Humulus lupulus (Houblon) : vertus médicinales en extraction alcoolique

Humulus lupulus (Houblon, Hops) — famille Cannabacées.

Synonymes scientifiques : Hu Humuulus cordifolius Miiq, Hvulgaris Gilib., Lupulus amarus Gilib, L communis G.

Sources externes reconnues associées à cette monographie : Pharmacopée française.

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 9 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 262 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Infection bacterienne : Enterococcus faecalis & Staphylococcus aureus -Methicillin-Resistant (MRSA)

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Flieger J (2024)

     Extrait Only the modification of IONPs with DMSO extract improved their antibacterial properties against Gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Bacillus cereus) from a MIC value of 2.5-10 mg/mL to 0.313-1.25 mg/mL. The aim of this work is to synthesize IONPs using a mixed method, i.e., chemical co-precipitation combined with biogenic surface modification, using extracts from spent hops (Humulus lupulus L.) obtained as waste product from supercritical carbon dioxide hop extraction.

   • Selon Wendakoon CD (2018)

     Extrait Wendakoon CD et al, Hops (Humulus lupulus) strobile extract & its major components show strong antibacterial activity against methicillin–resistant Staphylococcus aureus.

   • Selon Di Sotto A (2018)

     Extrait A hydroalcoholic extract from female inflorescences of Humulus lupulus L. Since HOP extract was able to restore the reducing conditions of infected cells, by increasing glutathione content, its antiviral activity might be also due to an interference with redox-sensitive pathways required for viral replication.

   • Selon Natarajan P (s.d.)

     Extrait The research reported here deals with co-action of the hop (Humulus lupulus)-derived anti-bacterial compounds, lupulone & xanthohumol, with several antibiotics. An antibacterial cream with lupulone, neomycin & polymyxin B sulfate was prepared & showed co-action.

   • Selon Percaccio E (2023)

     Extrait In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) & the cones of Humulus lupulus L. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating & antiviral activities, likely due to the peculiar Phyto complexes of both ECP & HOP, & often potentiated the effect of the single extracts.

2. 2

   Viremie : virus influenza A virus strain H1N1 (PR8)

   Partie usitée : Fleur. Association synergique mentionnée : Echinacea purpurea-parties aériennes.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Percaccio E (2023)

     Extrait Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant & inflammatory stimuli & its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) & the cones of Humulus lupulus L.

   • Selon Di Sotto A (2018)

     Extrait In conclusion, our results highlighted anti-influenza & antioxidant properties of HOP extract, which encourage further in vivo studies to evaluate its possible application. A hydroalcoholic extract from female inflorescences of Humulus lupulus L.

   • Selon Sun S (2012)

     Extrait The biological activities of hops compound such as antibacterial, antifungal, cardioprotective, antioxidant, anti-inflammatory & anticancer are reviewed & the recent effects of hop bittering derivatives on beer-related microbial activity are also presented. In recent years, a wide variety of bioactive compounds have been reported to be present in female flowers.

   • Selon Gomez da Silva R (2021)

     Extrait The bioactivity prediction of the flavonoids was evaluated in silico through in house Active-IT software & PASS online which indicated potential activity as antitumoral, cytotoxic, anti-inflammatory, antiparasitic, antimicrobial, antiviral & others. Ethanolic (EB) extract & hexanic (SH) & hydromethanolic (SEM) sub-extracts of Humulus lupulus leaves were submitted to cytotoxicity evaluation & to phytochemical methods.

   • Selon Karabin M (2016)

     Extrait Although female cones of the hop plant (Humulus lupulus) are known primarily as raw material supplying characteristic bitterness & aroma to beer, their equally significant health-promoting effects have been known to mankind for several thousand years & hop is a plant traditionally utilized in folk medicine. Hop oils & resins are well known for their sedative & other neuropharmacological properties, but in addition, these compounds exhibit antibacterial & antifungal effects.

3. 3

   Cancer : traitement adjuvant du glioblastome

   Partie usitée : Feuille.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Sun S (2012)

     Extrait The biological activities of hops compound such as antibacterial, antifungal, cardioprotective, antioxidant, anti-inflammatory & anticancer are reviewed & the recent effects of hop bittering derivatives on beer-related microbial activity are also presented.

   • Selon Miranda CL (1999)

     Extrait Six flavonoids [xanthohumol (XN), 2′,4′,6′,4-tetrahydroxy-3′-prenyl-chalcone (TP); 2′,4′,6′,4-tetrahydroxy-3′-geranylchalcone (TG); dehydro-Cyclo xanthohumol (DX); dehydro-cyclo-xanthohumol hydrate (DH); & is xanthohumol (IX)] from Humulus lupulus were tested for their antiproliferative activity in human breast cancer (MCF-7), colon cancer (HT-29) & ovarian cancer (A-2780) cells in vitro. As antiproliferative agents, XN (chalcone) & IX (flavanone isomer of XN) may have potential chemopreventive activity against breast & ovarian cancer in humans.

   • Selon Yilmazer M (2001)

     Extrait Xanthohumol (XN) is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). Recent studies have suggested that XN may have potential cancer-chemopreventive activity, but little is known about its metabolism.

   • Selon HO YC (2008)

     Extrait Besides, the inhibitory effects of xanthohumol on human hepatocellular carcinoma cell lines were attributed to apoptosis as indicated in the results of flow cytometry, fluorescent nuclear staining & electrophoresis of oligonucleosomal DNA fragments. Hop xanthohumol was more efficient in the growth inhibition of hepatocellular carcinoma cell lines than the flavonoids silibinin & naringin from thistle & citrus.

   • Selon Delmulle L (2008)

     Extrait Xanthohumol (X), isoxanthohumol (IX), 8-prenylnaringenin (8PN) & 6-prenylnaringenin (6PN), prenylflavonoids from hop (Humulus lupulus L.), were investigated for their cytotoxicity & the mechanism by which they exert cell death when incubated with prostate cancer cell lines PC-3 & DU145. Therefore, IX, 8PN & 6PN appear to be promising candidates for further investigation in prostate anticancer therapy.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.