Lagenaria siceraria (Goud Sèpan) : vertus médicinales en extraction alcoolique

Lagenaria siceraria (Goud Sèpan, Goud boutèy, Gourde serpent, Gourde bouteille, Snake-shaped flask, Bottle-shaped flask) — famille Cucurbitacées.

Synonymes scientifiques : Cucumis bicirrha G.Forst. ex Guill. Cucurbita idolatrica Willd., C lagenaria L. Cucurbita leucantha Duchesne, C siceraria Molina, Lagenaria idolatrica (Willd.) Ser. ex Cogn., L lagenaria (L.) Cockerell, L leucantha (Duchesne) Rusby, L vulgaris Ser..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 8 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 107 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Hépatotoxicité induite par les drogues antituberculeuses (Isoniazide/Rifampicine/Pyrazinamide)

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Funde SK (2013)

     Extrait Hence in the present study we tested hepatoprotective & antioxidant activity of fruit extract of LS in anti-tubercular drug induced hepatotoxicity., Methods: We administered antitubercular drugs alone & in combination with fruit extract of LS (EELS 100mg/kg & EELS 200mg/kg) in healthy albino rats by oral route for 15 days. Anti TB drug induced hepatotoxicity has higher incidence in Indian population [11.5%] than western population [4.5%].

   • Selon Prajapati RP (2010)

     Extrait Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, & antibacterial effects so that its potential uses in pharmaceutics can be better evaluated. Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical & subtropical regions.

   • Selon Panchal CV (2013)

     Extrait Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice & to cure certain liver disorders. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively.

   • Selon Owais F (2019)

     Extrait To determine the hepatoprotective effect of Lagenaria Siceraria in carbamazepine induced hepatotoxicity in rabbits, STUDY DESIGN: A Randomized controlled trial (experimental animal study). CONCLUSION: Hepatoprotective potential of L.S suggested its use to prevent elevation of hepatic enzymes due to long term administration of carbamazepine.

   • Selon Chakraborty I (2020)

     Extrait The past three decades witnessed increasing investigation of the polysaccharides isolated from different parts of the plant, & the polysaccharides were reported to show immune-enhancing, anti-tumor, antihyperlipidemic, cardioprotective, analgesic, anti-inflammatory anti-diabetic, antioxidant & hepatoprotective effects. Lagenaria siceraria (family cucurbitaceae, herbaceous climbing plant) commonly known as bottle gourd, is a medicinal plant, various parts of which have been recognized for their pharmacological potential.

2. 2

   Hépatotoxicité : anormalité des paramètres sériques :ALT, AST, ALP, MDA SOD, Bilirubine

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Funde SK (2013)

     Extrait Results: Groups that received EELS [100 mg/kg & 200 mg/kg], in combination with anti-tubercular drugs, showed significant reduction [p value <0.001] in biochemical parameters for hepatotoxicity [SGOT, SGPT, ALP, Total bilirubin, Total protein] in comparison with group that received anti tubercular drugs alone. Lagenaria siceraria [Bottle Gourd] is reported to have antioxidant & hepatoprotective activity.

   • Selon Panchal CV (2013)

     Extrait Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice & to cure certain liver disorders. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively.

   • Selon Owais F (2019)

     Extrait To determine the hepatoprotective effect of Lagenaria Siceraria in carbamazepine induced hepatotoxicity in rabbits, STUDY DESIGN: A Randomized controlled trial (experimental animal study). CONCLUSION: Hepatoprotective potential of L.S suggested its use to prevent elevation of hepatic enzymes due to long term administration of carbamazepine.

   • Selon Prajapati RP (2010)

     Extrait Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical & subtropical regions. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, & antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

   • Selon Almohmadi NJ (2016)

     Extrait Aim: The experiment aimed to determine the efficacy of Lagenaria siceraria seed oil (LSS) as a hepatoprotective agent against acute hepatotoxicity triggered by carbon tetrachloride (CCl4). Results: In CCl4-treated rats, there was a significant increase in serum liver marker enzyme activity (ALP, AST, & ALT) along with a significant elevation (p < 0.05) in total bilirubin, indirect bilirubin, & direct bilirubin compared to the control rats.

3. 3

   Cancer : traitement adjuvant du carcinome mammaire et du mélanome invasifs

   Partie usitée : Fruit.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Huang CC (2023)

     Extrait Molecularly, cucurbitacin B caused reduction of the metastasis-promoting gene Snail in melanoma & one of the cancer stem cell markers, ALDH1A1 (aldehyde dehydrogenase 1 A1), in breast cancer. We also found that cucurbitacin B significantly reduced the invasiveness of at least two highly metastatic breast cancer & melanoma cells.

   • Selon Aggrawal RC (2016)

     Extrait The present study was carried out to evaluate the anti-cancer activity of methanolic extract of Lagenaria siceraria on skin Papilloma model in mice. A significant reduction in tumor incidence, tumor burden & cumulative number of papillomas was observed, along with a significant increase in average latent period in mice treated topically with LS extract as compared to the control group treated with DMBA & croton oil.

   • Selon Auteur (2013)

     Extrait Methanolic extract of Lagenaria siceraria Standley Fruit was tested for their antimutagenic potential. Many of the Cucurbitaceae plants possess antitumor activity traditionally.

   • Selon Shaneh M (2021)

     Extrait Lagenaria siceraria Standl is critical for cytotoxicity studies due to its polyphenolic, cucurbitacins, pectin, flavonoids, & saponin compounds. Then, the effects of solutions containing samples with different concentrations (5000, 500, 1000, 100, 100, 250, 10, 1, 0.1μg.ml-1) were investigated by MTT assay on lung cancer cell line (A549).

   • Selon Kumar N (2013)

     Extrait In the present study, we have evaluated Lagenaria siceraria (bottle gourd), a common vegetable of Indian household for its chemomodulatory potential. Kumar N et al, Chemopreventive effect of Lagenaria siceraria in two stages DMBA plus croton oil induced skin papillomagenesis.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.