Kigelia africana (Sosisonié) : vertus médicinales en extraction alcoolique

Kigelia africana (Sosisonié, Saucissonier, Sausage maker) — famille Bignoniacées.

Synonymes scientifiques : Kigelia aethiopica Dcne, K pinnata (Jacq.) D..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 18 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 78 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Diabète mellitus de type II

   Partie usitée : Écorce. Profil pharmacologique documenté : Glibenclamide-like.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • Selon Ogunfowora A (2021)

     Excerpt This study investigates the effect of the ethanolic extract of Kigelia africana (EEKA) on reproductive functions in streptozotocin-induced diabetic male rats. Kigelia africana is reported to offer therapeutic influence in diabetes.

   • Excerpt Selon Fagbohun O (2020) — extrait :

   • Excerpt According to molecular docking study, the use of the base structure of 2,4-ditert-butylphenol identified from K.A fruit may serve as the novel approach to the treatment of diabetes mellitus. Molecular docking study was used to predict the activities of these metabolites in relation to diabetes mellitus.

   • Selon Kumar S (2012)

     Excerpt Kumar S et al, Antidiabetic & hypolipidemic activities of Kigelia pinnata flowers extract in streptozotocin induced diabetic rats Asian Pac Jl of Trop Biomed (2012)543-546,.

   • Selon Emeka A (2014)

     Excerpt A comparative study on the effect of ethanol bark & methanol leaf extract of Kigelia africana on some biochemical parameters in alloxan induced diabetic rats, was carried out. Twenty-five (25) male albino rats were divided into five groups: normal rats (group 1), diabetic untreated rats (group 2), diabetic rats treated with Glibenclamide (group 3), diabetic rats treated with ethanol bark extract (group 4) & diabetic rats treated with methanol leaf extract (group 5), with groups 1 & 2 serving as positive & negative control respectively.

   • Selon Nyarko AK (2018)

     Excerpt The subchronic toxicity of the aqueous antidiabetic herbal extract ADD-199, prepared from Maytemus senegalensis, Annona senegalensis, Kigelia africana & Lannea welwitschia & administered at a daily dose of 100 or 500mg/kg body weight over 30 days, was investigated in male Wistar albino rats.

2. 2

   Infection bacterienne: Staphylococcus aureus, Proteus vulgaris, E coli, P aeruginosa, K pneumoniae, Citrobacter amalonaticus

   Partie usitée : Écorce de tige. Profil pharmacologique documenté : Oxytetracycline-like, Amoxicilline-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Auteur (2016)

     Extrait Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae & Citrobacter amalonaticus by agar-disc diffusion method. Ethanolic & aqueous extracts of bark & leaves of Kigelia africana showed remarkable activity against various bacterial strains as compared to n-hexane.

   • Selon OLUBUKOLA JO (2011)

     Extrait Methodology: Crude extracts of fresh leaves of Ocimum gratissimum, Psidium guajava, Vernonia amygdalina, Kigelia africana, Azadirachta indica, Pistia stratiotes, Euphorbia hirta, bulb of Allium sativum & Zingiber officinale & Curcuma longa, were evaluated using the agar diffusion assay method & minimal inhibitory concentration (MIC) to determine the antibacterial activities against Vibrio Cholerae, Escherichia Coli & salmonella Sp. Was not inhibited by ethanolic extracts of Euphorbia hirta & Curcuma longa, both water and ethanolic extracts of others inhibited the growth of Vibrio Cholerae, Escherichia coli & salmonella Sp to varying degree.

   • Selon Agyare C (2013)

     Extrait The study was to investigate antimicrobial & antioxidant properties of methanol leaf & stem bark extracts of Kigelia africana & methanol leaf & root extracts of Strophanthus hispidus & also to determine wound healing properties of the extracts. The antimicrobial activities of the methanol extracts were determined against two Gram-positive & two Gram-negative bacteria & a fungus using agar diffusion & micro-dilution methods.

   • Selon Akunyili DN (1991)

     Extrait Akunyili DN et al, antimicrobial activities of the stem bark of Kigelia pinnata Jl Ethnopharmacol 1991; 35(2), 173-7.

   • Selon Kaur A (2013)

     Extrait In this study Kigelia Africana fruit was selected for assessing the level of various Phytochemicals, enzymatic and non- enzymatic antioxidants a& antimicrobial activity. Results of the study showed that aqueous extract of K Africana have significant amount of phytochemicals & antioxidant enzymes so useful to prevent chronic diseases related to oxidative stress in human body.

3. 3

   Cancer ; traitement adjuvant du carcinome renal, de la leucémie et mélanome

   Partie usitée : Écorce de tige.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Olufemi AE (2017)

     Extrait Conclusion: This study revealed the potential of ethanol extracts of K africana stem bark, fruit a leaf to reverse leukaemic effects in benzène-induced leukemia bearing Wistar rats and this suggest that the extracts might be promising natural, non-Toxic and anticancer agents. Methodology: Rats were administered 0.2 mL of benzène solution intravenously through the tail 48-hourly for 4 weeks, tested periodically & observed till leukaemia developed prior to treatment with respective extract of the Kigelia africana stem bark, fruit and leaf in appropriate rat groups after leukaemia was confirmed with haematological protocols.

   • Selon Momekova D (2012)

     Extrait The study was aimed to assess the antineoplastic activity of a total methanolic extract (TME) from the stem bark of Kigelia pinnata - an African medicinal plant with well-documented ethnopharmacological use. Conclusion: On the basis of the in vitro studies and the observed in vivo antineoplastic potential of the plant it could be concluded that there is enormous scope for future investigations on KA as à source of potential anticancer agents.

   • Selon Houghton PJ (1994)

     Extrait Serial dilutions of standardised water, ethanol, & dichloromethane extracts of the stem-bark and fruits of Kigelia pinnata were tested for their growth inhibitory effects against four melanoma cell lines & a renal cell carcinoma line (Caki-2) using two different (MTT & SRB) assays. Chemosensitivity of the melanoma cell lines to the stembark was greater than that seen for the renal adenocarcinoma line.

   • Selon Jackson SJ (2000)

     Extrait Crude dichloromethane extracts of Kigelia pinnata stem bark & fruit showed cytotoxic activity in vitro against cultured melanoma and other cancer cell lines using the Sulphorhodamine B assay, which was used for bioassay-guided fractionation. Norviburtinal was found to be the most active compound but had little selectivity for melanoma cell lines whilst isopinnatal also showed some cytotoxic: activity.

   • Selon Fatokun OT (2021)

     Extrait Kigelia africana (Bignoniaceae) is enriched with bioactive constituents and has thus found various uses in African folklore. Results of antiproliferative assay showed that methotrexate was significantly (p ˂ 0.05) more effective than the stem bark (from 2-64 mg/mL) with inhibitions ranging from 72.0 ± 1.4% - 90.0 ± 2.4% & root extracts (from 4 – 64 mg/mL) that had inhibitions ranging from 50.3 ± 1.5% - 97.7 ± 0.4% but comparable with leaf extract (from 16 mg/mL - 64 mg/mL) with inhibitions ranging from 68.4 ± 0.8% - 99.0 ± 0.1%.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.