Kigelia africana (Sausage maker) : medicinal properties in alcoholic extraction

Kigelia africana (Sausage maker, Sosisonié, Saucissonier) — family Bignoniacées.

Scientific synonyms : Kigelia aethiopica Dcne, K pinnata (Jacq.) D..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 18 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 78 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ogunfowora A (2021)

     Excerpt This study investigates the effect of the ethanolic extract of Kigelia africana (EEKA) on reproductive functions in streptozotocin-induced diabetic male rats. Kigelia africana is reported to offer therapeutic influence in diabetes.

   • Excerpt According to Fagbohun O (2020) — excerpt:

   • Excerpt According to molecular docking study, the use of the base structure of 2,4-ditert-butylphenol identified from K.A fruit may serve as the novel approach to the treatment of diabetes mellitus. Molecular docking study was used to predict the activities of these metabolites in relation to diabetes mellitus.

   • According to Kumar S (2012)

     Excerpt Kumar S et al, Antidiabetic & hypolipidemic activities of Kigelia pinnata flowers extract in streptozotocin induced diabetic rats Asian Pac Jl of Trop Biomed (2012)543-546,.

   • According to Emeka A (2014)

     Excerpt A comparative study on the effect of ethanol bark & methanol leaf extract of Kigelia africana on some biochemical parameters in alloxan induced diabetic rats, was carried out. Twenty-five (25) male albino rats were divided into five groups: normal rats (group 1), diabetic untreated rats (group 2), diabetic rats treated with Glibenclamide (group 3), diabetic rats treated with ethanol bark extract (group 4) & diabetic rats treated with methanol leaf extract (group 5), with groups 1 & 2 serving as positive & negative control respectively.

   • According to Nyarko AK (2018)

     Excerpt The subchronic toxicity of the aqueous antidiabetic herbal extract ADD-199, prepared from Maytemus senegalensis, Annona senegalensis, Kigelia africana & Lannea welwitschia & administered at a daily dose of 100 or 500mg/kg body weight over 30 days, was investigated in male Wistar albino rats.

2. 2

   Bacterial infection: Staphylococcus aureus, Proteus vulgaris, E. coli, P. aeruginosa, K. pneumoniae, Citrobacter amalonaticus

   Plant part used: Stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Author (2016)

     Excerpt Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae & Citrobacter amalonaticus by agar-disc diffusion method. Ethanolic & aqueous extracts of bark & leaves of Kigelia africana showed remarkable activity against various bacterial strains as compared to n-hexane.

   • According to OLUBUKOLA JO (2011)

     Excerpt Methodology: Crude extracts of fresh leaves of Ocimum gratissimum, Psidium guajava, Vernonia amygdalina, Kigelia africana, Azadirachta indica, Pistia stratiotes, Euphorbia hirta, bulb of Allium sativum & Zingiber officinale & Curcuma longa, were evaluated using the agar diffusion assay method & minimal inhibitory concentration (MIC) to determine the antibacterial activities against Vibrio Cholerae, Escherichia Coli & salmonella Sp. Was not inhibited by ethanolic extracts of Euphorbia hirta & Curcuma longa, both water and ethanolic extracts of others inhibited the growth of Vibrio Cholerae, Escherichia coli & salmonella Sp to varying degree.

   • According to Agyare C (2013)

     Excerpt The study was to investigate antimicrobial & antioxidant properties of methanol leaf & stem bark extracts of Kigelia africana & methanol leaf & root extracts of Strophanthus hispidus & also to determine wound healing properties of the extracts. The antimicrobial activities of the methanol extracts were determined against two Gram-positive & two Gram-negative bacteria & a fungus using agar diffusion & micro-dilution methods.

   • According to Akunyili DN (1991)

     Excerpt Akunyili DN et al, antimicrobial activities of the stem bark of Kigelia pinnata Jl Ethnopharmacol 1991; 35(2), 173-7.

   • According to Kaur A (2013)

     Excerpt In this study Kigelia Africana fruit was selected for assessing the level of various Phytochemicals, enzymatic and non- enzymatic antioxidants a& antimicrobial activity. Results of the study showed that aqueous extract of K Africana have significant amount of phytochemicals & antioxidant enzymes so useful to prevent chronic diseases related to oxidative stress in human body.

3. 3

   Cancer; adjuvant treatment of renal carcinoma, leukaemia and melanoma

   Plant part used: Stem bark.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Olufemi AE (2017)

     Excerpt Conclusion: This study revealed the potential of ethanol extracts of K africana stem bark, fruit a leaf to reverse leukaemic effects in benzène-induced leukemia bearing Wistar rats and this suggest that the extracts might be promising natural, non-Toxic and anticancer agents. Methodology: Rats were administered 0.2 mL of benzène solution intravenously through the tail 48-hourly for 4 weeks, tested periodically & observed till leukaemia developed prior to treatment with respective extract of the Kigelia africana stem bark, fruit and leaf in appropriate rat groups after leukaemia was confirmed with haematological protocols.

   • According to Momekova D (2012)

     Excerpt The study was aimed to assess the antineoplastic activity of a total methanolic extract (TME) from the stem bark of Kigelia pinnata - an African medicinal plant with well-documented ethnopharmacological use. Conclusion: On the basis of the in vitro studies and the observed in vivo antineoplastic potential of the plant it could be concluded that there is enormous scope for future investigations on KA as à source of potential anticancer agents.

   • According to Houghton PJ (1994)

     Excerpt Serial dilutions of standardised water, ethanol, & dichloromethane extracts of the stem-bark and fruits of Kigelia pinnata were tested for their growth inhibitory effects against four melanoma cell lines & a renal cell carcinoma line (Caki-2) using two different (MTT & SRB) assays. Chemosensitivity of the melanoma cell lines to the stembark was greater than that seen for the renal adenocarcinoma line.

   • According to Jackson SJ (2000)

     Excerpt Crude dichloromethane extracts of Kigelia pinnata stem bark & fruit showed cytotoxic activity in vitro against cultured melanoma and other cancer cell lines using the Sulphorhodamine B assay, which was used for bioassay-guided fractionation. Norviburtinal was found to be the most active compound but had little selectivity for melanoma cell lines whilst isopinnatal also showed some cytotoxic: activity.

   • According to Fatokun OT (2021)

     Excerpt Kigelia africana (Bignoniaceae) is enriched with bioactive constituents and has thus found various uses in African folklore. Results of antiproliferative assay showed that methotrexate was significantly (p ˂ 0.05) more effective than the stem bark (from 2-64 mg/mL) with inhibitions ranging from 72.0 ± 1.4% - 90.0 ± 2.4% & root extracts (from 4 – 64 mg/mL) that had inhibitions ranging from 50.3 ± 1.5% - 97.7 ± 0.4% but comparable with leaf extract (from 16 mg/mL - 64 mg/mL) with inhibitions ranging from 68.4 ± 0.8% - 99.0 ± 0.1%.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.