Holmskioldia sanguinea : medicinal properties in alcoholic extraction
Holmskioldia sanguinea (Chapo chinwa -Chapeau chinois) — family Verbénacées.
Scientific synonyms : Holmskioldia rubra-Pers, Hastingia coccinea-Sm, H scandens-Roxb, Platinum rubrum-A Juss.
This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 2 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 16 scientific references for this species (full detail in the application).
Therapeutic indications in alcoholic extraction:
Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).
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Cancer: adjuvant treatment for lymphoma
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to PAL M (2017)
Excerpt Protective effect of Holmskioldia sanguinea leaf ethanolic extract has been investigated against Ehrlich ascites carcinoma (EAC) & Dalton’s ascites lymphoma (DAL) in Swiss albino mice to evaluate the possible mechanism of action. Holmskioldia sanguinea is a large climbing shrub found in the Himalayas at an altitude of 5,000 ft & preliminary investigation showed the excellent yield of andrographolide & subjected for the anticancer activity.
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According to SATI R (2021)
Excerpt Herb's anti-tumor & anti-cancer properties have generated significant interest. Holmskioldia sanguinea Retz.
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According to PAL M (2017)
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Bacterial infection: Escherichia coli, Staphylococcus aureus
Scientific references (short excerpts)
Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.
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According to Ajaib M (2013)
Excerpt In the present study, the various extracts of the plant Holmskioldia sanguinea Retz., were studied for their antioxidant & antimicrobial activities.
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According to Ajaib M (2013)
Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.
Evolution of this plant record
Under the CTA · public change history
~2 indications corrected · −1 indication · +7 references · ~8 references corrected · −1 reference
Counts and domains only: indication labels and synergy names are not listed here (open the in-app plant file). Full bibliographic texts for new, corrected, or removed references expand below.
+7 references — show text
SAKR W et al, Establishment of an In vitro Rapid Direct Regeneration Protocol for Holmskioldia sanguinea Rare Flowering Plant Production, Agric & Food Sci, 2015-Abstract: This study was carried out in the Plant Tissue Culture Laboratory, Horticulture Research Institute, Agriculture Research Center, Ministry of Agriculture, during the period from 2011 to 2014. An efficient direct shoot regeneration micropropagation protocol has been established successfully for commercial in vitro propagation of Holmskioldia sanguinea, a rare plant with ornamental & medicinal values. The optimized sterilizat…
AddedChaudhuri PK et al Antiinflammatory Activity of Holmskioldia sanguinea Extracts. Phytother Res, 10:357-8. 1996-Abstract: A carrageenin-induced oedema model was investigated to compare and elucidate the antiinflammatory effects of three fractions (CHCl3, n-BuOH & H2O) from the aerial parts of Holmskioldia sanguinea. The H2O (20 & 40 mg) &dn-BuOH (200 mg) fractions were found to be effective compared with standard hydrocortisone. The effective dose & lethal dose (LD50) value indicated that the extract was non-toxic.
AddedSahney M et al, Wood anatomy of Holmskioldia sanguinea Retz: its adaptive & ecological significance. Taiwania 2017; 62(2):139-43.
AddedPal M et al, new source of andrographolide having potential biological activities. Jl of Bioequivalence & Bioavailability 2018; 10:65.
AddedYadava RN et al, The Antibacterial Activity of Natural-Derived Flavonoids. Current Topics in Med Chem, 22(12), 1009-19, 2022-Abstract: A new flavone glycoside was isolated from ethanolic extract of stem parts of Holmskioldia sanguinea Retz. Its structure was characterized as 3,4′-dihydroxy-5,7-dimethoxyflavone-3-O-β-D-galactopyranosyl (1→4)-O-β-D-arabi-nopyranosyl-4′-O-α-L-rhamnopyranoside (1) by colour reactions, chemical degradation & spectroscopic analysis. Antibacterial activity of compound 1 was evaluated against various Gram positive & Gram-negative bacteria showing a significant effect.
AddedSATI R et al, Antidiabetic Activity of Methanolic Leaf Extract of Holmskioldia Sanguinea in Streptozotocin-Nicotinamide Induced Type 2 Diabetic Rats, Jl of Diabetes & Metabolism, 13:7, 2022-Abstract: Holmskioldia sanguinea is a Sub-Himalayan plant that has been cultivated in the Americas, Europe, Indo-China, Asia-Pacific, & Southern Africa. The present study seeks to evaluate the methanolic leaf extract of S (MLEHS) for its anti-diabetic effect against streptozotocin–nicotinamide induced type 2 diabetic models in albino wistar rats. Phytochemical screening, oral glucose tolerance test and a…
AddedChaudhari PK et al, Andrographolide & Other Constituents of Holmskioldia Sanguinea. Indian jl of Chem, 38B:632-4. 1999-Abstract: A new compound 27-methylnonaeicosanol 1 together with known lipids, lIiterpenoids, tlavonoids, bioacti ve andrographolide & neoandrographol ide have been isolated from Holmskioldia sanguinea & identi fi ed by thei r spectral & chemical study. This is the second natural occurrence of andrographolide and neoandrographolide, & their first occurrence from HS is of chemotaxollomic importance.
