Lepidium sativum (Watercress) : medicinal properties in alcoholic extraction

Lepidium sativum (Watercress, Kréson, Cresson) — family Brassicacées.

Scientific synonyms : Rabis chinensis-R ex W, Cardamon sativum-(L)-F, Lepidium spinencens-(DC)-J, Nasturnium sativum-(L)M, Thlaspidium sativum-(L)-S..

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 8 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 70 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Cancer: adjuvant treatment for liver cancer and leukaemia

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Nazir S (2021)

     Excerpt Hepatocellular carcinoma (HCC) is the most common primary liver cancer & the greatest cause of cancer-related death in the world. In this study, in vitro cytotoxic efficiency evaluation of LS fractions was performed against two hepatocellular carcinoma cell lines (HuH-7 & HEPG-2), & the expression of some apoptotic genes was explored.

   • According to Painuli S (2022)

     Excerpt Preclinical studies (in vitro & in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, & fracture/bone healing activities of LS & support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. The roots, leaves, & seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds.

   • According to Ahmed TE (2022)

     Excerpt The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFL Don male mice. Then on day 29, the mice were fasted overnight, anaesthetized & sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation.

   • According to Abdul-Malek HA (2021)

     Excerpt Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Aim of the study: In this study, we investigated the beneficial effect of LS ethanol & aqueous seed extracts on obesity, oxidative, inflammatory, & insulin sensitivity changes in the liver tissue of high fat diet (HFD)-fed rats.

   • According to Ibrahim IA (n.d.)

     Excerpt Non-alcoholic fatty liver disease (NAFLD) occurs by excrescent hepatic fat accumulation without the excessive intake of dietary alcohol & can progress to non-alcoholic steatohepatitis (NASH) & cirrhosis. The data concludes that, daily administration of EEGS 400mg/kg b.w for six weeks is safe & possess hepatoprotective, antioxidant, hypolipidemic, anti-obesity, anti-angiogenic, & anti- steatosis characteristics in HFD-induced NAFLD.

2. 2

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Kamani M (2017)

     Excerpt Current study evaluated the possible protective efficiency of Lepidium sativum seed extract on fasting blood sugar (FBS) & then assessed histopathological change of epididymis in streptozotocin (STZ)-induced diabetic rats. Group 3 were diabetic rats receiving insulin in dose 3U/100 g body weight & Groups 4 & 5 were diabetic rats that received 0.1 cc of 200 & 400 mg/kg‚ ethanol extract of LS seed by gavages daily.

   • According to Abdul-Malek HA (2021)

     Excerpt Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Obesity-induced insulin resistance & chronic inflammation appears to be the most frequent cause of diabetes & its related metabolic complications; in this way new therapeutic approaches are needed to prevent the chronic obesity & insulin resistance.

   • According to Painuli S (2022)

     Excerpt Preclinical studies (in vitro & in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, & fracture/bone healing activities of LS & support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. The roots, leaves, & seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds.

   • According to Shukla P (2012)

     Excerpt sativum alkaloid have potential antidiabetic effect against alloxan-induced diabetes may be through reducing oxidative damage and modulating antioxidant enzymes. Antidiabetic profile of LSTA (50, 150 & 250 mg kg-1, i.p.) was assessed on alloxan induced diabetic rats upon 21 days continuous treatment.

   • According to Al-Snafi AE (2019)

     Excerpt Lepidium sativum contained many bioactive constituents included cardiac glycoside, alkaloids, phenolic, flavonoids, cardiotonic glycosides, coumarins, glucosinolates, carbohydrates, proteins and amino-acids, mucilage, resins, saponins, sterols, tannins, volatile oils, triterpene, sinapic acid & uric acid. The pharmacological investigation revealed that LS possessed antimicrobial, antidiabetic, antioxidant, anticancer, reproductive, gastrointestinal, respiratory, anti-inflammatory, analgesic, antipyretic, cardiovascular, hypolipidemic, diuretic, central nervous, fracture healing & protective effects.

3. 3

   Liver disorders: fatty liver, cirrhosis, hepatitis

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Raish M (2016)

     Excerpt Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/ lipopolysaccharide (400 mg/kg & 30 μg/kg) liver damage model in rats. Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis & high mortality there is urgent need for the development of safe & non-toxic hepatoprotective agents for the adequate management of hepatitis.

   • According to Ahmed TE (2022)

     Excerpt The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFL Don male mice. Then on day 29, the mice were fasted overnight, anaesthetized & sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation.

   • According to Abdul-Malek HA (2021)

     Excerpt Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Aim of the study: In this study, we investigated the beneficial effect of LS ethanol & aqueous seed extracts on obesity, oxidative, inflammatory, & insulin sensitivity changes in the liver tissue of high fat diet (HFD)-fed rats.

   • According to Ibrahim IA (n.d.)

     Excerpt Non-alcoholic fatty liver disease (NAFLD) occurs by excrescent hepatic fat accumulation without the excessive intake of dietary alcohol & can progress to non-alcoholic steatohepatitis (NASH) & cirrhosis. The data concludes that, daily administration of EEGS 400mg/kg b.w for six weeks is safe & possess hepatoprotective, antioxidant, hypolipidemic, anti-obesity, anti-angiogenic, & anti- steatosis characteristics in HFD-induced NAFLD.

   • According to Bafeel SO (2009)

     Excerpt Lepidium sativum is an annual plant grown in many regions of Saudi Arabia. Liver parenchyma in the form of vascular dilation & congestion of central & portal veins were observed in low doses (2 & 4 mg mL-1) given for 3 weeks, High doses given for 3 weeks showed peri-portal fibrosis & peri-vascular edema.

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.