Laurus nobilis (Lôyé-sôs) : medicinal properties in alcoholic extraction

Laurus nobilis (Lôyé-sôs, Sauce laurel, Laurier-à-sauce) — family Lauracées.

Scientific synonyms : Laurus vulgaris-Duhamel.

Recognised external sources linked to this monograph: French Pharmacopoeia.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 73 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bourebaba N (2021)

     Excerpt The aim of this study was to establish the potential effect of Laurus nobilis ethanolic extract on improving insulin sensitivity & protecting liver cells from apoptosis, mitochondrial dysfunction, oxidative stress (OS), & inflammation; all of which considered as major alterations occurring during insulin resistance (IR) as well as diabetes onset, in hyperinsulinemic & hyperglycemic-induced HepG2 cell line. Subsequently, HepG2 cells were pre-treated with an optimal concentration of LN ethanolic extract for 24 h, & then, subjected to 30 mM D-glucose & 500 nM insulin mixture for another 24 h in order to induce hyperinsulinemia & hyperglycaemia (HI/HG) status.

   • According to Rafaat Mohammed R (2021)

     Excerpt This study aimed to investigate the activity of L nobilis leave extracts on histopathological & biochemical changes in β-cells of streptozotocin (STZ)-induced diabetic rats. Thirty healthy adult male albino rats were included in the study & divided equally into 5 groups for 4 weeks as follow; control group (C), diabetic group (D), diabetic L nobilis extract group (DLN), L nobilis extract group (LN) & diabetic acarbose (DA) group.

   • According to Basak SS (2013)

     Excerpt The present study was designed to determine the effects of the essential oil of Laurus nobilis & its three main components on α-glucosidase & reactive oxygen species scavenging activity. An α-glucosidase inhibition assay was applied to evaluate the in-vitro antidiabetic activity of the essential oil.

   • According to Duletić-Laušević S (2019)

     Excerpt Since the oxidative stress results in development of numerous diseases, among them neurodegeneration & diabetes, the antioxidant activity, antineurodegenerative & antidiabetic activities were analyzed, aiming to compare potential of plants cultivated under natural conditions & commercially purchased from the market, as well as to compare the effect of different solvents applied in the extraction process. Ocimum basilicum (sweet basil) & Laurus nobilis (bay leaves or laurel) have been used in traditional medicine for centuries, & also extensively employed as spices for adding aroma & flavor to various food products.

   • According to Fang F (2005)

     Excerpt The goal of this study was to identify compounds from Laurus nobilis, which are responsible for inducing apoptosis using bioassay-directed isolation. Bay leaf has been used as herbal medicine & has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes & anti-inflammatory effects.

2. 2

   Cancer: adjuvant treatment for hepatocellular carcinoma

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Bourebaba N (2021)

     Excerpt The aim of this study was to establish the potential effect of Laurus nobilis ethanolic extract on improving insulin sensitivity & protecting liver cells from apoptosis, mitochondrial dysfunction, oxidative stress (OS), & inflammation; all of which considered as major alterations occurring during insulin resistance (IR) as well as diabetes onset, in hyperinsulinemic & hyperglycemic-induced HepG2 cell line. Taken together, obtained data suggest that LN ethanolic extract offers new insights in the development of potential antioxidant, insulin sensitizing as well as hepatoprotective drugs,.

   • According to Gasparyan G (2015)

     Excerpt Gasparyan G et al, Effect of Laurus nobilis extract on the functioning of liver against CCl4 induced toxicity.

   • According to Gany SZ (2010)

     Excerpt Activity against AMN3 (mouse mammary adenocarcinoma), REF (rat embryo fibroblast) & Hela (cervical human carcinoma cell line taken from Henrietta Lacks established 1951) was established with OD of 0.054, 0.05 & 0.1 respectively at the concentration 500 µg/ml with incubation period 24 h. In this study, the effect of Laurus nobilis hexan extract on three different cell lines was investigate in an attempt to identify its potential activity.

   • According to Al-Kaladeh JZ (2010)

     Excerpt The ethanol crude extracts of O syriacum, L nobilis, & S triloba showed antiproliferative activity to MCF7 with IC (50) values 6.40, 24.49, & 25.25 microg/mL, respectively. In the present study, selected spices used in Jordan were chemically analyzed & investigated for their antiproliferative activity to the adenocarcinoma of breast cell line (MCF7).

   • According to Marza Hamza N (2021)

     Excerpt A number of 36 male albino rats (Wistar) were randomly assigned to six groups (n=6) and treated for 30 days: Group 1 was regarded as the control group, Group 2 received Aluminum Chloride 90 mg/kg body weight orally by gavage, Group3: normal rats received aqueous extracts of LN leaf 150 mg/kg body weight, Group 4: normal rats received aqueous extracts of LN leaf 200 mg/kg body weight, Group 5: normal rats received aqueous extracts of LN leaf 150 mg/kg body weight after a period of 4 h following treatment by Aluminum Chloride 90 mg/kg body weight, Group 6: normal rats received aqueous extracts of Laurus nobilis L. Moreover, the liver enzymes & immune cytokines, such as Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), & Aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha), & interleukin-10 (IL-10) were measured.

3. 3

   Bacterial infection: Bacillus subtilis, Staphylococcus aureus, S. epidermidis, Escherichia coli and Pseudomonas aeruginosa

   Plant part used: Sheet.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Erturk O (2011)

     Excerpt Eleven ethanolic extracts from spices of Melissa officinalis(FR:FE), Mentha piperita((Se), Laurus nobilis(Fe), Rhus coriaria, Dianthus coryophyllum, Piper nigrum(Se), Capsicum annum (Fr), Juniperus oxycedrus, Erica arborea, Colutea arborescens, & Cuminum cyminum(Fr) collected from various regions of Turkey & local markets were assayed for the in vitro antibacterial activity against 3 Gram-positive (Bacillus subtilis, Staphylococcus aureus & S. epidermidis) & 2 Gram-negative bacteria (Escherichia coli & Pseudomonas aeruginosa), using agar dilution methods.

   • According to Ramos C (2012)

     Excerpt The aim of this study was to characterise the antibacterial & antioxidant activities of LN essential oil (EO), ethanolic extract (EE) & hot/cold aqueous extract (AE). The EO exhibited strong antibacterial activity against all tested foodborne spoilage & pathogenic bacteria, whereas this activity was less pronounced or even nonexistent in the EE & AE.

   • According to Ozcan B (2010)

     Excerpt This study was carried out to determine the in vitro antimicrobial and antioxidant activities of the essential oil, seed oil, & methanolic extract of seed oil obtained from Laurus nobilis L. The methanolic extract of seed oil exhibited more effective antibacterial activity comparing to essential oil & seed oil, GC-MS analyses of the essential oil resulted in the identification of 25 compounds.

   • According to Cherrat L (2014)

     Excerpt This study describes the antioxidant & antimicrobial activity of Laurus nobilis L. Results: EOs obtained by steam distillation from aerial parts of L nobilis & M communis were analysed by using gas chromatography-mass spectrometry.

   • According to El Malti J (2009)

     Excerpt El Malti J et al, ANTIBACTERIAL EFFECT, HISTOLOGICAL IMPACT & OXIDATIVE STRESS STUDIES FROM LAURUS NOBILIS EXTRACT, Jl of Food Quality, 32(2), 2009,.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.