AddedSATI R et al, PHYTOPHARMACOLOGY OF HOLMSKIOLDIA SANGUINEA RETZ.: A REVIEW, Inter Res Jl of Pharm,, 2021-Abstract: Holmskioldia sanguinea Retz. is a Sub-Himalayan plant that has been cultivated in the Americas, Europe, Indo-China, Asia-Pacific, & Southern Africa. It has been used traditionally to treat rheumatism & rheumatoid arthritis, dysentery, headaches, hypertension, boils, blain, ulcers, & gynaecological problems, as well as a blood purifying concoction. The botanical description of the plant, its phytochemical constituents, & its pharmacological activities are discussed, with an empha…
CorrectedYadava RN et al, Allelopathic Effects of Leaves & Stems Extract of Holmskioldia sanguinea Retz. European jl Of Pharmaceut & Med Res, 5(11):619-21. 2018-Abdtract:
CorrectedChaudhuri PK et al, Phytotoxic & Antimicrobial Constituents of Bacopa Monnieri & Holmskioldia sanguinea. Phytother Res, 18 (2):114-7. 2004-Abstract: The phytochemicals betulinic acid (1), wogonin (2) & oroxindin (3) isolated from the aerial parts of Bacopa monnieri & Holmskioldia sanguinea showed significant antifungal activity against the two fungi Alternaria alternata & Fusarium fusiformis. Inhibition of root growth germination of wheat seeds was observed for all three compounds which showed 100% inhibition at 10 micro g/mL. Compounds (1) & (2) showed potent inhibition of Alternaria alter…
CorrectedAjaib M et al, Antioxidant & Antimicrobial Activities of an Ethnobotanically Important Plant Holmskioldia sanguinea Retz. of District Kotli, Azad Jammu & Kashmir. Pharmacology-online, 1:135-43. 2013-Abstract: In the present study, the various extracts of the plant Holmskioldia sanguinea Retz., were studied for their antioxidant & antimicrobial activities. Antioxidant potential of these extracts was evaluated by four methods: 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, total antioxidant activity, ferric reducing antioxidant power (FRAP) assay & ferric thiocyanate assay…
CorrectedPAL M et al, Antihepatotoxic effect of holmskioldia Sanguinea, Inter JL of Pharm & Pharmaceut Sci, 3:418-20, 2011-Abstract: The present study seeks to evaluate the alcoholic extract of aerial part of H.Sanguinea for its anti-hepatotoxic effect against carbon tetrachloride (CCI 4) induced hepatic damage in rats & phytochemical analysis.The phytochemical results depicted the presence of alkaloids, flavonoids, tannins, terpenoids, carbohydrate, glycosides & phenols.The activity was evaluated by using some biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), alkaline pho…
CorrectedPAL M et al, Protective Effect of the Standardized Extract of Holmskioldia sanguinea on Tumor Bearing Mice, Inter Jl of Biotechnol & Bio prospect, 11:08, 2017-Abstract: Holmskioldia sanguinea is a large climbing shrub found in the Himalayas at an altitude of 5,000 ft & preliminary investigation showed the excellent yield of andrographolide & subjected for the anticancer activity. Protective effect of Holmskioldia sanguinea leaf ethanolic extract has been investigated against Ehrlich ascites carcinoma (EAC) & Dalton’s ascites lymphoma (DAL) in Swiss albino mice to evaluate the possible mecha…
CorrectedHelfrich E et al, Iridoid glycosides & phenolic glycosides from Holmskioldia sanguinea. Phytochem, 50:619-27. 1999-Abstract: four new iridoids, 6-O-α-l-(2 ″-O-trans-cinnamoyl) rhamnopyranosylcatalpol, 6-O-α-l-(3 ″-O-trans-cinnamoyl) rhamnopyrano sylcatalpol, 6-O-α-l-(4 ″-O-trans-cinnamoyl) rhamno-pyranosyl-catalpol & 6-O-α-l-(4 ″-O-cis-feruloyl) rhamnopyranosylcatalpol, along with three known monoacyl rhamno-pyranosyl-catalpol derivatives have been isolated from the aerial parts of Holmskioldia sanguinea. Catalpol was identified by GC & GC–MS analysis. Three known phenolic glycosides, isola…
CorrectedPAL M et al, Antiinflammatory Activity of Holmskioldia sanguinea Extracts, Phytother Res, 1996-Abstract: A carrageenin‐induced oedema model was investigated to compare & elucidate the antiinflammatory effects of three fractions (CHCl3, n‐BuOH & H2O) from the aerial parts of Holmskioldia sanguinea. The H2O (20 & 40 mg) & n‐BuOH (200 mg) fractions were found to be effective compared with standard hydrocortisone. The effective dose & lethal dose (LD50) value indicated that the extract was non‐toxic.
CorrectedYadava RN et al, Antibacterial Activity of a New Flavone Glycoside from the Stems of Holmskioldia sanguinea Retz. Asian J of Chem, 2019; 31(8):1815-8-Abstract: A new flavone glycoside was isolated from ethanolic extract of stem parts of Holmskioldia sanguinea Retz. Its structure was characterized as 3,4′-dihydroxy-5,7-dimethoxyflavone-3-O-β-D-galactopyranosyl (1→4)-O-β-D-arabinopyranosyl-4′-O-α-L-rhamnopyranoside (1) by colour reactions, chemical degradation & spectroscopic analysis. Antibacterial activity of compound 1 was evaluated against various Gram positive & Gram-negative bacteria sh…
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