Leucaena leucocephala (Tamaren-makak) : medicinal properties in alcoholic extraction

Leucaena leucocephala (Tamaren-makak, Tamaren-bata, Makata-bous, Monval, Zakadi, Macaque-tamarin, Bastard tamarin, Pouch macata, Tamarin-à-macaque, Tamarin-batârd, Macata-à-bourse) — family Mimosacées.

Scientific synonyms : Acacia glauca-Willd, Mimosa. glauca-L, M. leucocephala-Lam, M. Leucocephala leuco-(Wiss)-Benth.

This database documents alcoholic (ethanol) extractions of active substances. Our monograph currently lists 13 indications in alcoholic extraction for this species. The Lapo v2 catalogue records 133 scientific references for this species (full detail in the application).

Important — scientific references on this public page: only a short excerpt of each cited source is shown (selected abstract sentences), kept in the original language of the publication (most often English), without translation. These excerpts are not the full article text and are not a complete bibliography. The full reference records and complete monographic detail are available in the Lapo v2 application (free 30-day trial).

1. 1

   Type II diabetes mellitus

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chowtivannakul P (2016)

     Excerpt Leucaena leucocephala (Lam.) de Wit has been used for various purposes such as treatment of stomach diseases, facilitation of abortion, contraception and the treatment of diabetes. Antidiabetic activity testing was carried out by giving LLSE at an oral dose of 250 mg/kg body weight to streptozotocin-induced diabetic rats daily for 6 wk.

   • According to Xu Y (2018)

     Excerpt We investigated the constituents of Leucaena leucocephala foliage collected from Guangdong province in China & isolated 17 diverse flavonoids (1–17), including flavones (5–9, 11, & 12), flavonols (1, 10, & 16), flavanone 4, flavanonol 15, & flavonol glycosides (2, 3, 13, 14, & 17). pHRE-Luc inductive activity to mimic the activation of erythropoietin (EPO) gene, anti-inflammatory, antidiabetic, & antioxidant activities of isolated flavonoids (1–17) were evaluated.

   • According to Talubmook C (2013)

     Excerpt Talubmook C et al, Hypoglycemic & Hypolipidemic Properties of Leaf Extracts from Phyllanthus acidus (L.) Skeels., Leucaena leucocephala (Lam.) de Wit & Psidium guajava (L.) in Streptozotocin-Induced Diabetic Rats, Int of Bio-Sciences, 25(2) :2013-Abstract— Star gooseberry Phyllanthus acidus (L.) Skeels, lead tree Leucaena leucocephala (Lam.) de Wit & guava Psidium guajava (L.) are commonly well known plants & have been widely used in folk medicine for the treatment of many diseases in Thailand. The results revealed, that the extracts significantly (p<0.05) decreased blood glucose level, total cholesterol (TC), triglyceride, (TG), low density lipoprotein (LDL), blood urea nitrogen (BUN) & creatinine but increased high density lipoprotein (HDL) & serum insulin in the diabetic treated rats.

   • According to Sarma P (2024)

     Excerpt Leucaena leucocephala. (Lam.) de Wit, a traditional medicinal plant, has been reported among the ethnic communities of Mexico, Indonesia, China, & India for the treatment of diabetes, obesity, & related complications.

   • According to Chowtivannakul S (2012)

     Excerpt Chowtivannakul S et al, Antioxidant & antidiabetic activities of leaf & seed extracts from Leucaena leucocephala (Lam.) de Wit.

2. 2

   Cancer: chemoprevention (antimutagenic action)

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Chatchanayuenyong R (2020)

     Excerpt Several medicinal plants have recently increased in the involvement of chemotherapeutic drugs development, including Leucaena leucocephala & Dolichandrone serrulata. serrulata ethanolic extracts (125–500 μg/ml) have been proposed in this study of possessing antioxidant & anti-migration activity, as well as the ability in induce cancer cell death.

   • According to RATIKORN C (2013)

     Excerpt Leucaena leucocephala has been reported of possessing antioxidant, antidiabetic & anticholinesterase activity; as well as the toxic substance called mimosine. leucocephala in endothelium functions & has been found to have an appropriate concentration at 0.05 mg/mL in reducing oxidative stress condition in impaired fasting blood glucose patients.

   • According to Chung HH (2017)

     Excerpt These data indicate that LL could be a potent therapeutic agent for the prevention & treatment of oral cancer & a prominent plant source for anticancer research in the future. leucocephala extract on SCC-9 & SAS oral cancer cells & examined the potential inhibitory mechanisms involved.

   • According to She LC (2017)

     Excerpt The objective of this study was to evaluate the anti-cancer effects of compounds obtained from the plant Leucaena leucocephala in human chronic myelogenous leukaemia, prostate, liver, tongue, lung, melanoma, gastric & colon adenocarcinoma cancer cell lines. These results indicated that investigation on the anti-proliferation, anti-migration & anti-invasion effects of components from L leucocephala,.

   • According to Inglum P (2011)

     Excerpt A new lectin, leucocephalin was evaluated in the seed extracts of the four strains of Leucaena leucocephala. The extract of KU 26 strain was found to have the highest lectin specific activity with strong antimutagenic potency.

3. 3

   Diarrhoea

   Plant part used: Seed.

   Scientific references (short excerpts)

   Short excerpts only (not the full article). Full reference records are in the Lapo v2 application.

   • According to Hussein S (2020)

     Excerpt This study was investigating the antidiarrheal activity of the ethanol extracts of Leucaena leucocephala (Lam) de Wit seeds induced by oleum ricini & intestinal transit methods for rats. leucocephala seed extract at doses of 100, 200, & 400 mg/kg bw has been shown to significantly delay the onset of diarrhea, reduce diarrhea frequency, stool weight & duration of diarrhea compared with Na CMC as a negative control (p < 0.05).

Further indications (including other extraction modes where applicable), dosages, precautions for use, and the <strong>full scientific references</strong> (complete records, not only the short excerpts above) are available in the complete monographic record in the Lapo v2 application.