Lagenaria siceraria (Goud Sèpan) : medicinal properties in alcoholic extraction

Lagenaria siceraria (Goud Sèpan, Goud boutèy, Snake-shaped flask, Bottle-shaped flask, Gourde serpent, Gourde bouteille) — family Cucurbitacées.

Scientific synonyms : Cucumis bicirrha G.Forst. ex Guill. Cucurbita idolatrica Willd., C lagenaria L. Cucurbita leucantha Duchesne, C siceraria Molina, Lagenaria idolatrica (Willd.) Ser. ex Cogn., L lagenaria (L.) Cockerell, L leucantha (Duchesne) Rusby, L vulgaris Ser..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 107 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Hepatotoxicity caused by anti-tuberculosis drugs (Isoniazid/Rifampicin/Pyrazinamide)

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Funde SK (2013)

     Excerpt Hence in the present study we tested hepatoprotective & antioxidant activity of fruit extract of LS in anti-tubercular drug induced hepatotoxicity., Methods: We administered antitubercular drugs alone & in combination with fruit extract of LS (EELS 100mg/kg & EELS 200mg/kg) in healthy albino rats by oral route for 15 days. Conclusion: Ethanolic extract of LS fruit possesses significant hepatoprotective & antioxidant activity in antitubercular drugs induced hepatotoxicity.

   • According to Prajapati RP (2010)

     Excerpt Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, & antibacterial effects so that its potential uses in pharmaceutics can be better evaluated. Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical & subtropical regions.

   • According to Panchal CV (2013)

     Excerpt Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice & to cure certain liver disorders. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively.

   • According to Owais F (2019)

     Excerpt To determine the hepatoprotective effect of Lagenaria Siceraria in carbamazepine induced hepatotoxicity in rabbits, STUDY DESIGN: A Randomized controlled trial (experimental animal study). CONCLUSION: Hepatoprotective potential of L.S suggested its use to prevent elevation of hepatic enzymes due to long term administration of carbamazepine.

   • According to Chakraborty I (2020)

     Excerpt The past three decades witnessed increasing investigation of the polysaccharides isolated from different parts of the plant, & the polysaccharides were reported to show immune-enhancing, anti-tumor, antihyperlipidemic, cardioprotective, analgesic, anti-inflammatory anti-diabetic, antioxidant & hepatoprotective effects. Lagenaria siceraria (family cucurbitaceae, herbaceous climbing plant) commonly known as bottle gourd, is a medicinal plant, various parts of which have been recognized for their pharmacological potential.

2. 2

   Hepatotoxicity: abnormal serum levels of ALT, AST, ALP, MDA, SOD and bilirubin

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Funde SK (2013)

     Excerpt Results: Groups that received EELS [100 mg/kg & 200 mg/kg], in combination with anti-tubercular drugs, showed significant reduction [p value <0.001] in biochemical parameters for hepatotoxicity [SGOT, SGPT, ALP, Total bilirubin, Total protein] in comparison with group that received anti tubercular drugs alone. Lagenaria siceraria [Bottle Gourd] is reported to have antioxidant & hepatoprotective activity.

   • According to Panchal CV (2013)

     Excerpt Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice & to cure certain liver disorders. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively.

   • According to Owais F (2019)

     Excerpt To determine the hepatoprotective effect of Lagenaria Siceraria in carbamazepine induced hepatotoxicity in rabbits, STUDY DESIGN: A Randomized controlled trial (experimental animal study). RESULTS: LS fruit extract significantly reduced liver enzymes, SGPT (66%), ALP (47%), γ-GT (14%) and total proteins (5.5%), whereas the levels of SGPT (7.2%), ALP (80%), γ-GT (7.6%) & total proteins (22.1%) in CBZ treated group were elevated.

   • According to Prajapati RP (2010)

     Excerpt Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical & subtropical regions. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, & antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

   • According to Almohmadi NJ (2016)

     Excerpt Aim: The experiment aimed to determine the efficacy of Lagenaria siceraria seed oil (LSS) as a hepatoprotective agent against acute hepatotoxicity triggered by carbon tetrachloride (CCl4). Results: In CCl4-treated rats, there was a significant increase in serum liver marker enzyme activity (ALP, AST, & ALT) along with a significant elevation (p < 0.05) in total bilirubin, indirect bilirubin, & direct bilirubin compared to the control rats.

3. 3

   Cancer: adjuvant treatment of invasive breast cancer and melanoma

   Plant part used: Fruit.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Huang CC (2023)

     Excerpt Molecularly, cucurbitacin B caused reduction of the metastasis-promoting gene Snail in melanoma & one of the cancer stem cell markers, ALDH1A1 (aldehyde dehydrogenase 1 A1), in breast cancer. We also found that cucurbitacin B significantly reduced the invasiveness of at least two highly metastatic breast cancer & melanoma cells.

   • According to Aggrawal RC (2016)

     Excerpt The present study was carried out to evaluate the anti-cancer activity of methanolic extract of Lagenaria siceraria on skin Papilloma model in mice. A significant reduction in tumor incidence, tumor burden & cumulative number of papillomas was observed, along with a significant increase in average latent period in mice treated topically with LS extract as compared to the control group treated with DMBA & croton oil.

   • According to Author (2013)

     Excerpt Methanolic extract of Lagenaria siceraria Standley Fruit was tested for their antimutagenic potential. Many of the Cucurbitaceae plants possess antitumor activity traditionally.

   • According to Shaneh M (2021)

     Excerpt Lagenaria siceraria Standl is critical for cytotoxicity studies due to its polyphenolic, cucurbitacins, pectin, flavonoids, & saponin compounds. Then, the effects of solutions containing samples with different concentrations (5000, 500, 1000, 100, 100, 250, 10, 1, 0.1μg.ml-1) were investigated by MTT assay on lung cancer cell line (A549).

   • According to Kumar N (2013)

     Excerpt In the present study, we have evaluated Lagenaria siceraria (bottle gourd), a common vegetable of Indian household for its chemomodulatory potential. Kumar N et al, Chemopreventive effect of Lagenaria siceraria in two stages DMBA plus croton oil induced skin papillomagenesis.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.