Hibiscus syriacus (Syrian Rose) : medicinal properties in alcoholic extraction

Hibiscus syriacus (Syrian Rose, Rose de Syrie) — family Malvacées.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 10 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 59 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for colorectal carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Xu XY (2022)

     Excerpt In our previous study, Hibiscus syriacus leaf tissue was successfully cultivated in an optimized callus culture system, & subsequently extracted with 70% ethanol to prepare HS callus extract (HCE). The previous study suggested that the callus culture is useful method for obtaining the anti-inflammatory ingredients from HS Purpose In the present study, we aimed to investigate the effect of HCE on the colorectal cancer (CRC) & its underlying mechanism of action using HT-29 cells & thymus-deficient mice bearing HT-29 xenografts.

   • According to Cheng Y (2008)

     Excerpt syriacus (HS-AE) exhibited a better cytotoxic effect on lung cancer cells than its methanol extract (HS-ME) or water extract (HS-WE). These results indicate that HS-AE exerts significant & dose-dependent antiproliferative effects on cancer cells in vitro & in vivo, which prompts us to further evaluate and elucidate the bioactive component(s) of HS.

   • According to CHAO Hh (2025)

     Excerpt Hibiscus syriacus L. Cells exposed to Ang II were pretreated with HS extracts, & assays were performed to assess cell viability, reactive oxygen species (ROS) generation, protein synthesis, & secretion of inflammatory mediators, including tumor necrosis factor-alpha, interleukin 1β (IL-1β), & interleukin 6 (IL-6), as well as chemokine (CCL20) & HF-related biomarkers, such as brain natriuretic peptide (BNP) & endothelin-1.

   • According to Hsu R (2015)

     Excerpt Methods: This study screened Chinese herb Hibiscus syriacus extracts & identified a novel anti-cancer drug for patients with ER-negative breast cancer. Result: We found several triterpenoids including betulin (K02) & its derivatives (K03, K04, & K06) from HS inhibited human triple-negative breast cancer cell viability & migration but revealed smaller cytotoxic effects on normal mammalian epithelial cells.

   • According to Yoo ID (1998)

     Excerpt Three new naphthalene, designated as syriacusins A-C, were isolated from the root bark of Hibiscus syriacus. The first compound also showed cytotoxicity against some human cancer cell lines with an ED50 of 1.5-2.4 micrograms,.

2. 2

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to KIM HN (2018)

     Excerpt In this study, we evaluated the anti-inflammatory effect of 70% ethanol extracts from the root of HS (RHS-E70) & elucidated the potential signaling pathway in LPS-stimulated RAW264.7 cells. These results indicate that RHS-E70 may exert anti-inflammatory activity by inhibiting NF-κB & MAPK/ATF2 signaling.

   • According to Lee CM (2023)

     Excerpt This study aimed to investigate the anti-inflammatory effect of HSE in LPS-stimulated Raw 264.7 cells. Hibiscus syriacus L.

   • According to Punasiya R (2014)

     Excerpt It is used in tradition system of medicine & exibits diuretic, expectorant, stomachic, ophthalmic, antipyretic, anti-Inflammatory activity, antioxidant, demulcent, emollient, febrifuge, haemostatic & antifungal agent. Hibiscus syriacus Linn.

   • According to Zhang RR (2020)

     Excerpt The flower of Hibiscus syriacus Linn is a well-known traditional Chinese medicine (TCM) & health food in China, which has been used to treat dysentery, vaginal discharge, & hemorrhoids. In this study, five polyphenols (compounds 1-5) & five fatty acids (compounds 6-10) were isolated from the ethanol extract of the flower of HS.

   • According to KOYUNCU M (2024)

     Excerpt Studies have shown that Hibiscus species have anti-inflammatory, antibacterial, antifertility, antifungal, antioxidative, antihypertensive, & hypoglycaemic effects. The compounds with the highest ratios determined in the flower, seeds, leaves, & buds of Hibiscus syriacus L.

3. 3

   Oxidative stress

   Plant part used: Flower.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Molagoda I.M.N (2020)

     Excerpt Collectively, our results suggested that, under H2O2-mediated oxidative stress conditions, PS sustained a normal level of mitochondrial membrane potential and ROS generation in HaCaT keratinocytes by activating the Nrf2/HO-1 axis, exerting cytoprotective effects against oxidative stress. In this study, we evaluated the cytoprotective effect of PS against H2O2-induced oxidative stress in HaCaT keratinocytes.

   • According to Rassem HHA (2022)

     Excerpt Scanning electron microscopy (SEM) was used to investigate the surface morphologies of raw powdered hibiscus flowers (not exposed to any pretreatment) & pretreated powdered hibiscus flowers (exposed to methanol absorption for 60 minutes prior to extraction). Therefore, the MAHD method is well-suited to extracting EOs from hibiscus flowers, & the resulting oil has the potential to provide significant therapeutic advantages,.

   • According to JIN YQ (2019)

     Excerpt JIN YQ et al, Composition analysis & antioxidant activity of polysaccharide from Hibiscus syriacus, Zhongguoo Zhong Yao Za Zhi, ;44(9):1822-8, 2019-Abstract; The flower of Hibiscus syriacus has good ornamental & edible-medicinal values. Among the tested varieties, polysaccharides of pink multiple petals flower & white multiple petals flower had the same molecular masses & monosaccharides composition, but the antioxidant activity of the polysaccharides of pink multiple petals flower was higher than that of the white flowers.

   • According to Park Y (2022)

     Excerpt As the national flower of Korea, the Hibiscus syriacus L. The petals produced high quantities of glucose, sucrose, & fumaric acid, with the highest antioxidant activity among the four units.

   • According to Punasiya R (2014)

     Excerpt Hibiscus syriacus Linn. It is used in tradition system of medicine & exibits diuretic, expectorant, stomachic, ophthalmic, antipyretic, anti-Inflammatory activity, antioxidant, demulcent, emollient, febrifuge, haemostatic & antifungal agent.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.