Ixora coccinea (Ixora) : medicinal properties in alcoholic extraction

Ixora coccinea (Ixora) — family Rubiacées.

Scientific synonyms : Ixora bandhuca Roxb., I eekhautii Gentil, I fraseri-Gentil, I grandiflora Ker Gawl., I lutea Hutch., I montana Gentil, I morsei Gentil, I obovata B.Heyne ex Roth, I propinqua R.Br. ex G.Don, I purpurea Fisch. ex Loudon, I thomeana (K.Schum.) G.Taylor, Pavetta bandhuca Miq., P coccinea (L.) Blume.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 17 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 102 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for breast cancer

   Plant part used: flower. Mentioned synergistic association: association synergique avec VITIS VINIFERA –L (Semence), association synergique avec PIPER LONGUM-L (Racine).

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Urolagin DK (2018)

     Excerpt Here, we investigated the anti-cancer effects of 3 drug extracts-Vitis vinifera-Grape seeds (GSE), Ixora coccinea flower & Piper longum root extract against breast cancer treatment. The percentage inhibition of V vinifera (10–320 µg/ml), I coccinea (10–320 µg/ml) & P longum (10–320 µg/ml) treatment of cells resulted in 10–90%, 6-53% & 14-90% growth inhibition respectively.

   • According to Sumathy H (2012)

     Excerpt To investigate the presence of various phytochemicals from the flowers extracts of Ixora coccinea belonging to the Rubiaceae family. Further study on the in vitro anticancer activity was extended to elucidate the molecular Mechanism of action of the EA extract.

   • According to Sajini RJ (2024)

     Excerpt ixora coccinea is a medicinal plant with many active constituents that are responsible for wound healing & have anticancer properties. Both studies involved in the DNA damage study against malignant melanoma cell lines showed the cleavage of apoptotic cancer cells, which was detected using a fluorescence microscope.

   • According to Saravanan Periasamy (2011)

     Excerpt The anticancer activity of the leaves of Ixora coccinia (Rubiaceae) was found to be due principally to the known alkaloid, camptothecin.

   • According to LEE CL (2010)

     Excerpt Two novel derivatized peptides, designated as ixorapeptide I (1) & ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using Bioassay-guided fractionation. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC (50) value of 3.36 μg/mL, & compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation & elastase release with IC (50) values of 0.21 and 0.27 μg/mL, respectively.

2. 2

   Dermatophytosis: Trichophyton mentagrophytes

   Plant part used: leaf.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ma M Faye L Carvajal (2023)

     Excerpt This study was conducted to determine the Bio-Efficacy of Santan (Ixora coccinea) Leaf Extract against Trichophyton mentagrophytes: An Antifungal Susceptibility Testing. The study used the experimental research design and subjected the PDA cultures of Trichophyton mentagrophytes into sterile distilled water as a negative control, Ketoconazole as the positive control, & three (3) concentrations of IC leaf extract in three (3) trials.

   • According to Davendran A (2020)

     Excerpt Ixora Coccinea Linn., belongs to the family Rubiaceae, which is typically known as Red Ixora or jungle of geranium, it is an evergreen shrub which is habited in India. In this review studies the traditional and Pharmacological uses of Ixora Coccinea.

   • According to Nalvothula R (2014)

     Excerpt This study aims to analyse aqueous, ethanolic & methanolic extracts of flowers of Ixora coccinea for the presence of various phytochemicals & synthesised silver nanoparticles using the aqueous extract of IC flowers & also checked the antimicrobial activity, TLC studies using both the extracts.

   • According to Chatterjee P (2014)

     Excerpt This paper represents the antifungal property of the crude leaf extract of Ixora coccinea against Botrytis cinerea. As the result was positive, we performed sequential solvent partitioning of the crude leaf extract of IC to locate which fraction actually carries the antifungal one.

   • According to Poornima S (2014)

     Excerpt the antibacterial property of leaves of different colored varieties of Ixora coccinea Linn (Family: Rubiaceae) was studied against drug-resistant pathogenic bacteria by agar well diffusion & broth dilution methods. Presence of phytochemicals such as alkaloids, phenols, steroids, saponins, and flavonoids were observed in the plant extracts which have antibacterial activity & can be used for medicinal purpose.

3. 3

   Plant fungus: Botrytis cinerea

   Plant part used: Pest control and veterinary products.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chatterjee P (2014)

     Excerpt This paper represents the antifungal property of the crude leaf extract of Ixora coccinea against Botrytis cinerea. Diethyl ether fraction was found to contain some bioactive phytochemical(s) that can be of ecofriendly use to control the spreading of Botrytis cinerea.

   • According to Davendran A (2020)

     Excerpt Ixora Coccinea Linn., belongs to the family Rubiaceae, which is typically known as Red Ixora or jungle of geranium, it is an evergreen shrub which is habited in India. In this review studies the traditional and Pharmacological uses of Ixora Coccinea.

   • According to Nalvothula R (2014)

     Excerpt This study aims to analyse aqueous, ethanolic & methanolic extracts of flowers of Ixora coccinea for the presence of various phytochemicals & synthesised silver nanoparticles using the aqueous extract of IC flowers & also checked the antimicrobial activity, TLC studies using both the extracts.

   • According to Ma M Faye L Carvajal (2023)

     Excerpt This study was conducted to determine the Bio-Efficacy of Santan (Ixora coccinea) Leaf Extract against Trichophyton mentagrophytes: An Antifungal Susceptibility Testing. Although, the IC leaf extract is not as effective as the antifungal agent for T mentagrophytes used for positive control, which is Ketoconazole.

   • According to Poornima S (2014)

     Excerpt the antibacterial property of leaves of different colored varieties of Ixora coccinea Linn (Family: Rubiaceae) was studied against drug-resistant pathogenic bacteria by agar well diffusion & broth dilution methods. Presence of phytochemicals such as alkaloids, phenols, steroids, saponins, and flavonoids were observed in the plant extracts which have antibacterial activity & can be used for medicinal purpose.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.