Humulus lupulus (Hops) : medicinal properties in alcoholic extraction

Humulus lupulus (Hops, Houblon) — family Cannabacées.

Scientific synonyms : Hu Humuulus cordifolius Miiq, Hvulgaris Gilib., Lupulus amarus Gilib, L communis G.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 262 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Bacterial infection: Enterococcus faecalis & Staphylococcus aureus – Methicillin-resistant (MRSA)

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Flieger J (2024)

     Excerpt Only the modification of IONPs with DMSO extract improved their antibacterial properties against Gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Bacillus cereus) from a MIC value of 2.5-10 mg/mL to 0.313-1.25 mg/mL. The aim of this work is to synthesize IONPs using a mixed method, i.e., chemical co-precipitation combined with biogenic surface modification, using extracts from spent hops (Humulus lupulus L.) obtained as waste product from supercritical carbon dioxide hop extraction.

   • According to Wendakoon CD (2018)

     Excerpt Wendakoon CD et al, Hops (Humulus lupulus) strobile extract & its major components show strong antibacterial activity against methicillin–resistant Staphylococcus aureus.

   • According to Di Sotto A (2018)

     Excerpt A hydroalcoholic extract from female inflorescences of Humulus lupulus L. Since HOP extract was able to restore the reducing conditions of infected cells, by increasing glutathione content, its antiviral activity might be also due to an interference with redox-sensitive pathways required for viral replication.

   • According to Natarajan P (n.d.)

     Excerpt The research reported here deals with co-action of the hop (Humulus lupulus)-derived anti-bacterial compounds, lupulone & xanthohumol, with several antibiotics. An antibacterial cream with lupulone, neomycin & polymyxin B sulfate was prepared & showed co-action.

   • According to Percaccio E (2023)

     Excerpt In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) & the cones of Humulus lupulus L. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating & antiviral activities, likely due to the peculiar Phyto complexes of both ECP & HOP, & often potentiated the effect of the single extracts.

2. 2

   Viræmia: influenza A virus, strain H1N1 (PR8)

   Plant part used: Flower. Mentioned synergistic association: Echinacea purpurea-parties aériennes.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Percaccio E (2023)

     Excerpt Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant & inflammatory stimuli & its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) & the cones of Humulus lupulus L.

   • According to Di Sotto A (2018)

     Excerpt In conclusion, our results highlighted anti-influenza & antioxidant properties of HOP extract, which encourage further in vivo studies to evaluate its possible application. A hydroalcoholic extract from female inflorescences of Humulus lupulus L.

   • According to Sun S (2012)

     Excerpt The biological activities of hops compound such as antibacterial, antifungal, cardioprotective, antioxidant, anti-inflammatory & anticancer are reviewed & the recent effects of hop bittering derivatives on beer-related microbial activity are also presented. In recent years, a wide variety of bioactive compounds have been reported to be present in female flowers.

   • According to Gomez da Silva R (2021)

     Excerpt The bioactivity prediction of the flavonoids was evaluated in silico through in house Active-IT software & PASS online which indicated potential activity as antitumoral, cytotoxic, anti-inflammatory, antiparasitic, antimicrobial, antiviral & others. Ethanolic (EB) extract & hexanic (SH) & hydromethanolic (SEM) sub-extracts of Humulus lupulus leaves were submitted to cytotoxicity evaluation & to phytochemical methods.

   • According to Karabin M (2016)

     Excerpt Although female cones of the hop plant (Humulus lupulus) are known primarily as raw material supplying characteristic bitterness & aroma to beer, their equally significant health-promoting effects have been known to mankind for several thousand years & hop is a plant traditionally utilized in folk medicine. Hop oils & resins are well known for their sedative & other neuropharmacological properties, but in addition, these compounds exhibit antibacterial & antifungal effects.

3. 3

   Cancer: adjuvant treatment for glioblastoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Sun S (2012)

     Excerpt The biological activities of hops compound such as antibacterial, antifungal, cardioprotective, antioxidant, anti-inflammatory & anticancer are reviewed & the recent effects of hop bittering derivatives on beer-related microbial activity are also presented.

   • According to Miranda CL (1999)

     Excerpt Six flavonoids [xanthohumol (XN), 2′,4′,6′,4-tetrahydroxy-3′-prenyl-chalcone (TP); 2′,4′,6′,4-tetrahydroxy-3′-geranylchalcone (TG); dehydro-Cyclo xanthohumol (DX); dehydro-cyclo-xanthohumol hydrate (DH); & is xanthohumol (IX)] from Humulus lupulus were tested for their antiproliferative activity in human breast cancer (MCF-7), colon cancer (HT-29) & ovarian cancer (A-2780) cells in vitro. As antiproliferative agents, XN (chalcone) & IX (flavanone isomer of XN) may have potential chemopreventive activity against breast & ovarian cancer in humans.

   • According to Yilmazer M (2001)

     Excerpt Xanthohumol (XN) is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). Recent studies have suggested that XN may have potential cancer-chemopreventive activity, but little is known about its metabolism.

   • According to HO YC (2008)

     Excerpt Besides, the inhibitory effects of xanthohumol on human hepatocellular carcinoma cell lines were attributed to apoptosis as indicated in the results of flow cytometry, fluorescent nuclear staining & electrophoresis of oligonucleosomal DNA fragments. Hop xanthohumol was more efficient in the growth inhibition of hepatocellular carcinoma cell lines than the flavonoids silibinin & naringin from thistle & citrus.

   • According to Delmulle L (2008)

     Excerpt Xanthohumol (X), isoxanthohumol (IX), 8-prenylnaringenin (8PN) & 6-prenylnaringenin (6PN), prenylflavonoids from hop (Humulus lupulus L.), were investigated for their cytotoxicity & the mechanism by which they exert cell death when incubated with prostate cancer cell lines PC-3 & DU145. Therefore, IX, 8PN & 6PN appear to be promising candidates for further investigation in prostate anticancer therapy.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.