Lepidium sativum (Kréson) : vertus médicinales en extraction alcoolique

Lepidium sativum (Kréson, Cresson, Watercress) — famille Brassicacées.

Synonymes scientifiques : Rabis chinensis-R ex W, Cardamon sativum-(L)-F, Lepidium spinencens-(DC)-J, Nasturnium sativum-(L)M, Thlaspidium sativum-(L)-S..

Cette base documente les extractions alcooliques (éthanol) des substances actives. Notre monographie recense actuellement 8 indications en extraction alcoolique pour cette espèce. Le catalogue Lapo v2 enregistre 70 références scientifiques pour cette espèce (détail intégral dans l’application).

Important — références scientifiques sur cette page publique : seuls de courts extraits de chaque source citée sont présentés (phrases d’abstract sélectionnées), conservés dans leur langue d’origine (le plus souvent l’anglais), sans traduction. Ces extraits ne constituent pas le texte intégral de l’article ni une bibliographie complète. Les fiches de référence complètes et le détail monographique sont disponibles dans l’application Lapo v2 (essai gratuit 30 jours).

1. 1

   Cancer : traitement adjuvant du carcinome hépatique & de la leucémie

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Nazir S (2021)

     Extrait Hepatocellular carcinoma (HCC) is the most common primary liver cancer & the greatest cause of cancer-related death in the world. In this study, in vitro cytotoxic efficiency evaluation of LS fractions was performed against two hepatocellular carcinoma cell lines (HuH-7 & HEPG-2), & the expression of some apoptotic genes was explored.

   • Selon Painuli S (2022)

     Extrait Preclinical studies (in vitro & in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, & fracture/bone healing activities of LS & support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. The roots, leaves, & seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds.

   • Selon Ahmed TE (2022)

     Extrait The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFL Don male mice. Then on day 29, the mice were fasted overnight, anaesthetized & sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation.

   • Selon Abdul-Malek HA (2021)

     Extrait Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Aim of the study: In this study, we investigated the beneficial effect of LS ethanol & aqueous seed extracts on obesity, oxidative, inflammatory, & insulin sensitivity changes in the liver tissue of high fat diet (HFD)-fed rats.

   • Selon Ibrahim IA (s.d.)

     Extrait Non-alcoholic fatty liver disease (NAFLD) occurs by excrescent hepatic fat accumulation without the excessive intake of dietary alcohol & can progress to non-alcoholic steatohepatitis (NASH) & cirrhosis. The data concludes that, daily administration of EEGS 400mg/kg b.w for six weeks is safe & possess hepatoprotective, antioxidant, hypolipidemic, anti-obesity, anti-angiogenic, & anti- steatosis characteristics in HFD-induced NAFLD.

2. 2

   Diabète mellitus de type II

   Partie usitée : Semence. Profil pharmacologique documenté : Insuline-like.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Kamani M (2017)

     Extrait Current study evaluated the possible protective efficiency of Lepidium sativum seed extract on fasting blood sugar (FBS) & then assessed histopathological change of epididymis in streptozotocin (STZ)-induced diabetic rats. Group 3 were diabetic rats receiving insulin in dose 3U/100 g body weight & Groups 4 & 5 were diabetic rats that received 0.1 cc of 200 & 400 mg/kg‚ ethanol extract of LS seed by gavages daily.

   • Selon Abdul-Malek HA (2021)

     Extrait Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Obesity-induced insulin resistance & chronic inflammation appears to be the most frequent cause of diabetes & its related metabolic complications; in this way new therapeutic approaches are needed to prevent the chronic obesity & insulin resistance.

   • Selon Painuli S (2022)

     Extrait Preclinical studies (in vitro & in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, & fracture/bone healing activities of LS & support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. The roots, leaves, & seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds.

   • Selon Shukla P (2012)

     Extrait sativum alkaloid have potential antidiabetic effect against alloxan-induced diabetes may be through reducing oxidative damage and modulating antioxidant enzymes. Antidiabetic profile of LSTA (50, 150 & 250 mg kg-1, i.p.) was assessed on alloxan induced diabetic rats upon 21 days continuous treatment.

   • Selon Al-Snafi AE (2019)

     Extrait Lepidium sativum contained many bioactive constituents included cardiac glycoside, alkaloids, phenolic, flavonoids, cardiotonic glycosides, coumarins, glucosinolates, carbohydrates, proteins and amino-acids, mucilage, resins, saponins, sterols, tannins, volatile oils, triterpene, sinapic acid & uric acid. The pharmacological investigation revealed that LS possessed antimicrobial, antidiabetic, antioxidant, anticancer, reproductive, gastrointestinal, respiratory, anti-inflammatory, analgesic, antipyretic, cardiovascular, hypolipidemic, diuretic, central nervous, fracture healing & protective effects.

3. 3

   Troubles hépatiques : stéatose hépatique, cirrhose, hépatite

   Partie usitée : Semence.

   Références scientifiques (courts extraits)

   Courts extraits uniquement (pas le texte intégral de l’article). Fiches de référence complètes dans l’application Lapo v2.

   • Selon Raish M (2016)

     Extrait Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/ lipopolysaccharide (400 mg/kg & 30 μg/kg) liver damage model in rats. Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis & high mortality there is urgent need for the development of safe & non-toxic hepatoprotective agents for the adequate management of hepatitis.

   • Selon Ahmed TE (2022)

     Extrait The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFL Don male mice. Then on day 29, the mice were fasted overnight, anaesthetized & sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation.

   • Selon Abdul-Malek HA (2021)

     Extrait Lepidium sativum has been extensively used in traditional alternative medicine for cough, skin disease, liver disorder, diuretic, gastrointestinal problems, hair loss treatment, milk secretion during lactation as well as antioxidant, antihypertensive, anti-inflammatory, & antidiabetic activities. Aim of the study: In this study, we investigated the beneficial effect of LS ethanol & aqueous seed extracts on obesity, oxidative, inflammatory, & insulin sensitivity changes in the liver tissue of high fat diet (HFD)-fed rats.

   • Selon Ibrahim IA (s.d.)

     Extrait Non-alcoholic fatty liver disease (NAFLD) occurs by excrescent hepatic fat accumulation without the excessive intake of dietary alcohol & can progress to non-alcoholic steatohepatitis (NASH) & cirrhosis. The data concludes that, daily administration of EEGS 400mg/kg b.w for six weeks is safe & possess hepatoprotective, antioxidant, hypolipidemic, anti-obesity, anti-angiogenic, & anti- steatosis characteristics in HFD-induced NAFLD.

   • Selon Bafeel SO (2009)

     Extrait Lepidium sativum is an annual plant grown in many regions of Saudi Arabia. Liver parenchyma in the form of vascular dilation & congestion of central & portal veins were observed in low doses (2 & 4 mg mL-1) given for 3 weeks, High doses given for 3 weeks showed peri-portal fibrosis & peri-vascular edema.

D’autres indications (y compris d’autres modes d’extraction le cas échéant), posologies, précautions d’emploi et les <strong>références scientifiques complètes</strong> (fiches intégrales, pas seulement les courts extraits ci-dessus) sont disponibles dans la fiche monographique de l’application Lapo v2.