Laportea aestuans (Zôti) : medicinal properties in alcoholic extraction

Laportea aestuans (Zôti, Zouti Brilant, Stinging nettle, Ortie, Ortie brulante) — family Urticacées.

Scientific synonyms : Urtica aestuans-L, Fleurya aestuans-(L)-Gaudich.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 11 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 42 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for leukaemia

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Aladesanmi A.J (2020)

     Excerpt The study investigated eight Nigerian medicinal plants: Artocarpus communis fruit (Ac-F), Cassia sieberiana root bark (Cs-R), Eugenia uniflora leaf (Eu-L), Hibiscus rosa-sinensis flower (Hr-F), Laportea aestuans aerial part (La-A), Massularia acuminata stem bark (Ma-S), Trichilla heudelotii leaf (Th-L), & Xylopia aethiopica fruit (Xa-F), for anticancer activity. The results showed a concentration dependent decrease in cancer cell viability & cytotoxicity of four of the extracts, namely MA stem bark (Ma-S), XA fruit (Xa-F (La-A),), L aestuans aerial part (XP) & E uniflora leaf (Eu-L).

   • According to TIJANI AS (2022)

     Excerpt Laportea aestuans (Urticaceae) plant is widely distributed in tropical rain forests & used as remedial agent for various diseases in Nigeria by herbal practitioners. This study investigated the cytoprotective effect of pretreatment with methanol extract of L aestuans (MELA) for 7 days on ethanol-induced gastric ulcer in male Wistar rats using cimetidine as a standard drug.

   • According to ODO EC (2024)

     Excerpt This study evaluated the ameliorative effect of Hydrocotyle verticillata (H.v) & Laportea aestuans (L.a) leaves extracts on hematological, biochemical & histopathological indices on 7,12-dimethylbenz(α) anthracene (DMBA) induced-leukemia in Wistar rats. HV & LA have shown to possess hepato-renal protective effect & modulated hematological indices in induced-leukemia,.

   • According to ODO EC (2022)

     Excerpt Leukemia has been linked to mRNA expression of Sphingosine-1-phosphate receptor-1(S1PR-1) & considering multiple reports on the roles of phytochemicals in Hydrocotyle verticillata & Laportea aestuans, this study aims to evaluate the effects of administration of ethanol extracts of the 2 plants in regulation of mRNA expression of S1PR-1 in leukemia induced by 7,12-dimethylbenz(α) anthracene (DMBA) in rats. Conclusion: This outcome of the present study has shown that the plant extracts upregulated the mRNA expression of S1PR1 in a leukemic rat hence can be used as an adjunct in leukemia treatment,.

2. 2

   Bacterial infection: Escherichia coli, Salmonella Typhi & Staphylococcus aureus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Siahaya EV (2025)

     Excerpt This study aims to analyze the comparison between Laportea decumana & Laportea aestuans, focusing on the two main aspects, phytochemical screening & antibacterial activity. The antibacterial test using agar diffusion method shows that both extracts inhibited the growth of pure strains of E.

   • According to Simaremare ES (2017)

     Excerpt The aim of the study was to determine the activity of antibacteria of LA against Escherichia coli, Staphylococcus aureus & Salmonella typhi. Daun gatal (Laportea aestuans) is an indigenous plant of Papua hich has been widely used for pain relief as traditional medication in the local community.

   • According to OLEYODE G (2011)

     Excerpt The oils showed appreciable antimicrobial activity -against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Candida albicans, Rhizopus stolon, Aspergillus niger & Penicillium notatum at 200mg/ml when compared to standards; gentamicin for bacteria & tioconazole for fungi. The colourless essential oils obtained by hydro-distillation from the whole plant of Laportea aestuans (Gaud) were analysed by GC & GC/MS.

   • According to Oloyede GK (2016)

     Excerpt Oloyede GK et al, Toxicity, antimicrobial & antioxidant activities of methyl salicylate dominated essential oils of Laportea aestuans (Gaud).

   • According to KAMBU J (2024)

     Excerpt Penelitian ini bertujuan mengevaluasi aktivitas antibakteri ekstrak etanol kedua spesies terhadap Staphylococcus aureus & Escherichia coli menggunakan metode difusi cakram dan bioautografi. Laportea interrupta dan Laportea aestuans, dikenal sebagai daun gatal, merupakan tanaman asli Papua yang digunakan secara tradisional untuk meredakan nyeri & pegal melalui aplikasi topikal.

3. 3

   Osteoarthritis, arthritis, rheumatism, oedema

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Ashidi J (2017)

     Excerpt In traditional medicine, Laportea aestuans (LA) is used in treatment of several ailments including pain & inflammatory conditions. This study evaluates the analgesic & anti-inflammatory potential of the ethanol extract of the leaves of LA using hot-plate induced analgesia and carrageenan-induced acute inflammatory model in Albino Wistar rats (120g-160g).

   • According to Simaremare ES (2018)

     Excerpt Then ELA was evaluated analgesic with tail flick test & anti-inflammatory effect with carrageen-induced paw edema with 0.3 g/kg, 0.6g/kg, & 1.2g/kg dose on white male rat. Laportea aestuans (Linn.) Chew as original plant from Papua has been using for pain relief as traditional medication in the local community widely.

   • According to Nwafor CC (2022)

     Excerpt Acute inflammation was produced in the anti-inflammatory trial groups by injecting 0.1 ml of egg albumin sub-plantarly into the left hind paw. The goal of this study is to see if hydroethanolic extract of Fleurya aestuans can reduce pyrexia & inflammation in Wistar rats.

   • According to Onadeko A (2021)

     Excerpt Non-steroidal anti-inflammatory drugs (NSAIDs) are connected with the generation of free radicals & one of its adverse effects is gastric ulceration. In conclusion, the ethanoic extract of LA can be said to be used as an anti-ulcerogenic agent against aspirin-induced gastric ulcer which is due to the presence of phytochemicals in the plant,.

   • According to Akinwande O (2021)

     Excerpt toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) are being reported with its diverse effect in the host resulting in ulcerations. In conclusion, the ethanoic extract of LE can be said to be used therapeutically against aspirin-induced gastric ulcer which is due to the presence of bioactive compounds in the plant as an anti-ulcerogenic agent against aspirin-induced gastric ulcer which is due to the presence of phytochemicals in the plant.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.