Kalantchoe pinnata (Zèb-mal-têt) : medicinal properties in alcoholic extraction

Kalantchoe pinnata (Zèb-mal-têt, tonbé-lévé, Farin Cho) — family Crassulacées.

Scientific synonyms : Cotylédon pinnata-Lam, Bryophyllum pinnatum-(Lam)-Oken, B. Calycinum-Salisb.

Recognised external sources linked to this monograph: TRAMIL and French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 22 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 109 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Shaft.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Matthew S (n.d.)

     Excerpt The main objective of present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, & also it is aimed to investigate Anti-diabetic activity of ethanolic & aqueous extracts of dried stem of plant Kalanchoe pinnata against CNS-Depressant activity in rats.

   • According to Goyal P (2013)

     Excerpt pinnata against alloxan-induced diabetes in rats. pinnata decreased the blood glucose level of rats affected by diabetes.

   • According to Matthew S (n.d.)

     Excerpt The main objective of present work is found out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate Anti-Diabetic activity of ethanolic & aqueous extracts of dried stem of plant Kalanchoe pinnata (LAM.) PERS against alloxan induced diabetes in rats. The alcoholic extract of dried stem of K pinnata shows the significant inhibition activity of α- amylase enzyme as compared to aqueous extract.

   • According to Bandhari R (2021)

     Excerpt This investigation was designed to explore the result shown by methanolic extract of Garuga pinnata bark & Bryophyllum pinnatum leaves, on cognitive power & retention of the memory in experimental mice along with quantification of phenolic compounds & DPPH radicals neutralizing capacity.

   • According to Ramon P (2023)

     Excerpt pinnata treatment (400 µg/mL) alone significantly increased catalase (CAT) activity for non-diabetic & diabetic human skeletal muscle myoblasts & a H2O2-stress-induced human skeletal muscle myoblast cell line, while significantly lowering malondialdehyde (MDA) levels. In this study, the compound composition of Kalanchoe Pinnata & the effects of combined preparations of KP & metformin on antioxidant activity in human skeletal muscle myoblasts (HSMMs) & human diabetic skeletal muscle myoblasts (DHSMMs) were investigated.

2. 2

   Hepatitis, cirrhosis, fatty liver disease

   Plant part used: Sheet. Mentioned synergistic association: Cyperus rotundus.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Yadav NP (2003)

     Excerpt The juice of the leaves & the ethanolic extract of the marc left after expressing the juice were studied in rats against CCl4-induced hepatotoxicity. The test material was found effective as hepatoprotective as evidenced by in vitro, in vivo & histopathological studies.

   • According to Guruswamy K (2010)

     Excerpt The ethanolic extracts of the polyherbal medicinal plants (Asteracantha longifolia, Cyperus rotundus & Bryophyllum pinnatum) were evaluated for hepatoprotective activity in carbon tetrachloride induced liver damage in rats. exhibited a significant protective effect by lowering serum and liver activities of aspartate transaminase (AST), alanine transaminase (ALT), acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum Bilirubin, serum cholesterol & serum total protein when compared with standard silymarin.

   • According to Saravanan V (2021)

     Excerpt Histopathology of the Liver, Heart & Kidney did not show any remarkable lesions that could be related to the administration of the leaf extract. Kalanchoe pinnata is a perennial plant that is widely used in the folklore treatment of kidney & gall stones & urinary insufficiency.

   • According to FAUNDES-Gandolfo N (2024)

     Excerpt pinnata), a succulent plant native to tropical regions, are used as a medicinal alternative against cancer in several countries worldwide; however, its therapeutic potential to fight cancer has been little addressed.

3. 3

   Cancer: adjuvant treatment for breast and colorectal adenocarcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to HERNANDEZ-CABLLERO MA (2022)

     Excerpt This study aimed to identify the bioactive ingredients in Kalanchoe pinnata, a succulent herb with ethnomedical applications for several diseases, including cancer, & reveal its anticancer mechanisms through a molecular approach. pinnata as an adjuvant in cancer treatment.

   • According to FAUNDES-Gandolfo N (2024)

     Excerpt pinnata), a succulent plant native to tropical regions, are used as a medicinal alternative against cancer in several countries worldwide; however, its therapeutic potential to fight cancer has been little addressed. Human cancer (MCF-7, PC-3, HT-29) & normal colon (CoN) cell lines were treated with different concentrations of KP leaf ethanolic extract, & the changes in cell proliferation (sulforhodamine B assay), caspases activity (FITC-VAD-FMK reporter), mitochondrial membrane potential (MMP, rhodamine 123 assay), chromatin condensation/fragmentation (Hoechst 33342 stain), & ROS generation (DCFH2 probe assay) were assessed.

   • According to Ramon P (2021)

     Excerpt Results also indicate that combinatorial preparations of KP may modulate immune responses by significantly upregulating proinflammatory markers, interleukin (IL) 2, & tumor necrosis factor-alpha, & upregulating the anti-inflammatory marker, IL-10, in HSMM & DHSMM cells. In this study, combined preparations of Kalanchoe pinnata & metformin were investigated to determine the effects on inflammatory activity in human skeletal muscle myoblasts (HSMMs) & human diabetic skeletal muscle myoblasts (DHSMMs).

   • According to Mahata S (2012)

     Excerpt Mahata S et al, Anticancer property of Bryophyllum pinnata (Lam.) Oken leaf on human cervical cancer cells.

   • According to Stefanowicz-Hajduk J (2020)

     Excerpt blossfeldiana ethanol extract did not show the presence of these compounds, Conclusion: K blossfeldiana ethanol extract is a potential candidate for cancer & bacterial infection treatment. Cytotoxicity tests were performed on human cancer cell lines – HeLa, SKOV-3, MCF-7, & A375 by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay & Real-Time Cell Analysis system.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.