanol extract did not perform significant differences with Glibenclamide in lowering blood glucose levels on mice, which means that the ethanol extract can lower blood glucose levels of diabetic mice.

   • Selon Abbas HA (2014)

     Extrait This study aimed to study the antibacterial & antibiofilm activities of the ethanolic extract of Hibiscus sabdariffa & apple vinegar alone & in combination against one strong biofilm forming strain of each of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis & Klebsiella pneumoniae. The present study suggests the use of H sabdariffa extract & apple vinegar to treat diabetic foot infections as a natural inexpensive remedy.

   • Selon Mohamed AI (2022)

     Extrait In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa & its protective function against Fe2+ -induced oxidative hepatic injury were elucidated using in vitro, in silico, & ex vivo studies. Consumption of Hibiscus tea or juice may be a potential source for developing an anti-diabetic drug.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.