Jatropha gossypifolia (Mèdsiyen-wouj) : medicinal properties in alcoholic extraction

Jatropha gossypifolia (Mèdsiyen-wouj, Red Healer, Médicinier rouge) — family Euphorbiaceae.

Scientific synonyms : Adenotropium globulifolium-(L)- Pohl, A. elegans-(Pohl), Jatropha glandulifera-Roxb, J elegans-(P)-Klot.

Recognised external sources linked to this monograph: TRAMIL.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 9 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 74 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ogunma BG (2021)

     Excerpt gossypifolia was subject to diuretics & hyperglycemic properties using established protocol of diuretic & diabetes test on the rat bladders emptied via mild compression in the pelvic region & gently pulling of their tails. gossypifolia leave extract on streptozotocin-induced diabetic rats.

   • According to Singh H (2013)

     Excerpt Decoction prepared from roots of Jatropha gossypifolia Linn is used in the treatment of diabetes & its associated complications. Petroleum ether (60-80°C), chloroform, methanol & aqueous extracts (250 & 500 mg/kg body weight) were orally administered to alloxan-induced diabetic mice for 7 days.

   • According to Rahuja N (2013)

     Excerpt The present study carried out to investigate the antidiabetic & hypolipidemic efficacy of active fractions (chloroform fraction of 95% ethanolic extract & butanol fraction of aqueous extract) of J Gossypifolia L.(stem) by measuring the status of blood glucose, serum insulin, carbohydrate metabolizing enzymes, lipid levels, renal & hepatic parameters on diabetic rats. gossypifolia L.(stem), significantly reduced blood glucose levels of diabetic rats while in multiple dose studies, chloroform fraction of 95% ethanolic extract restored the elevated biochemical parameters significantly to the near normal level in type 2 diabetic rats when compared with standard drug Metformin (100 mg/kg) but butanol fraction of aqueous extract did not show any marked effect.

   • According to Granados S (2015)

     Excerpt (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. Jatropha gossypifolia L.

   • According to Sabandar C.W (2013)

     Excerpt The genus Jatropha (Euphorbiaceae) comprises of about 170 species of woody trees, shrubs, subshrubs or herbs in the seasonally dry tropics of the Old & the New World.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Akinloye OA (2015)

     Excerpt gossypifolia may not have A protective role against chromosomal & liver damage in KBrO3-induced toxicity, but complicating effects. gossypifolia have been reported to have several medicinal values, including potential Anticancer & antiinflammatory properties.

   • According to Jain S (2015)

     Excerpt The results of this study strongly indicate that J gossypifolia leaves have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats. Jatropha gossypifolia has been traditionally used in the Ayurvedic system of medicine as a chief ingredient of many polyherbal formulations as antioxidant.

   • According to dos Reis JM (2013)

     Excerpt The leaves & fruits of J gossypifolia were evaluated for their chemical composition.

   • According to Hosamani KM (2008)

     Excerpt Jatropha gossypifolia & Hevea brasiliensis seed oils were found to contain 18.5% and 18.0% of 12-hydroxyoctadec-cis-9-enoic acid (ricinoleic acid), respectively.

   • According to Rahuja N (2013)

     Excerpt The present study carried out to investigate the antidiabetic & hypolipidemic efficacy of active fractions (chloroform fraction of 95% ethanolic extract & butanol fraction of aqueous extract) of J Gossypifolia L.(stem) by measuring the status of blood glucose, serum insulin, carbohydrate metabolizing enzymes, lipid levels, renal & hepatic parameters on diabetic rats. gossypifolia L.(stem), significantly reduced blood glucose levels of diabetic rats while in multiple dose studies, chloroform fraction of 95% ethanolic extract restored the elevated biochemical parameters significantly to the near normal level in type 2 diabetic rats when compared with standard drug Metformin (100 mg/kg) but butanol fraction of aqueous extract did not show any marked effect.

3. 3

   High blood pressure, oedema, fluid retention

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2014)

     Excerpt Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, & anticancer agents, among others, supporting some of its popular uses. Jatropha gossypifolia L.

   • According to Panda BB (2009)

     Excerpt We have determined the anti-inflammatory and analgesic activity of methanolic and petroleum ether extracts of dried aerial parts of Jatropha gossypifolia by oral administration at doses of 100 and 200 mg/kg/day of body weight to healthy animals. The present study was done to investigate the anti-inflammatory & analgesic effect of methanolic & petroleum ether extracts of Jatropha gossypifolia Linn.

   • According to Xavier-Santos JB (2018)

     Excerpt gossypiifolia showed significant acute anti-inflammatory activity in ear edema model, & this activity was significantly increased when equivalent amounts of extract were applied incorporated in the developed poloxamer gels. gossypiifolia extract was developed, physicochemically characterized & evaluated in the same model of inflammation to assess whether the extract incorporation in gel would affect its anti-inflammatory potential.

   • According to Yerramsetty N (2013)

     Excerpt The present study aimed to evaluate the anti-inflammatory activity of aqueous & alcoholic extract of JG leaves by in vitro HRBC membrane stabilization method Results: The in vitro method showed significant anti-inflammatory property of different extracts tested.

   • According to Rani B (2011)

     Excerpt Methanolic extract of Jatropha gossypifolia leaves showed systemic & significant anti-inflammatory activity in acute carrageenan-induced rat paw edema & chronic cotton pellet induced granuloma formation after oral treatment for 7 days in Wistar rats. Anti-inflammatory activity might be due to effects on several mediators & arachidonic granular tissue formation & leukocyte migration from vessels.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.